354 research outputs found

    Current issues of the management of socio-economic systems in terms of globalization challenges

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    The authors of the scientific monograph have come to the conclusion that the management of socio-economic systems in the terms of global challenges requires the use of mechanisms to ensure security, optimise the use of resource potential, increase competitiveness, and provide state support to economic entities. Basic research focuses on assessment of economic entities in the terms of global challenges, analysis of the financial system, migration flows, logistics and product exports, territorial development. The research results have been implemented in the different decision-making models in the context of global challenges, strategic planning, financial and food security, education management, information technology and innovation. The results of the study can be used in the developing of directions, programmes and strategies for sustainable development of economic entities and regions, increasing the competitiveness of products and services, decision-making at the level of ministries and agencies that regulate the processes of managing socio-economic systems. The results can also be used by students and young scientists in the educational process and conducting scientific research on the management of socio-economic systems in the terms of global challenges

    The study of renal function and toxicity using zebrafish (Danio rerio) larvae as a vertebrate model

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    Zebrafish (Danio rerio) is a powerful model in biomedical and pharmaceutical sciences. The zebrafish model was introduced to toxicological sciences in 1960, followed by its use in biomedical sciences to investigate vertebrate gene functions. As a consequence of many research projects in this field, the study of human genetic diseases became instantly feasible. Consequently, zebrafish have been intensively used in developmental biology and associated disciplines. Due to the simple administration of medicines and the high number of offspring, zebrafish larvae became widely more popular in pharmacological studies in the following years. In the past decade, zebrafish larvae were further established as a vertebrate model in the field of pharmacokinetics and nanomedicines. In this PhD thesis, zebrafish larvae were investigated as an earlystage in vivo vertebrate model to study renal function, toxicity, and were applied in drug-targeting projects using nanomedicines. The first part focused on the characterization of the renal function of three-to four-dayold zebrafish larvae. Non-renal elimination processes were additionally described. Moreover, injection techniques, imaging parameters, and post-image processing scripts were established to serve as a toolbox for follow-up projects. The second part analyzed the impact of gentamicin (a nephrotoxin) on the morphology of the pronephros of zebrafish larvae. Imaging methodologies such as fluorescent-based laser scanning microscopy and X-ray-based microtomography were applied. A profound comparison study of specimens acquired with different laboratory X-ray-based microtomography devices and a radiation facility was done to promote the use of X-ray-based microtomography for broader biomedical applications. In the third part, the toxicity of nephrotoxins on mitochondria in renal epithelial cells of proximal tubules was assessed using the zebrafish larva model. Findings were compared with other teleost models such as isolated renal tubules of killifish (Fundulus heteroclitus). In view of the usefulness and high predictability of the zebrafish model, it was applied to study the pharmacokinetics of novel nanoparticles in the fourth part. Various in vivo pharmacokinetic parameters such as drug release, transfection of mRNA/pDNA plasmids, macrophage clearance, and the characterization of novel drug carriers that were manipulated with ultrasound were assessed in multiple collaborative projects. Altogether, the presented zebrafish model showed to be a reliable in vivo vertebrate model to assess renal function, toxicity, and pharmacokinetics of nanoparticles. The application of the presented model will hopefully encourage others to reduce animal experiments in preliminary studies by fostering the use of zebrafish larvae

    SoC-based FPGA architecture for image analysis and other highly demanding applications

