Entropy in Image Analysis II

Image analysis is a fundamental task for any application where extracting information from images is required. The analysis requires highly sophisticated numerical and analytical methods, particularly for those applications in medicine, security, and other fields where the results of the processing consist of data of vital importance. This fact is evident from all the articles composing the Special Issue "Entropy in Image Analysis II", in which the authors used widely tested methods to verify their results. In the process of reading the present volume, the reader will appreciate the richness of their methods and applications, in particular for medical imaging and image security, and a remarkable cross-fertilization among the proposed research areas

Recent Advances in Signal Processing

The signal processing task is a very critical issue in the majority of new technological inventions and challenges in a variety of applications in both science and engineering fields. Classical signal processing techniques have largely worked with mathematical models that are linear, local, stationary, and Gaussian. They have always favored closed-form tractability over real-world accuracy. These constraints were imposed by the lack of powerful computing tools. During the last few decades, signal processing theories, developments, and applications have matured rapidly and now include tools from many areas of mathematics, computer science, physics, and engineering. This book is targeted primarily toward both students and researchers who want to be exposed to a wide variety of signal processing techniques and algorithms. It includes 27 chapters that can be categorized into five different areas depending on the application at hand. These five categories are ordered to address image processing, speech processing, communication systems, time-series analysis, and educational packages respectively. The book has the advantage of providing a collection of applications that are completely independent and self-contained; thus, the interested reader can choose any chapter and skip to another without losing continuity

Data Hiding and Its Applications

Data hiding techniques have been widely used to provide copyright protection, data integrity, covert communication, non-repudiation, and authentication, among other applications. In the context of the increased dissemination and distribution of multimedia content over the internet, data hiding methods, such as digital watermarking and steganography, are becoming increasingly relevant in providing multimedia security. The goal of this book is to focus on the improvement of data hiding algorithms and their different applications (both traditional and emerging), bringing together researchers and practitioners from different research fields, including data hiding, signal processing, cryptography, and information theory, among others

Novel computational techniques for mapping and classifying Next-Generation Sequencing data

Since their emergence around 2006, Next-Generation Sequencing technologies have been revolutionizing biological and medical research. Quickly obtaining an extensive amount of short or long reads of DNA sequence from almost any biological sample enables detecting genomic variants, revealing the composition of species in a metagenome, deciphering cancer biology, decoding the evolution of living or extinct species, or understanding human migration patterns and human history in general. The pace at which the throughput of sequencing technologies is increasing surpasses the growth of storage and computer capacities, which creates new computational challenges in NGS data processing. In this thesis, we present novel computational techniques for read mapping and taxonomic classification. With more than a hundred of published mappers, read mapping might be considered fully solved. However, the vast majority of mappers follow the same paradigm and only little attention has been paid to non-standard mapping approaches. Here, we propound the so-called dynamic mapping that we show to significantly improve the resulting alignments compared to traditional mapping approaches. Dynamic mapping is based on exploiting the information from previously computed alignments, helping to improve the mapping of subsequent reads. We provide the first comprehensive overview of this method and demonstrate its qualities using Dynamic Mapping Simulator, a pipeline that compares various dynamic mapping scenarios to static mapping and iterative referencing. An important component of a dynamic mapper is an online consensus caller, i.e., a program collecting alignment statistics and guiding updates of the reference in the online fashion. We provide Ococo, the first online consensus caller that implements a smart statistics for individual genomic positions using compact bit counters. Beyond its application to dynamic mapping, Ococo can be employed as an online SNP caller in various analysis pipelines, enabling SNP calling from a stream without saving the alignments on disk. Metagenomic classification of NGS reads is another major topic studied in the thesis. Having a database with thousands of reference genomes placed on a taxonomic tree, the task is to rapidly assign a huge amount of NGS reads to tree nodes, and possibly estimate the relative abundance of involved species. In this thesis, we propose improved computational techniques for this task. In a series of experiments, we show that spaced seeds consistently improve the classification accuracy. We provide Seed-Kraken, a spaced seed extension of Kraken, the most popular classifier at present. Furthermore, we suggest ProPhyle, a new indexing strategy based on a BWT-index, obtaining a much smaller and more informative index compared to Kraken. We provide a modified version of BWA that improves the BWT-index for a quick k-mer look-up

