MINOR HISTORICAL CENTRES ONTOLOGY ENRICHMENT AND POPULATION: AN HAMLET CASE STUDY

The main topic of this work focuses on the semantic, historical and spatial documentation of Minor Historical Centres (MHC) with a focus on (semi-abandoned alpine) hamlets. The key point is the possibility to standardise spatial information in the domain of MHC and their related cultural, architectural, built and landscape heritage. This work analyses the notions of historical centre and ancient area, which took different meanings and evolved over the centuries. MHC are historical part of cities, villages and hamlets (urban, rural, minor or abandoned) with cultural, social and economic values. Thus, MHC need to be preserved, documented and safeguarded. The spatial and semantic documentation is a fundamental tool for increasing their knowledge. In these places, many actors and stakeholders are involved in different activities, and for this reason, they need to share common knowledge and use a unique language. In this regard, spatial ontology is of relevant interest and usability. Ontologies are conceptual structures that formalise specific knowledge and create a unique and standard thesaurus that ensures semantic interoperability. This paper is part of a PhD research targeted at developing an ontology containing helpful information to manage, share and collect data on MHC due to the lack of an interoperable structure to formalise such knowledge. The main aim is to populate and enrich the already developed ontological structure with data of a mountain semi-abandoned hamlet: Pomieri. The methodological workflow is validated, enriching and populating the ontology, adding classes and instances with information and unstructured data of a real data case study

Automatic domain-specific learning: towards a methodology for ontology enrichment

[EN] At the current rate of technological development, in a world where enormous amount of data are constantly created and in which the Internet is used as the primary means for information exchange, there exists a need for tools that help processing, analyzing and using that information. However, while the growth of information poses many opportunities for social and scientific advance, it has also highlighted the difficulties of extracting meaningful patterns from massive data. Ontologies have been claimed to play a major role in the processing of large-scale data, as they serve as universal models of knowledge representation, and are being studied as possible solutions to this. This paper presents a method for the automatic expansion of ontologies based on corpus and terminological data exploitation. The proposed ¿ontology enrichment method¿ (OEM) consists of a sequence of tasks aimed at classifying an input keyword automatically under its corresponding node within a target ontology. Results prove that the method can be successfully applied for the automatic classification of specialized units into a reference ontology.Financial support for this research has been provided by the DGI, Spanish Ministry of Education and Science, grant FFI2011-29798-C0201.Ureña Gómez-Moreno, P.; Mestre-Mestre, EM. (2017). Automatic domain-specific learning: towards a methodology for ontology enrichment. LFE. Revista de Lenguas para Fines Específicos. 23(2):63-85. http://hdl.handle.net/10251/148357S638523

Lifecycle-Support in Architectures for Ontology-Based Information Systems

Ontology-based applications play an increasingly important role in the public and corporate Semantic Web. While today there exist a range of tools and technologies to support specific ontology engineering and management activities, architectural design guidelines for building ontology-based applications are missing. In this paper, we present an architecture for ontology-based applications—covering the complete ontology-lifecycle—that is intended to support software engineers in designing and developing ontology based-applications. We illustrate the use of the architecture in a concrete case study using the NeOn toolkit as one implementation of the architecture

Mapping longitudinal studies to risk factors in an ontology for dementia

A common activity carried out by healthcare professionals is to test various hypotheses on longitudinal study data in an effort to develop new and more reliable algorithms that might determine the possibility of developing certain illnesses. The In-MINDD project provides input from a number of European dementia experts to identify the most accurate model of inter-related risk factors which can yield a personalised dementia risk quotient and profile. This model is then validated against the large population-based prospective Maastricht Aging Study (MAAS) dataset. As part of this overall goal, the research presented in this paper demonstrates how we can automate the process of mapping modifiable risk factors against large sections of the aging study and thus, use information technology to provide more powerful query interfaces

Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes

Skeletal muscle insulin resistance (IR) is considered a critical component of type II diabetes, yet to date IR has evaded characterization at the global gene expression level in humans. MicroRNAs (miRNAs) are considered fine-scale rheostats of protein-coding gene product abundance. The relative importance and mode of action of miRNAs in human complex diseases remains to be fully elucidated. We produce a global map of coding and non-coding RNAs in human muscle IR with the aim of identifying novel disease biomarkers. We profiled >47,000 mRNA sequences and >500 human miRNAs using gene-chips and 118 subjects (n = 71 patients versus n = 47 controls). A tissue-specific gene-ranking system was developed to stratify thousands of miRNA target-genes, removing false positives, yielding a weighted inhibitor score, which integrated the net impact of both up- and down-regulated miRNAs. Both informatic and protein detection validation was used to verify the predictions of in vivo changes. The muscle mRNA transcriptome is invariant with respect to insulin or glucose homeostasis. In contrast, a third of miRNAs detected in muscle were altered in disease (n = 62), many changing prior to the onset of clinical diabetes. The novel ranking metric identified six canonical pathways with proven links to metabolic disease while the control data demonstrated no enrichment. The Benjamini-Hochberg adjusted Gene Ontology profile of the highest ranked targets was metabolic (P < 7.4 × 10-8), post-translational modification (P < 9.7 × 10-5) and developmental (P < 1.3 × 10-6) processes. Protein profiling of six development-related genes validated the predictions. Brain-derived neurotrophic factor protein was detectable only in muscle satellite cells and was increased in diabetes patients compared with controls, consistent with the observation that global miRNA changes were opposite from those found during myogenic differentiation. We provide evidence that IR in humans may be related to coordinated changes in multiple microRNAs, which act to target relevant signaling pathways. It would appear that miRNAs can produce marked changes in target protein abundance in vivo by working in a combinatorial manner. Thus, miRNA detection represents a new molecular biomarker strategy for insulin resistance, where micrograms of patient material is needed to monitor efficacy during drug or life-style interventions

Semantic adaptability for the systems interoperability

In the current global and competitive business context, it is essential that enterprises adapt their knowledge resources in order to smoothly interact and collaborate with others. However, due to the existent multiculturalism of people and enterprises, there are different representation views of business processes or products, even inside a same domain. Consequently, one of the main problems found in the interoperability between enterprise systems and applications is related to semantics. The integration and sharing of enterprises knowledge to build a common lexicon, plays an important role to the semantic adaptability of the information systems. The author proposes a framework to support the development of systems to manage dynamic semantic adaptability resolution. It allows different organisations to participate in a common knowledge base building, letting at the same time maintain their own views of the domain, without compromising the integration between them. Thus, systems are able to be aware of new knowledge, and have the capacity to learn from it and to manage its semantic interoperability in a dynamic and adaptable way. The author endorses the vision that in the near future, the semantic adaptability skills of the enterprise systems will be the booster to enterprises collaboration and the appearance of new business opportunities