Advances in Digital Processing of Low-Amplitude Components of Electrocardiosignals

This manual has been published within the framework of the BME-ENA project under the responsibility of National Technical University of Ukraine. The BME-ENA “Biomedical Engineering Education Tempus Initiative in Eastern Neighbouring Area”, Project Number: 543904-TEMPUS-1-2013-1-GR-TEMPUS-JPCR is a Joint Project within the TEMPUS IV program. This project has been funded with support from the European Commission.Навчальний посібник присвячено розробці методів та засобів для неінвазивного виявлення та дослідження тонких проявів електричної активності серця. Особлива увага приділяється вдосконаленню інформаційного та алгоритмічного забезпечення систем електрокардіографії високого розрізнення для ранньої діагностики електричної нестабільності міокарда, а також для оцінки функціонального стану плоду під час вагітності. Теоретичні основи супроводжуються прикладами реалізації алгоритмів за допомогою системи MATLAB. Навчальний посібник призначений для студентів, аспірантів, а також фахівців у галузі біомедичної електроніки та медичних працівників.The teaching book is devoted to development and research of methods and tools for non-invasive detection of subtle manifistations of heart electrical activity. Particular attention is paid to the improvement of information and algorithmic support of high resolution electrocardiography for early diagnosis of myocardial electrical instability, as well as for the evaluation of the functional state of the fetus during pregnancy examination. The theoretical basis accompanied by the examples of implementation of the discussed algorithms with the help of MATLAB. The teaching book is intended for students, graduate students, as well as specialists in the field of biomedical electronics and medical professionals

A Genome-Wide Analysis of Array-Based Comparative Genomic Hybridization (CGH) Data to Detect Intra-Species Variations and Evolutionary Relationships

Array-based comparative genomics hybridization (aCGH) has gained prevalence as an effective technique for measuring structural variations in the genome. Copy-number variations (CNVs) form a large source of genomic structural variation, but it is not known whether phenotypic differences between intra-species groups, such as divergent human populations, or breeds of a domestic animal, can be attributed to CNVs. Several computational methods have been proposed to improve the detection of CNVs from array CGH data, but few population studies have used CGH data for identification of intra-species differences. In this paper we propose a novel method of genome-wide comparison and classification using CGH data that condenses whole genome information, aimed at quantification of intra-species variations and discovery of shared ancestry. Our strategy included smoothing CGH data using an appropriate denoising algorithm, extracting features via wavelets, quantifying the information via wavelet power spectrum and hierarchical clustering of the resultant profile. To evaluate the classification efficiency of our method, we used simulated data sets. We applied it to aCGH data from human and bovine individuals and showed that it successfully detects existing intra-specific variations with additional evolutionary implications

Machine Learning Methods for Better Water Quality Prediction

In any aquatic system analysis, the modelling water quality parameters are of considerable significance. The traditional modelling methodologies are dependent on datasets that involve large amount of unknown or unspecified input data and generally consist of time-consuming processes. The implementation of artificial intelligence (AI) leads to a flexible mathematical structure that has the capability to identify non-linear and complex relationships between input and output data. There has been a major degradation of the Johor River Basin because of several developmental and human activities. Therefore, setting up of a water quality prediction model for better water resource management is of critical importance and will serve as a powerful tool. The different modelling approaches that have been implemented include: Adaptive Neuro-Fuzzy Inference System (ANFIS), Radial Basis Function Neural Networks (RBF-ANN), and Multi-Layer Perceptron Neural Networks (MLP-ANN). However, data obtained from monitoring stations and experiments are possibly polluted by noise signals as a result of random and systematic errors. Due to the presence of noise in the data, it is relatively difficult to make an accurate prediction. Hence, a Neuro-Fuzzy Inference System (WDT-ANFIS) based augmented wavelet de-noising technique has been recommended that depends on historical data of the water quality parameter. In the domain of interests, the water quality parameters primarily include ammoniacal nitrogen (AN), suspended solid (SS) and pH. In order to evaluate the impacts on the model, three evaluation techniques or assessment processes have been used. The first assessment process is dependent on the partitioning of the neural network connection weights that ascertains the significance of every input parameter in the network. On the other hand, the second and third assessment processes ascertain the most effectual input that has the potential to construct the models using a single and a combination of parameters, respectively. During these processes, two scenarios were introduced: Scenario 1 and Scenario 2. Scenario 1 constructs a prediction model for water quality parameters at every station, while Scenario 2 develops a prediction model on the basis of the value of the same parameter at the previous station (upstream). Both the scenarios are based on the value of the twelve input parameters. The field data from 2009 to 2010 was used to validate WDT-ANFIS. The WDT-ANFIS model exhibited a significant improvement in predicting accuracy for all the water quality parameters and outperformed all the recommended models. Also, the performance of Scenario 2 was observed to be more adequate than Scenario 1, with substantial improvement in the range of 0.5% to 5% for all the water quality parameters at all stations. On validating the recommended model, it was found that the model satisfactorily predicted all the water quality parameters (R2 values equal or bigger than 0.9). © 201

Enhancement of time-frequency properties of ECG for detecting micropotentials by wavelet transform. based method

WOS: 000250295300076Time-frequency distributions have been widely utilized in the analysis of transients' nature of biomedical signals. In these applications, the time-frequency components with very small amplitude values cannot be displayed clearly. This drawback results from a masking effect on these components by the presence of high-energy slow waves and sharp patterns in the signal that produces large values in the time-frequency distributions. In this paper, we proposed an effective signal preprocessing method-using kurtosis-based denoising of wavelet coefficients. This method enhances the time-frequency distributions so that the masking effect is greatly reduced, while the original time-frequency signatures of the input signal are preserved. Experimental studies on ECG signal coming from MIT-BIH database, with and without preprocessing methods have shown a clear improvement in observability and sensivity in the time-frequency distributions. (c) 2006 Elsevier Ltd. All rights reserved

Enhancement of time-frequency properties of ECG for detecting micropotentials by wavelet transform based method

Time-frequency distributions have been widely utilized in the analysis of transients' nature of biomedical signals. In these applications, the time-frequency components with very small amplitude values cannot be displayed clearly. This drawback results from a masking effect on these components by the presence of high-energy slow waves and sharp patterns in the signal that produces large values in the time-frequency distributions. In this paper, we proposed an effective signal preprocessing method-using kurtosis-based denoising of wavelet coefficients. This method enhances the time-frequency distributions so that the masking effect is greatly reduced, while the original time-frequency signatures of the input signal are preserved. Experimental studies on ECG signal coming from MIT-BIH database, with and without preprocessing methods have shown a clear improvement in observability and sensivity in the time-frequency distributions. © 2006 Elsevier Ltd. All rights reserved