The Fifth NASA Symposium on VLSI Design

The fifth annual NASA Symposium on VLSI Design had 13 sessions including Radiation Effects, Architectures, Mixed Signal, Design Techniques, Fault Testing, Synthesis, Signal Processing, and other Featured Presentations. The symposium provides insights into developments in VLSI and digital systems which can be used to increase data systems performance. The presentations share insights into next generation advances that will serve as a basis for future VLSI design

Application and Theory of Multimedia Signal Processing Using Machine Learning or Advanced Methods

This Special Issue is a book composed by collecting documents published through peer review on the research of various advanced technologies related to applications and theories of signal processing for multimedia systems using ML or advanced methods. Multimedia signals include image, video, audio, character recognition and optimization of communication channels for networks. The specific contents included in this book are data hiding, encryption, object detection, image classification, and character recognition. Academics and colleagues who are interested in these topics will find it interesting to read

Design of a secure architecture for the exchange of biomedical information in m-Health scenarios

El paradigma de m-Salud (salud móvil) aboga por la integración masiva de las más avanzadas tecnologías de comunicación, red móvil y sensores en aplicaciones y sistemas de salud, para fomentar el despliegue de un nuevo modelo de atención clínica centrada en el usuario/paciente. Este modelo tiene por objetivos el empoderamiento de los usuarios en la gestión de su propia salud (p.ej. aumentando sus conocimientos, promocionando estilos de vida saludable y previniendo enfermedades), la prestación de una mejor tele-asistencia sanitaria en el hogar para ancianos y pacientes crónicos y una notable disminución del gasto de los Sistemas de Salud gracias a la reducción del número y la duración de las hospitalizaciones. No obstante, estas ventajas, atribuidas a las aplicaciones de m-Salud, suelen venir acompañadas del requisito de un alto grado de disponibilidad de la información biomédica de sus usuarios para garantizar una alta calidad de servicio, p.ej. fusionar varias señales de un usuario para obtener un diagnóstico más preciso. La consecuencia negativa de cumplir esta demanda es el aumento directo de las superficies potencialmente vulnerables a ataques, lo que sitúa a la seguridad (y a la privacidad) del modelo de m-Salud como factor crítico para su éxito. Como requisito no funcional de las aplicaciones de m-Salud, la seguridad ha recibido menos atención que otros requisitos técnicos que eran más urgentes en etapas de desarrollo previas, tales como la robustez, la eficiencia, la interoperabilidad o la usabilidad. Otro factor importante que ha contribuido a retrasar la implementación de políticas de seguridad sólidas es que garantizar un determinado nivel de seguridad implica unos costes que pueden ser muy relevantes en varias dimensiones, en especial en la económica (p.ej. sobrecostes por la inclusión de hardware extra para la autenticación de usuarios), en el rendimiento (p.ej. reducción de la eficiencia y de la interoperabilidad debido a la integración de elementos de seguridad) y en la usabilidad (p.ej. configuración más complicada de dispositivos y aplicaciones de salud debido a las nuevas opciones de seguridad). Por tanto, las soluciones de seguridad que persigan satisfacer a todos los actores del contexto de m-Salud (usuarios, pacientes, personal médico, personal técnico, legisladores, fabricantes de dispositivos y equipos, etc.) deben ser robustas y al mismo tiempo minimizar sus costes asociados. Esta Tesis detalla una propuesta de seguridad, compuesta por cuatro grandes bloques interconectados, para dotar de seguridad a las arquitecturas de m-Salud con unos costes reducidos. El primer bloque define un esquema global que proporciona unos niveles de seguridad e interoperabilidad acordes con las características de las distintas aplicaciones de m-Salud. Este esquema está compuesto por tres capas diferenciadas, diseñadas a la medidas de los dominios de m-Salud y de sus restricciones, incluyendo medidas de seguridad adecuadas para la defensa contra las amenazas asociadas a sus aplicaciones de m-Salud. El segundo bloque establece la extensión de seguridad de aquellos protocolos estándar que permiten la adquisición, el intercambio y/o la administración de información biomédica -- por tanto, usados por muchas aplicaciones de m-Salud -- pero no reúnen los niveles de seguridad detallados en el esquema previo. Estas extensiones se concretan para los estándares biomédicos ISO/IEEE 11073 PHD y SCP-ECG. El tercer bloque propone nuevas formas de fortalecer la seguridad de los tests biomédicos, que constituyen el elemento esencial de muchas aplicaciones de m-Salud de carácter clínico, mediante codificaciones novedosas. Finalmente el cuarto bloque, que se sitúa en paralelo a los anteriores, selecciona herramientas genéricas de seguridad (elementos de autenticación y criptográficos) cuya integración en los otros bloques resulta idónea, y desarrolla nuevas herramientas de seguridad, basadas en señal -- embedding y keytagging --, para reforzar la protección de los test biomédicos.The paradigm of m-Health (mobile health) advocates for the massive integration of advanced mobile communications, network and sensor technologies in healthcare applications and systems to foster the deployment of a new, user/patient-centered healthcare model enabling the empowerment of users in the management of their health (e.g. by increasing their health literacy, promoting healthy lifestyles and the prevention of diseases), a better home-based healthcare delivery for elderly and chronic patients and important savings for healthcare systems due to the reduction of hospitalizations in number and duration. It is a fact that many m-Health applications demand high availability of biomedical information from their users (for further accurate analysis, e.g. by fusion of various signals) to guarantee high quality of service, which on the other hand entails increasing the potential