1,755 research outputs found
Automated detection of Alzheimer disease using MRI images and deep neural networks- A review
Early detection of Alzheimer disease is crucial for deploying interventions
and slowing the disease progression. A lot of machine learning and deep
learning algorithms have been explored in the past decade with the aim of
building an automated detection for Alzheimer. Advancements in data
augmentation techniques and advanced deep learning architectures have opened up
new frontiers in this field, and research is moving at a rapid speed. Hence,
the purpose of this survey is to provide an overview of recent research on deep
learning models for Alzheimer disease diagnosis. In addition to categorizing
the numerous data sources, neural network architectures, and commonly used
assessment measures, we also classify implementation and reproducibility. Our
objective is to assist interested researchers in keeping up with the newest
developments and in reproducing earlier investigations as benchmarks. In
addition, we also indicate future research directions for this topic.Comment: 22 Pages, 5 Figures, 7 Table
A Hybrid Transfer Learning Assisted Decision Support System for Accurate Prediction of Alzheimer Disease
Alzheimer's disease (AD) is the most common long-term illness in elderly
people. In recent years, deep learning has become popular in the area of
medical imaging and has had a lot of success there. It has become the most
effective way to look at medical images. When it comes to detecting AD, the
deep neural model is more accurate and effective than general machine learning.
Our research contributes to the development of a more comprehensive
understanding and detection of the disease by identifying four distinct classes
that are predictive of AD with a high weighted accuracy of 98.91%. A unique
strategy has been proposed to improve the accuracy of the imbalance dataset
classification problem via the combination of ensemble averaging models and
five different transfer learning models in this study.
EfficientNetB0+Resnet152(effnet+res152) and
InceptionV3+EfficientNetB0+Resnet50(incep+effnet+res50) models have been
fine-tuned and have reached the highest weighted accuracy for multi-class AD
stage classifications
Alzheimer’s And Parkinson’s Disease Classification Using Deep Learning Based On MRI: A Review
Neurodegenerative disorders present a current challenge for accurate diagnosis and for providing precise prognostic information. Alzheimer’s disease (AD) and Parkinson's disease (PD), may take several years to obtain a definitive diagnosis. Due to the increased aging population in developed countries, neurodegenerative diseases such as AD and PD have become more prevalent and thus new technologies and more accurate tests are needed to improve and accelerate the diagnostic procedure in the early stages of these diseases. Deep learning has shown significant promise in computer-assisted AD and PD diagnosis based on MRI with the widespread use of artificial intelligence in the medical domain. This article analyses and evaluates the effectiveness of existing Deep learning (DL)-based approaches to identify neurological illnesses using MRI data obtained using various modalities, including functional and structural MRI. Several current research issues are identified toward the conclusion, along with several potential future study directions
Towards Practical Application of Deep Learning in Diagnosis of Alzheimer's Disease
Accurate diagnosis of Alzheimer's disease (AD) is both challenging and time
consuming. With a systematic approach for early detection and diagnosis of AD,
steps can be taken towards the treatment and prevention of the disease. This
study explores the practical application of deep learning models for diagnosis
of AD. Due to computational complexity, large training times and limited
availability of labelled dataset, a 3D full brain CNN (convolutional neural
network) is not commonly used, and researchers often prefer 2D CNN variants. In
this study, full brain 3D version of well-known 2D CNNs were designed, trained
and tested for diagnosis of various stages of AD. Deep learning approach shows
good performance in differentiating various stages of AD for more than 1500
full brain volumes. Along with classification, the deep learning model is
capable of extracting features which are key in differentiating the various
categories. The extracted features align with meaningful anatomical landmarks,
that are currently considered important in identification of AD by experts. An
ensemble of all the algorithm was also tested and the performance of the
ensemble algorithm was superior to any individual algorithm, further improving
diagnosis ability. The 3D versions of the trained CNNs and their ensemble have
the potential to be incorporated in software packages that can be used by
physicians/radiologists to assist them in better diagnosis of AD.Comment: 18 pages, 8 figure
DEEP-AD: The deep learning model for diagnostic classification and prognostic prediction of alzheimer's disease
In terms of context, the aim of this dissertation is to aid neuroradiologists in their clinical judgment regarding the early detection of AD by using DL. To that aim, the system design research methodology is suggested in this dissertation for achieving three goals.