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    Al giorno d'oggi, lo sviluppo di algoritmi si concentra su calcoli efficienti in termini di prestazioni ed efficienza energetica. Tecnologie come il field programmable gate array (FPGA) e il system on chip (SoC) basato su FPGA (FPGA/SoC) hanno dimostrato la loro capacità di accelerare applicazioni di calcolo intensive risparmiando al contempo il consumo energetico, grazie alla loro capacità di elevato parallelismo e riconfigurazione dell'architettura. Attualmente, i cicli di progettazione esistenti per FPGA/SoC sono lunghi, a causa della complessità dell'architettura. Pertanto, per colmare il divario tra le applicazioni e le architetture FPGA/SoC e ottenere un design hardware efficiente per l'analisi delle immagini e altri applicazioni altamente demandanti utilizzando lo strumento di sintesi di alto livello, vengono prese in considerazione due strategie complementari: tecniche ad hoc e stima delle prestazioni. Per quanto riguarda le tecniche ad-hoc, tre applicazioni molto impegnative sono state accelerate attraverso gli strumenti HLS: discriminatore di forme di impulso per i raggi cosmici, classificazione automatica degli insetti e re-ranking per il recupero delle informazioni, sottolineando i vantaggi quando questo tipo di applicazioni viene attraversato da tecniche di compressione durante il targeting dispositivi FPGA/SoC. Inoltre, in questa tesi viene proposto uno stimatore delle prestazioni per l'accelerazione hardware per prevedere efficacemente l'utilizzo delle risorse e la latenza per FPGA/SoC, costruendo un ponte tra l'applicazione e i domini architetturali. Lo strumento integra modelli analitici per la previsione delle prestazioni e un motore design space explorer (DSE) per fornire approfondimenti di alto livello agli sviluppatori di hardware, composto da due motori indipendenti: DSE basato sull'ottimizzazione a singolo obiettivo e DSE basato sull'ottimizzazione evolutiva multiobiettivo.Nowadays, the development of algorithms focuses on performance-efficient and energy-efficient computations. Technologies such as field programmable gate array (FPGA) and system on chip (SoC) based on FPGA (FPGA/SoC) have shown their ability to accelerate intensive computing applications while saving power consumption, owing to their capability of high parallelism and reconfiguration of the architecture. Currently, the existing design cycles for FPGA/SoC are time-consuming, owing to the complexity of the architecture. Therefore, to address the gap between applications and FPGA/SoC architectures and to obtain an efficient hardware design for image analysis and highly demanding applications using the high-level synthesis tool, two complementary strategies are considered: ad-hoc techniques and performance estimator. Regarding ad-hoc techniques, three highly demanding applications were accelerated through HLS tools: pulse shape discriminator for cosmic rays, automatic pest classification, and re-ranking for information retrieval, emphasizing the benefits when this type of applications are traversed by compression techniques when targeting FPGA/SoC devices. Furthermore, a comprehensive performance estimator for hardware acceleration is proposed in this thesis to effectively predict the resource utilization and latency for FPGA/SoC, building a bridge between the application and architectural domains. The tool integrates analytical models for performance prediction, and a design space explorer (DSE) engine for providing high-level insights to hardware developers, composed of two independent sub-engines: DSE based on single-objective optimization and DSE based on evolutionary multi-objective optimization

    Artificial Intelligence-based Cybersecurity for Connected and Automated Vehicles

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    The damaging effects of cyberattacks to an industry like the Cooperative Connected and Automated Mobility (CCAM) can be tremendous. From the least important to the worst ones, one can mention for example the damage in the reputation of vehicle manufacturers, the increased denial of customers to adopt CCAM, the loss of working hours (having direct impact on the European GDP), material damages, increased environmental pollution due e.g., to traffic jams or malicious modifications in sensors’ firmware, and ultimately, the great danger for human lives, either they are drivers, passengers or pedestrians. Connected vehicles will soon become a reality on our roads, bringing along new services and capabilities, but also technical challenges and security threats. To overcome these risks, the CARAMEL project has developed several anti-hacking solutions for the new generation of vehicles. CARAMEL (Artificial Intelligence-based Cybersecurity for Connected and Automated Vehicles), a research project co-funded by the European Union under the Horizon 2020 framework programme, is a project consortium with 15 organizations from 8 European countries together with 3 Korean partners. The project applies a proactive approach based on Artificial Intelligence and Machine Learning techniques to detect and prevent potential cybersecurity threats to autonomous and connected vehicles. This approach has been addressed based on four fundamental pillars, namely: Autonomous Mobility, Connected Mobility, Electromobility, and Remote Control Vehicle. This book presents theory and results from each of these technical directions

    Financialisation, regulation and the “social and moral mission” of English housing associations

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    In recent years English housing associations have faced criticism on two principal fronts. Firstly, for placing greater emphasis on commercial development as opposed to social rented housing. Secondly, for numerous cases of disrepair, damp and mould. This thesis explores the role of financialisation in explaining the purported mission creep of housing associations, with sectoral governance transformed by the increased importance of financial actors, markets and practices post-2010. The thesis adopts a mixed-methods approach, combining longitudinal clustering of balance sheet data, analysis of a natural experiment, qualitative document analysis, and semi-structured interviews. The findings suggest that several forms of financialisation exist across the sector, but organisations share a common strategic principle of accessing capital by leveraging housing and land as an asset. This asset strategy has been a key driver of commercial activity and declining social rented supply among some associations. Moreover, a regulatory framework that prioritised financial viability over consumer standards has underpinned the increased importance of private finance. These findings challenge the notion that financialisation is consigned to large landlords, or is in retreat. Rather, financialisation is variegated and dynamic. The period of low-interest rates and low landlord expenditure that characterised the early 2010s has given way to a period of constrained borrowing capacity and significant investment in existing homes. Difficulties in accessing sufficient private and public funding are contributing to delays in remediating building safety issues and decarbonising social housing, as well as placing some associations at risk of financial collapse. Furthermore, the restrictions placed upon some landlords by their loan covenants are one of the contributing factors to disrepair. Nonetheless, housing associations are responsive to changes in their funding environment, and recent increases in government capital grant in areas of ‘high affordability pressure’ have led to a nascent increase in new social rent supply

