Simulation modelling and strategic change : creating the sustainable enterprise

Peer reviewedPublisher PD

Discrete Event Simulation Modelling for Dynamic Decision Making in Biopharmaceutical Manufacturing

With the increase in demand for biopharmaceutical products, industries have realised the need to scale up their manufacturing from laboratory-based processes to financially viable production processes. In this context, biopharmaceutical manufacturers are increasingly using simulation-based approaches to gain transparency of their current production system and to assist with designing improved systems. This paper discusses the application of Discrete Event Simulation (DES) and its ability to model the various scenarios for dynamic decision making in biopharmaceutical manufacturing sector. This paper further illustrates a methodology used to develop a simulation model for a biopharmaceutical company, which is considering several capital investments to improve its manufacturing processes. A simulation model for a subset of manufacturing activities was developed that facilitated ‘what-if’ scenario planning for a proposed process alternative. The simulation model of the proposed manufacturing process has shown significant improvement over the current process in terms of throughout time reduction, better resource utilisation, operating cost reduction, reduced bottlenecks etc. This visibility of the existing and proposed production system assisted the company in identifying the potential capital and efficiency gains from the investments therefore demonstrating that DES can be an effective tool for making more informed decisions. Furthermore, the paper also discusses the utilisation of DES models to develop a number of bespoke productivity improvement tools for the company

Engine performance characteristics and evaluation of variation in the length of intake plenum

In the engine with multipoint fuel injection system using electronically controlled fuel injectors has an intake manifold in which only the air flows and, the fuel is injected into the intake valve. Since the intake manifolds transport mainly air, the supercharging effects of the variable length intake plenum will be different from carbureted engine. Engine tests have been carried out with the aim of constituting a base study to design a new variable length intake manifold plenum. The objective in this research is to study the engine performance characteristics and to evaluate the effects of the variation in the length of intake plenum. The engine test bed used for experimental work consists of a control panel, a hydraulic dynamometer and measurement instruments to measure the parameters of engine performance characteristics. The control panel is being used to perform administrative and management operating system. Besides that, the hydraulic dynamometer was used to measure the power of an engine by using a cell filled with liquid to increase its load. Thus, measurement instrument is provided in this test to measure the as brake torque, brake power, thermal efficiency and specific fuel consumption. The results showed that the variation in the plenum length causes an improvement on the engine performance characteristics especially on the fuel consumption at high load and low engine speeds which are put forward the system using for urban roads. From this experiment, it will show the behavior of engine performance

A survey of simulation techniques in commerce and defence

Despite the developments in Modelling and Simulation (M&S) tools and techniques over the past years, there has been a gap in the M&S research and practice in healthcare on developing a toolkit to assist the modellers and simulation practitioners with selecting an appropriate set of techniques. This study is a preliminary step towards this goal. This paper presents some results from a systematic literature survey on applications of M&S in the commerce and defence domains that could inspire some improvements in the healthcare. Interim results show that in the commercial sector Discrete-Event Simulation (DES) has been the most widely used technique with System Dynamics (SD) in second place. However in the defence sector, SD has gained relatively more attention. SD has been found quite useful for qualitative and soft factors analysis. From both the surveys it becomes clear that there is a growing trend towards using hybrid M&S approaches

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Energy efficiency in discrete-manufacturing systems: insights, trends, and control strategies

Since the depletion of fossil energy sources, rising energy prices, and governmental regulation restrictions, the current manufacturing industry is shifting towards more efficient and sustainable systems. This transformation has promoted the identification of energy saving opportunities and the development of new technologies and strategies oriented to improve the energy efficiency of such systems. This paper outlines and discusses most of the research reported during the last decade regarding energy efficiency in manufacturing systems, the current technologies and strategies to improve that efficiency, identifying and remarking those related to the design of management/control strategies. Based on this fact, this paper aims to provide a review of strategies for reducing energy consumption and optimizing the use of resources within a plant into the context of discrete manufacturing. The review performed concerning the current context of manufacturing systems, control systems implemented, and their transformation towards Industry 4.0 might be useful in both the academic and industrial dimension to identify trends and critical points and suggest further research lines.Peer ReviewedPreprin

Modeling of Structural Adjustment Processes of Farming Enterprises: The Need for Implementation of Cooperation and Collaboration Strategies

The research objective is to shed light on the structural adjustment process of farming enterprises in Switzerland. To this end, an analytical tool is developed which allows us to identify the most important influencing factors and to estimate in advance their effects on the structural adjustment process. The resulting structures will be compared with the relevant goals of the (agricultural) policy in order to draw conclusions about the effectiveness of the adjustment process. Using scenario techniques combined with an agent-based simulation, the influencing factors are varied to investigate alternative options like cooperation and collaboration strategies for improving the effectiveness with respect to the social, ecological and economic goals.Agent-based simulation, structural change, cooperation strategies, collaboration, Agricultural Finance, C61, Q12, Q15,

MODELING OF AGRICULTURAL SYSTEMS

The authors present an overview of agricultural systems models. Beginning with why systems are modeled and for what purposes, the paper examines types of agricultural systems and associated model types. The broad categories range from pictorial (iconic) models to descriptive analogue models to symbolic (usually mathematical) models. The uses of optimization versus non-optimizing mechanistic models are reviewed, as are the scale and aggregation challenges associated with scaling up from the plant cell to the landscape or from a farm enterprise to a world market supply-demand equilibrium Recent modeling developments include the integration of formerly stand-alone biophysical simulation models, increasingly with a unifying spatial database and often for the purpose of supporting management decisions. Current modeling innovations are estimating and incorporating environmental values and other system interactions. At the community and regional scale, sociological and economic models of rural community structure are being developed to evaluate long-term community viability. The information revolution is bringing new challenges in delivering agricultural systems models over the internet, as well as integrating decision support systems with the new precision agriculture technologies.Farm Management,