surfaces for attacks. Therefore, it is not surprising that security (and privacy) is commonly included among the most important barriers for the success of m-Health. As a non-functional requirement for m-Health applications, security has received less attention than other technical issues that were more pressing at earlier development stages, such as reliability, eficiency, interoperability or usability. Another fact that has contributed to delaying the enforcement of robust security policies is that guaranteeing a certain security level implies costs that can be very relevant and that span along diferent dimensions. These include budgeting (e.g. the demand of extra hardware for user authentication), performance (e.g. lower eficiency and interoperability due to the addition of security elements) and usability (e.g. cumbersome configuration of devices and applications due to security options). Therefore, security solutions that aim to satisfy all the stakeholders in the m-Health context (users/patients, medical staff, technical staff, systems and devices manufacturers, regulators, etc.) shall be robust and, at the same time, minimize their associated costs. This Thesis details a proposal, composed of four interrelated blocks, to integrate appropriate levels of security in m-Health architectures in a cost-efcient manner. The first block designes a global scheme that provides different security and interoperability levels accordingto how critical are the m-Health applications to be implemented. This consists ofthree layers tailored to the m-Health domains and their constraints, whose security countermeasures defend against the threats of their associated m-Health applications. Next, the second block addresses the security extension of those standard protocols that enable the acquisition, exchange and/or management of biomedical information | thus, used by many m-Health applications | but do not meet the security levels described in the former scheme. These extensions are materialized for the biomedical standards ISO/IEEE 11073 PHD and SCP-ECG. Then, the third block proposes new ways of enhancing the security of biomedical standards, which are the centerpiece of many clinical m-Health applications, by means of novel codings. Finally the fourth block, with is parallel to the others, selects generic security methods (for user authentication and cryptographic protection) whose integration in the other blocks results optimal, and also develops novel signal-based methods (embedding and keytagging) for strengthening the security of biomedical tests. The layer-based extensions of the standards ISO/IEEE 11073 PHD and SCP-ECG can be considered as robust, cost-eficient and respectful with their original features and contents. The former adds no attributes to its data information model, four new frames to the service model |and extends four with new sub-frames|, and only one new sub-state to the communication model. Furthermore, a lightweight architecture consisting of a personal health device mounting a 9 MHz processor and an aggregator mounting a 1 GHz processor is enough to transmit a 3-lead electrocardiogram in real-time implementing the top security layer. The extra requirements associated to this extension are an initial configuration of the health device and the aggregator, tokens for identification/authentication of users if these devices are to be shared and the implementation of certain IHE profiles in the aggregator to enable the integration of measurements in healthcare systems. As regards to the extension of SCP-ECG, it only adds a new section with selected security elements and syntax in order to protect the rest of file contents and provide proper role-based access control. The overhead introduced in the protected SCP-ECG is typically 2{13 % of the regular file size, and the extra delays to protect a newly generated SCP-ECG file and to access it for interpretation are respectively a 2{10 % and a 5 % of the regular delays. As regards to the signal-based security techniques developed, the embedding method is the basis for the proposal of a generic coding for tests composed of biomedical signals, periodic measurements and contextual information. This has been adjusted and evaluated with electrocardiogram and electroencephalogram-based tests, proving the objective clinical quality of the coded tests, the capacity of the coding-access system to operate in real-time (overall delays of 2 s for electrocardiograms and 3.3 s for electroencephalograms) and its high usability. Despite of the embedding of security and metadata to enable m-Health services, the compression ratios obtained by this coding range from ' 3 in real-time transmission to ' 5 in offline operation. Complementarily, keytagging permits associating information to images (and other signals) by means of keys in a secure and non-distorting fashion, which has been availed to implement security measures such as image authentication, integrity control and location of tampered areas, private captioning with role-based access control, traceability and copyright protection. The tests conducted indicate a remarkable robustness-capacity tradeoff that permits implementing all this measures simultaneously, and the compatibility of keytagging with JPEG2000 compression, maintaining this tradeoff while setting the overall keytagging delay in only ' 120 ms for any image size | evidencing the scalability of this technique. As a general conclusion, it has been demonstrated and illustrated with examples that there are various, complementary and structured manners to contribute in the implementation of suitable security levels for m-Health architectures with a moderate cost in budget, performance, interoperability and usability. The m-Health landscape is evolving permanently along all their dimensions, and this Thesis aims to do so with its security. Furthermore, the lessons learned herein may offer further guidance for the elaboration of more comprehensive and updated security schemes, for the extension of other biomedical standards featuring low emphasis on security or privacy, and for the improvement of the state of the art regarding signal-based protection methods and applications