The first goal is to investigate the DL models that have performed well at identifying patterns associated with AD, as well as the accuracy so far attained, limitations, and gaps. A systematic review of the literature (SLR) revealed a shortage of empirical studies on the early identification of AD through DL. In this regard, thirteen empirical studies were identified and examined. We concluded that three-dimensional (3D) DL models have been generated far less often and that their performance is also inadequate to qualify them for clinical trials.
The second goal is to provide the neuroradiologist with the computer-interpretable information they need to analyze neuroimaging biomarkers. Given this context, the next step in this dissertation is to find the optimum DL model to analyze neuroimaging biomarkers. It has been achieved in
two steps. In the first step, eight state-of-the-art DL models have been implemented by training from scratch using end-to-end learning (E2EL) for two binary classification tasks (AD vs. CN and AD vs. stable MCI) and compared by utilizing MRI scans from the publicly accessible datasets of neuroimaging biomarkers. Comparative analysis is carried out by utilizing efficiency-effects graphs, comprehensive indicators, and ranking mechanisms. For the training of the AD vs. sMCI task, the EfficientNet-B0 model gets the highest value for the comprehensive indicator and has the fewest parameters. DenseNet264 performed better than the others in terms of evaluation matrices, but since it has the most parameters, it costs more to train. For the AD vs. CN task by DenseNet264, we achieved 100% accuracy for training and 99.56% accuracy for testing. However, the classification accuracy was still only 82.5% for the AD vs. sMCI task. In the second step, fusion of transfer learning (TL) with E2EL is applied to train the EfficientNet-B0 for the AD vs. sMCI task, which achieved 95.29% accuracy for training and 93.10% accuracy for testing. Additionally, we have also implemented EfficientNet-B0 for the multiclass AD vs. CN vs. sMCI classification task with E2EL to be used in ensemble of models and achieved 85.66% training accuracy and 87.38% testing accuracy.
To evaluate the model’s robustness, neuroradiologists must validate the implemented model. As a result, the third goal of this dissertation is to create a tool that neuroradiologists may use at their convenience. To achieve this objective, this dissertation proposes a web-based application (DEEP-AD) that has been created by making an ensemble of Efficient-Net B0 and DenseNet 264 (based on the contribution of goal 2).
The accuracy of a DEEP-AD prototype has undergone repeated evaluation and improvement. First, we validated 41 subjects of Spanish MRI datasets (acquired from HT Medica, Madrid, Spain), achieving an accuracy of 82.90%, which was later verified by neuroradiologists. The results of these evaluation studies showed the accomplishment of such goals and relevant directions for future research in applied DL for the early detection of AD in clinical settings.En términos de contexto, el objetivo de esta tesis es ayudar a los neurorradiólogos en su juicio clínico sobre la detección precoz de la AD mediante el uso de DL. Para ello, en esta tesis se propone la metodología de investigación de diseño de sistemas para lograr tres objetivos.
