Sparse feature learning for image analysis in segmentation, classification, and disease diagnosis.

The success of machine learning algorithms generally depends on intermediate data representation, called features that disentangle the hidden factors of variation in data. Moreover, machine learning models are required to be generalized, in order to reduce the specificity or bias toward the training dataset. Unsupervised feature learning is useful in taking advantage of large amount of unlabeled data, which is available to capture these variations. However, learned features are required to capture variational patterns in data space. In this dissertation, unsupervised feature learning with sparsity is investigated for sparse and local feature extraction with application to lung segmentation, interpretable deep models, and Alzheimer\u27s disease classification. Nonnegative Matrix Factorization, Autoencoder and 3D Convolutional Autoencoder are used as architectures or models for unsupervised feature learning. They are investigated along with nonnegativity, sparsity and part-based representation constraints for generalized and transferable feature extraction

Methods and Techniques for Clinical Text Modeling and Analytics

Nowadays, a large portion of clinical data only exists in free text. The wide adoption of Electronic Health Records (EHRs) has enabled the increases in accessing to clinical documents, which provide challenges and opportunities for clinical Natural Language Processing (NLP) researchers. Given free-text clinical notes as input, an ideal system for clinical text understanding should have the ability to support clinical decisions. At corpus level, the system should recommend similar notes based on disease or patient types, and provide medication recommendation, or any other type of recommendations, based on patients' symptoms and other similar medical cases. At document level, it should return a list of important clinical concepts. Moreover, the system should be able to make diagnostic inferences over clinical concepts and output diagnosis. Unfortunately, current work has not systematically studied this system. This study focuses on developing and applying methods/techniques in different aspects of the system for clinical text understanding, at both corpus and document level. We deal with two major research questions: First, we explore the question of How to model the underlying relationships from clinical notes at corpus level? Documents clustering methods can group clinical notes into meaningful clusters, which can assist physicians and patients to understand medical conditions and diseases from clinical notes. We use Nonnegative Matrix Factorization (NMF) and Multi-view NMF to cluster clinical notes based on extracted medical concepts. The clustering results display latent patterns existed among clinical notes. Our method provides a feasible way to visualize a corpus of clinical documents. Based on extracted concepts, we further build a symptom-medication (Symp-Med) graph to model the Symp-Med relations in clinical notes corpus. We develop two Symp-Med matching algorithms to predict and recommend medications for patients based on their symptoms. Second, we want to solve the question of How to integrate structured knowledge with unstructured text to improve results for Clinical NLP tasks? On the one hand, the unstructured clinical text contains lots of information about medical conditions. On the other hand, structured Knowledge Bases (KBs) are frequently used for supporting clinical NLP tasks. We propose graph-regularized word embedding models to integrate knowledge from both KBs and free text. We evaluate our models on standard datasets and biomedical NLP tasks, and results showed encouraging improvements on both datasets. We further apply the graph-regularized word embedding models and present a novel approach to automatically infer the most probable diagnosis from a given clinical narrative.Ph.D., Information Studies -- Drexel University, 201

Diversity control for improving the analysis of consensus clustering

Consensus clustering has emerged as a powerful technique for obtaining better clustering results, where a set of data partitions (ensemble) are generated, which are then combined to obtain a consolidated solution (consensus partition) that outperforms all of the members of the input set. The diversity of ensemble partitions has been found to be a key aspect for obtaining good results, but the conclusions of previous studies are contradictory. Therefore, ensemble diversity analysis is currently an important issue because there are no methods for smoothly changing the diversity of an ensemble, which makes it very difficult to study the impact of ensemble diversity on consensus results. Indeed, ensembles with similar diversity can have very different properties, thereby producing a consensus function with unpredictable behavior. In this study, we propose a novel method for increasing and decreasing the diversity of data partitions in a smooth manner by adjusting a single parameter, thereby achieving fine-grained control of ensemble diversity. The results obtained using well-known data sets indicate that the proposed method is effective for controlling the dissimilarity among ensemble members to obtain a consensus function with smooth behavior. This method is important for facilitating the analysis of the impact of ensemble diversity in consensus clustering.Fil: Pividori, Milton Damián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentina. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Centro de Investigación y Desarrollo de Ingeniería en Sistemas de Información; ArgentinaFil: Stegmayer, Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; ArgentinaFil: Milone, Diego Humberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentin

Topic Modeling for Automatic Analysis of Natural Language: A Case Study in an Italian Customer Support Center

This paper focuses on the automatic analysis of conversation transcriptions in the call center of a customer care service. The goal is to recognize topics related to problems and complaints discussed in several dialogues between customers and agents. Our study aims to implement a framework able to automatically cluster conversation transcriptions into cohesive and well-separated groups based on the content of the data. The framework can alleviate the analyst selecting proper values for the analysis and the clustering processes. To pursue this goal, we consider a probabilistic model based on the latent Dirichlet allocation, which associates transcriptions with a mixture of topics in different proportions. A case study consisting of transcriptions in the Italian natural language, and collected in a customer support center of an energy supplier, is considered in the paper. Performance comparison of different inference techniques is discussed using the case study. The experimental results demonstrate the approach’s efficacy in clustering Italian conversation transcriptions. It also results in a practical tool to simplify the analytic process and off-load the parameter tuning from the end-user. According to recent works in the literature, this paper may be valuable for introducing latent Dirichlet allocation approaches in topic modeling for the Italian natural language

Recommender system to support comprehensive exploration of large scale scientific datasets

Bases de dados de entidades científicas, como compostos químicos, doenças e objetos astronómicos, têm crescido em tamanho e complexidade, chegando a milhares de milhões de itens por base de dados. Os investigadores precisam de ferramentas novas e inovadoras para auxiliar na escolha desses itens. Este trabalho propõe o uso de Sistemas de Recomendação para auxiliar os investigadores a encontrar itens de interesse. Identificamos como um dos maiores desafios para a aplicação de sistemas de recomendação em áreas científicas a falta de conjuntos de dados padronizados e de acesso aberto com informações sobre as preferências dos utilizadores. Para superar esse desafio, desenvolvemos uma metodologia denominada LIBRETTI - Recomendação Baseada em Literatura de Itens Científicos, cujo objetivo é a criação de conjuntos de dados , relacionados com campos científicos. Estes conjuntos de dados são criados com base no principal recurso de conhecimento que a Ciência possui: a literatura científica. A metodologia LIBRETTI permitiu o desenvolvimento de novos algoritmos de recomendação específicos para vários campos científicos. Além do LIBRETTI, as principais contribuições desta tese são conjuntos de dados de recomendação padronizados nas áreas de Astronomia, Química e Saúde (relacionado com a doença COVID-19), um sistema de recomendação semântica híbrido para compostos químicos em conjuntos de dados de grande escala, uma abordagem híbrida baseada no enriquecimento sequencial (SeEn) para recomendações sequenciais, um pipeline baseado em semântica de vários campos para recomendar entidades biomédicas relacionadas com a doença COVID-19.Databases for scientific entities, such as chemical compounds, diseases and astronomical objects, are growing in size and complexity, reaching billions of items per database. Researchers need new and innovative tools for assisting the choice of these items. This work proposes the use of Recommender Systems approaches for helping researchers to find items of interest. We identified as one of the major challenges for applying RS in scientific fields the lack of standard and open-access datasets with information about the preferences of the users. To overcome this challenge, we developed a methodology called LIBRETTI - LIterature Based RecommEndaTion of scienTific Items, whose goal is to create datasets related to scientific fields. These datasets are created based on scientific literature, the major resource of knowledge that Science has. LIBRETTI methodology allowed the development and testing of new recommender algorithms specific for each field. Besides LIBRETTI, the main contributions of this thesis are standard and sequence-aware recommendation datasets in the fields of Astronomy, Chemistry, and Health (related to COVID-19 disease), a hybrid semantic recommender system for chemical compounds in large-scale datasets, a hybrid approach based on sequential enrichment (SeEn) for sequence-aware recommendations, a multi-field semantic-based pipeline for recommending biomedical entities related to COVID-19 disease