Towards a data-driven treatment of epilepsy: computational methods to overcome low-data regimes in clinical settings

Epilepsy is the most common neurological disorder, affecting around 1 % of the population. One third of patients with epilepsy are drug-resistant. If the epileptogenic zone can be localized precisely, curative resective surgery may be performed. However, only 40 to 70 % of patients remain seizure-free after surgery. Presurgical evaluation, which in part aims to localize the epileptogenic zone (EZ), is a complex multimodal process that requires subjective clinical decisions, often relying on a multidisciplinary team’s experience. Thus, the clinical pathway could benefit from data-driven methods for clinical decision support. In the last decade, deep learning has seen great advancements due to the improvement of graphics processing units (GPUs), the development of new algorithms and the large amounts of generated data that become available for training. However, using deep learning in clinical settings is challenging as large datasets are rare due to privacy concerns and expensive annotation processes. Methods to overcome the lack of data are especially important in the context of presurgical evaluation of epilepsy, as only a small proportion of patients with epilepsy end up undergoing surgery, which limits the availability of data to learn from. This thesis introduces computational methods that pave the way towards integrating data-driven methods into the clinical pathway for the treatment of epilepsy, overcoming the challenge presented by the relatively small datasets available. We used transfer learning from general-domain human action recognition to characterize epileptic seizures from video–telemetry data. We developed a software framework to predict the location of the epileptogenic zone given seizure semiologies, based on retrospective information from the literature. We trained deep learning models using self-supervised and semi-supervised learning to perform quantitative analysis of resective surgery by segmenting resection cavities on brain magnetic resonance images (MRIs). Throughout our work, we shared datasets and software tools that will accelerate research in medical image computing, particularly in the field of epilepsy