    Modelling, Monitoring, Control and Optimization for Complex Industrial Processes

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    This reprint includes 22 research papers and an editorial, collected from the Special Issue "Modelling, Monitoring, Control and Optimization for Complex Industrial Processes", highlighting recent research advances and emerging research directions in complex industrial processes. This reprint aims to promote the research field and benefit the readers from both academic communities and industrial sectors

    Enabling Scalability: Graph Hierarchies and Fault Tolerance

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    In this dissertation, we explore approaches to two techniques for building scalable algorithms. First, we look at different graph problems. We show how to exploit the input graph\u27s inherent hierarchy for scalable graph algorithms. The second technique takes a step back from concrete algorithmic problems. Here, we consider the case of node failures in large distributed systems and present techniques to quickly recover from these. In the first part of the dissertation, we investigate how hierarchies in graphs can be used to scale algorithms to large inputs. We develop algorithms for three graph problems based on two approaches to build hierarchies. The first approach reduces instance sizes for NP-hard problems by applying so-called reduction rules. These rules can be applied in polynomial time. They either find parts of the input that can be solved in polynomial time, or they identify structures that can be contracted (reduced) into smaller structures without loss of information for the specific problem. After solving the reduced instance using an exponential-time algorithm, these previously contracted structures can be uncontracted to obtain an exact solution for the original input. In addition to a simple preprocessing procedure, reduction rules can also be used in branch-and-reduce algorithms where they are successively applied after each branching step to build a hierarchy of problem kernels of increasing computational hardness. We develop reduction-based algorithms for the classical NP-hard problems Maximum Independent Set and Maximum Cut. The second approach is used for route planning in road networks where we build a hierarchy of road segments based on their importance for long distance shortest paths. By only considering important road segments when we are far away from the source and destination, we can substantially speed up shortest path queries. In the second part of this dissertation, we take a step back from concrete graph problems and look at more general problems in high performance computing (HPC). Here, due to the ever increasing size and complexity of HPC clusters, we expect hardware and software failures to become more common in massively parallel computations. We present two techniques for applications to recover from failures and resume computation. Both techniques are based on in-memory storage of redundant information and a data distribution that enables fast recovery. The first technique can be used for general purpose distributed processing frameworks: We identify data that is redundantly available on multiple machines and only introduce additional work for the remaining data that is only available on one machine. The second technique is a checkpointing library engineered for fast recovery using a data distribution method that achieves balanced communication loads. Both our techniques have in common that they work in settings where computation after a failure is continued with less machines than before. This is in contrast to many previous approaches that---in particular for checkpointing---focus on systems that keep spare resources available to replace failed machines. Overall, we present different techniques that enable scalable algorithms. While some of these techniques are specific to graph problems, we also present tools for fault tolerant algorithms and applications in a distributed setting. To show that those can be helpful in many different domains, we evaluate them for graph problems and other applications like phylogenetic tree inference

    A review of commercialisation mechanisms for carbon dioxide removal

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    The deployment of carbon dioxide removal (CDR) needs to be scaled up to achieve net zero emission pledges. In this paper we survey the policy mechanisms currently in place globally to incentivise CDR, together with an estimate of what different mechanisms are paying per tonne of CDR, and how those costs are currently distributed. Incentive structures are grouped into three structures, market-based, public procurement, and fiscal mechanisms. We find the majority of mechanisms currently in operation are underresourced and pay too little to enable a portfolio of CDR that could support achievement of net zero. The majority of mechanisms are concentrated in market-based and fiscal structures, specifically carbon markets and subsidies. While not primarily motivated by CDR, mechanisms tend to support established afforestation and soil carbon sequestration methods. Mechanisms for geological CDR remain largely underdeveloped relative to the requirements of modelled net zero scenarios. Commercialisation pathways for CDR require suitable policies and markets throughout the projects development cycle. Discussion and investment in CDR has tended to focus on technology development. Our findings suggest that an equal or greater emphasis on policy innovation may be required if future requirements for CDR are to be met. This study can further support research and policy on the identification of incentive gaps and realistic potential for CDR globally

    5th International Conference on Advanced Research Methods and Analytics (CARMA 2023)

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    Research methods in economics and social sciences are evolving with the increasing availability of Internet and Big Data sources of information. As these sources, methods, and applications become more interdisciplinary, the 5th International Conference on Advanced Research Methods and Analytics (CARMA) is a forum for researchers and practitioners to exchange ideas and advances on how emerging research methods and sources are applied to different fields of social sciences as well as to discuss current and future challenges.Martínez Torres, MDR.; Toral Marín, S. (2023). 5th International Conference on Advanced Research Methods and Analytics (CARMA 2023). Editorial Universitat Politècnica de València. https://doi.org/10.4995/CARMA2023.2023.1700
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