16,438 research outputs found
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
Power Management Techniques for Data Centers: A Survey
With growing use of internet and exponential growth in amount of data to be
stored and processed (known as 'big data'), the size of data centers has
greatly increased. This, however, has resulted in significant increase in the
power consumption of the data centers. For this reason, managing power
consumption of data centers has become essential. In this paper, we highlight
the need of achieving energy efficiency in data centers and survey several
recent architectural techniques designed for power management of data centers.
We also present a classification of these techniques based on their
characteristics. This paper aims to provide insights into the techniques for
improving energy efficiency of data centers and encourage the designers to
invent novel solutions for managing the large power dissipation of data
centers.Comment: Keywords: Data Centers, Power Management, Low-power Design, Energy
Efficiency, Green Computing, DVFS, Server Consolidatio
Computation in Classical Mechanics
There is a growing consensus that physics majors need to learn computational
skills, but many departments are still devoid of computation in their physics
curriculum. Some departments may lack the resources or commitment to create a
dedicated course or program in computational physics. One way around this
difficulty is to include computation in a standard upper-level physics course.
An intermediate classical mechanics course is particularly well suited for
including computation. We discuss the ways we have used computation in our
classical mechanics courses, focusing on how computational work can improve
students' understanding of physics as well as their computational skills. We
present examples of computational problems that serve these two purposes. In
addition, we provide information about resources for instructors who would like
to include computation in their courses.Comment: 6 pages, 3 figures, submitted to American Journal of Physic
From Quantity to Quality: Massive Molecular Dynamics Simulation of Nanostructures under Plastic Deformation in Desktop and Service Grid Distributed Computing Infrastructure
The distributed computing infrastructure (DCI) on the basis of BOINC and
EDGeS-bridge technologies for high-performance distributed computing is used
for porting the sequential molecular dynamics (MD) application to its parallel
version for DCI with Desktop Grids (DGs) and Service Grids (SGs). The actual
metrics of the working DG-SG DCI were measured, and the normal distribution of
host performances, and signs of log-normal distributions of other
characteristics (CPUs, RAM, and HDD per host) were found. The practical
feasibility and high efficiency of the MD simulations on the basis of DG-SG DCI
were demonstrated during the experiment with the massive MD simulations for the
large quantity of aluminum nanocrystals (-). Statistical
analysis (Kolmogorov-Smirnov test, moment analysis, and bootstrapping analysis)
of the defect density distribution over the ensemble of nanocrystals had shown
that change of plastic deformation mode is followed by the qualitative change
of defect density distribution type over ensemble of nanocrystals. Some
limitations (fluctuating performance, unpredictable availability of resources,
etc.) of the typical DG-SG DCI were outlined, and some advantages (high
efficiency, high speedup, and low cost) were demonstrated. Deploying on DG DCI
allows to get new scientific from the simulated
of numerous configurations by harnessing sufficient computational power to
undertake MD simulations in a wider range of physical parameters
(configurations) in a much shorter timeframe.Comment: 13 pages, 11 pages (http://journals.agh.edu.pl/csci/article/view/106
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