Transformées basées graphes pour la compression de nouvelles modalités d’image

Due to the large availability of new camera types capturing extra geometrical information, as well as the emergence of new image modalities such as light fields and omni-directional images, a huge amount of high dimensional data has to be stored and delivered. The ever growing streaming and storage requirements of these new image modalities require novel image coding tools that exploit the complex structure of those data. This thesis aims at exploring novel graph based approaches for adapting traditional image transform coding techniques to the emerging data types where the sampled information are lying on irregular structures. In a first contribution, novel local graph based transforms are designed for light field compact representations. By leveraging a careful design of local transform supports and a local basis functions optimization procedure, significant improvements in terms of energy compaction can be obtained. Nevertheless, the locality of the supports did not permit to exploit long term dependencies of the signal. This led to a second contribution where different sampling strategies are investigated. Coupled with novel prediction methods, they led to very prominent results for quasi-lossless compression of light fields. The third part of the thesis focuses on the definition of rate-distortion optimized sub-graphs for the coding of omni-directional content. If we move further and give more degree of freedom to the graphs we wish to use, we can learn or define a model (set of weights on the edges) that might not be entirely reliable for transform design. The last part of the thesis is dedicated to theoretically analyze the effect of the uncertainty on the efficiency of the graph transforms.En raison de la grande disponibilité de nouveaux types de caméras capturant des informations géométriques supplémentaires, ainsi que de l'émergence de nouvelles modalités d'image telles que les champs de lumière et les images omnidirectionnelles, il est nécessaire de stocker et de diffuser une quantité énorme de hautes dimensions. Les exigences croissantes en matière de streaming et de stockage de ces nouvelles modalités d’image nécessitent de nouveaux outils de codage d’images exploitant la structure complexe de ces données. Cette thèse a pour but d'explorer de nouvelles approches basées sur les graphes pour adapter les techniques de codage de transformées d'image aux types de données émergents où les informations échantillonnées reposent sur des structures irrégulières. Dans une première contribution, de nouvelles transformées basées sur des graphes locaux sont conçues pour des représentations compactes des champs de lumière. En tirant parti d’une conception minutieuse des supports de transformées locaux et d’une procédure d’optimisation locale des fonctions de base , il est possible d’améliorer considérablement le compaction d'énergie. Néanmoins, la localisation des supports ne permettait pas d'exploiter les dépendances à long terme du signal. Cela a conduit à une deuxième contribution où différentes stratégies d'échantillonnage sont étudiées. Couplés à de nouvelles méthodes de prédiction, ils ont conduit à des résultats très importants en ce qui concerne la compression quasi sans perte de champs de lumière statiques. La troisième partie de la thèse porte sur la définition de sous-graphes optimisés en distorsion de débit pour le codage de contenu omnidirectionnel. Si nous allons plus loin et donnons plus de liberté aux graphes que nous souhaitons utiliser, nous pouvons apprendre ou définir un modèle (ensemble de poids sur les arêtes) qui pourrait ne pas être entièrement fiable pour la conception de transformées. La dernière partie de la thèse est consacrée à l'analyse théorique de l'effet de l'incertitude sur l'efficacité des transformées basées graphes

Multimodal Biometric Systems for Personal Identification and Authentication using Machine and Deep Learning Classifiers

Multimodal biometrics, using machine and deep learning, has recently gained interest over single biometric modalities. This interest stems from the fact that this technique improves recognition and, thus, provides more security. In fact, by combining the abilities of single biometrics, the fusion of two or more biometric modalities creates a robust recognition system that is resistant to the flaws of individual modalities. However, the excellent recognition of multimodal systems depends on multiple factors, such as the fusion scheme, fusion technique, feature extraction techniques, and classification method. In machine learning, existing works generally use different algorithms for feature extraction of modalities, which makes the system more complex. On the other hand, deep learning, with its ability to extract features automatically, has made recognition more efficient and accurate. Studies deploying deep learning algorithms in multimodal biometric systems tried to find a good compromise between the false acceptance and the false rejection rates (FAR and FRR) to choose the threshold in the matching step. This manual choice is not optimal and depends on the expertise of the solution designer, hence the need to automatize this step. From this perspective, the second part of this thesis details an end-to-end CNN algorithm with an automatic matching mechanism. This thesis has conducted two studies on face and iris multimodal biometric recognition. The first study proposes a new feature extraction technique for biometric systems based on machine learning. The iris and facial features extraction is performed using the Discrete Wavelet Transform (DWT) combined with the Singular Value Decomposition (SVD). Merging the relevant characteristics of the two modalities is used to create a pattern for an individual in the dataset. The experimental results show the robustness of our proposed technique and the efficiency when using the same feature extraction technique for both modalities. The proposed method outperformed the state-of-the-art and gave an accuracy of 98.90%. The second study proposes a deep learning approach using DensNet121 and FaceNet for iris and faces multimodal recognition using feature-level fusion and a new automatic matching technique. The proposed automatic matching approach does not use the threshold to ensure a better compromise between performance and FAR and FRR errors. However, it uses a trained multilayer perceptron (MLP) model that allows people’s automatic classification into two classes: recognized and unrecognized. This platform ensures an accurate and fully automatic process of multimodal recognition. The results obtained by the DenseNet121-FaceNet model by adopting feature-level fusion and automatic matching are very satisfactory. The proposed deep learning models give 99.78% of accuracy, and 99.56% of precision, with 0.22% of FRR and without FAR errors. The proposed and developed platform solutions in this thesis were tested and vali- dated in two different case studies, the central pharmacy of Al-Asria Eye Clinic in Dubai and the Abu Dhabi Police General Headquarters (Police GHQ). The solution allows fast identification of the persons authorized to access the different rooms. It thus protects the pharmacy against any medication abuse and the red zone in the military zone against the unauthorized use of weapons