50,636 research outputs found

    Secure, reliable and dynamic access to distributed clinical data

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    An abundance of statistical and scientific data exists in the area of clinical and epidemiological studies. Much of this data is distributed across regional, national and international boundaries with different policies on access and usage, and a multitude of different schemata for the data often complicated by the variety of supporting clinical coding schemes. This prevents the wide scale collation and analysis of such data as is often needed to infer clinical outcomes and to determine the often moderate effect of drugs. Through grid technologies it is possible to overcome the barriers introduced by distribution of heterogeneous data and services. However reliability, dynamicity and fine-grained security are essential in this domain, and are not typically offered by current grids. The MRC funded VOTES project (Virtual Organisations for Trials and Epidemiological Studies) has implemented a prototype infrastructure specifically designed to meet these challenges. This paper describes this on-going implementation effort and the lessons learned in building grid frameworks for and within a clinical environment

    Grid infrastructures supporting paediatric endocrinology across Europe

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    Paediatric endocrinology is a highly specialised area of clinical medicine with many experts with specific knowledge distributed over a wide geographical area. The European Society for Paediatric Endocrinology (ESPE) is an example of such a body of experts that require regular collaboration and sharing of data and knowledge. This paper describes work, developed as a corollary to the VOTES project [1] and implementing similar architectures, to provide a data grid that allows information to be efficiently distributed between collaborating partners, and also allows wide-scale analyses to be run over the entire data-set, which necessarily involves crossing domain boundaries and negotiating data access between administrations that only trust each other to a limited degree

    Integrated Border Management at the EU Level. CEPS Working Documents No. 227, 1 August 2005

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    In times marked by trends as diverse as economic globalisation, international migration as well as fear of terrorism and organised crime, the efficient handling of borders has become an issue of political priority, in the EU and across the world. Modern, economy-oriented states have to rely on a flourishing trade and offer a comfortable degree of security to their citizens. The formula commonly chosen in combining these two objectives is that of ‘integrated border management’, which represents the delicate attempt to marry security concerns with trade facilitation. If the implementation of this innovative approach is already proving to be a challenge to well-established nation states, it becomes a genuine balancing act for an incomplete federation such as the EU, with its sensitive mix of a single external border and 25 separate legal/administrative systems. This working paper seeks to illustrate the difficulties encountered by the EU and develop solutions that should firmly go into the direction of a coherent, communitarian approach in border management, such as that sketched out by the recent Council Regulation No. 2007/2004 establishing the European Border Agency known as FRONTEX

    A Taxonomy of Data Grids for Distributed Data Sharing, Management and Processing

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    Data Grids have been adopted as the platform for scientific communities that need to share, access, transport, process and manage large data collections distributed worldwide. They combine high-end computing technologies with high-performance networking and wide-area storage management techniques. In this paper, we discuss the key concepts behind Data Grids and compare them with other data sharing and distribution paradigms such as content delivery networks, peer-to-peer networks and distributed databases. We then provide comprehensive taxonomies that cover various aspects of architecture, data transportation, data replication and resource allocation and scheduling. Finally, we map the proposed taxonomy to various Data Grid systems not only to validate the taxonomy but also to identify areas for future exploration. Through this taxonomy, we aim to categorise existing systems to better understand their goals and their methodology. This would help evaluate their applicability for solving similar problems. This taxonomy also provides a "gap analysis" of this area through which researchers can potentially identify new issues for investigation. Finally, we hope that the proposed taxonomy and mapping also helps to provide an easy way for new practitioners to understand this complex area of research.Comment: 46 pages, 16 figures, Technical Repor
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