El segundo objetivo es proporcionar al neurorradiólogo la información interpretable por ordenador que necesita para analizar los biomarcadores de neuroimagen. Dado este contexto, el siguiente paso en esta tesis es encontrar el modelo DL óptimo para analizar biomarcadores de neuroimagen. Esto se ha logrado en dos pasos. En el primer paso, se han implementado ocho modelos DL de última generación mediante entrenamiento desde cero utilizando aprendizaje de extremo a extremo (E2EL) para dos tareas de clasificación binarias (AD vs. CN y AD vs. MCI estable) y se han comparado utilizando escaneos MRI de los conjuntos de datos de biomarcadores de neuroimagen de acceso público. El análisis comparativo se lleva a cabo utilizando gráficos de efecto-eficacia, indicadores exhaustivos y mecanismos de clasificación. Para el entrenamiento de la tarea AD vs. sMCI, el modelo EfficientNet-B0 obtiene el valor más alto para el indicador exhaustivo y tiene el menor número de parámetros. DenseNet264 obtuvo mejores resultados que los demás en términos de matrices de evaluación, pero al ser el que tiene más parámetros, su entrenamiento es más costoso. Para la tarea AD vs. CN de DenseNet264, conseguimos una accuracy del 100% en el entrenamiento y del 99,56% en las pruebas. Sin embargo, la accuracy de la clasificación fue sólo del 82,5% para la tarea AD vs. sMCI. En el segundo paso, se aplica la fusión del aprendizaje por transferencia (TL) con E2EL para entrenar la EfficientNet-B0 para la tarea AD vs. sMCI, que alcanzó una accuracy del 95,29% en el entrenamiento y del 93,10% en las pruebas. Además, también hemos implementado EfficientNet-B0 para la tarea de clasificación multiclase AD vs. CN vs. sMCI con E2EL para su uso en conjuntos de modelos y hemos obtenido una accuracy de entrenamiento del 85,66% y una precisión de prueba del 87,38%.
Para evaluar la solidez del modelo, los neurorradiólogos deben validar el modelo implementado. Como resultado, el tercer objetivo de esta disertación es crear una herramienta que los neurorradiólogos puedan utilizar a su conveniencia. Para lograr este objetivo, esta disertación propone una aplicación basada en web (DEEP-AD) que ha sido creada haciendo un ensemble de Efficient-Net B0 y DenseNet 264 (basado en la contribución del objetivo 2).
La accuracy del prototipo DEEP-AD ha sido sometida a repetidas evaluaciones y mejoras. En primer lugar, validamos 41 sujetos de conjuntos de datos de MRI españoles (adquiridos de HT Medica, Madrid, España), logrando una accuracy del 82,90%, que posteriormente fue verificada por neurorradiólogos. Los resultados de estos estudios de evaluación mostraron el cumplimiento de dichos objetivos y las direcciones relevantes para futuras investigaciones en DL, aplicada en la detección precoz de la AD en entornos clínicos.Escuela de DoctoradoDoctorado en Tecnologías de la Información y las Telecomunicacione
Alzheimer’s Disease Diagnosis Using CNN Based Pre-trained Models
Memory loss and impairment are signs of Alzheimer's disease (AD), which may also cause other issues. It has a significant impact on patients' lives and is incurable, but rapid recognition of Alzheimer's disease can be useful to initiate appropriate therapy to avoid further deterioration to the brain. Previously, Machine Learning methodswere used to detect Alzheimer's disease. In recent times, Deep Learning algorithms have become more popular for pattern recognition. This workconcentrates on the recognition of Alzheimer's disease at a preliminary phase using advanced convolutional neural network models. As the disease advances, they steadily forget everything. It is critical to detect the disease as quickly as possible. The proposed model usespre-trained models that uses magnetic resonance imaging of the brain to determine if a person has very mild, mild, moderate, or non-dementia. The models used for classification are VGG16, VGG19, and ResNet50 architectures and provide performance comparison
DETERMINING EFFECTIVE LEVEL OF DEMENTIA DISEASE USING MRI IMAGES
Abstract
The prevalence of dementia is growing as the world's population ages, making it a major public health issue. The key to successful management and treatment of dementia is an early and precise diagnosis. In this work, we will investigate the Dementia detection model DenseNet-169 in depth. The DenseNet-169 model has been used to classify almost 7,000 magnetic resonance imaging (MRI) scans of the brain. Non-Dementia, Mild Dementia, Severe Dementia, and Moderate Dementia are all categorized using this Convolution Neural Network (CNN) model. The use of deep learning and image processing presents intriguing new directions for the diagnosis and treatment of dementia, with the ultimate goal of enhancing the quality of life for those with the disease
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