Intelligent Pattern Analysis of the Foetal Electrocardiogram

The aim of the project on which this thesis is based is to develop reliable techniques for foetal electrocardiogram (ECG) based monitoring, to reduce incidents of unnecessary medical intervention and foetal injury during labour. World-wide electronic foetal monitoring is based almost entirely on the cardiotocogram (CTG), which is a continuous display of the foetal heart rate (FHR) pattern together with the contraction of the womb. Despite the widespread use of the CTG, there is no significant improvement in foetal outcome. In the UK alone it is estimated that birth related negligence claims cost the health authorities over £400M per-annum. An expert system, known as INFANT, has recently been developed to assist CTG interpretation. However, the CTG alone does not always provide all the information required to improve the outcome of labour. The widespread use of ECG analysis has been hindered by the difficulties with poor signal quality and the difficulties in applying the specialised knowledge required for interpreting ECG patterns, in association with other events in labour, in an objective way. A fundamental investigation and development of optimal signal enhancement techniques that maximise the available information in the ECG signal, along with different techniques for detecting individual waveforms from poor quality signals, has been carried out. To automate the visual interpretation of the ECG waveform, novel techniques have been developed that allow reliable extraction of key features and hence allow a detailed ECG waveform analysis. Fuzzy logic is used to automatically classify the ECG waveform shape using these features by using knowledge that was elicited from expert sources and derived from example data. This allows the subtle changes in the ECG waveform to be automatically detected in relation to other events in labour, and thus improve the clinicians position for making an accurate diagnosis. To ensure the interpretation is based on reliable information and takes place in the proper context, a new and sensitive index for assessing the quality of the ECG has been developed. New techniques to capture, for the first time in machine form, the clinical expertise / guidelines for electronic foetal monitoring have been developed based on fuzzy logic and finite state machines, The software model provides a flexible framework to further develop and optimise rules for ECG pattern analysis. The signal enhancement, QRS detection and pattern recognition of important ECG waveform shapes have had extensive testing and results are presented. Results show that no significant loss of information is incurred as a result of the signal enhancement and feature extraction techniques

Data semantic enrichment for complex event processing over IoT Data Streams

This thesis generalizes techniques for processing IoT data streams, semantically enrich data with contextual information, as well as complex event processing in IoT applications. A case study for ECG anomaly detection and signal classification was conducted to validate the knowledge foundation

VAR-AS, sustained attention detection system in the learning environment

This dissertation presents a system for monitoring heart rate variability (HRV) by electrocardiogram (ECG) and photoplethysmography (PPG) for the detection of attention state in a learning environment. The ECG and PPG signs were acquired and processed through the development of a multi-microcontroller embedded system. When the waves of these signals are extracted, the heart rate is calculated through the time intervals between the R peaks for the electrocardiogram and between the beats for photopletismography. Finally, in order to indicate the level of attention on the part of the user, an input was added in which the volunteer marks the periods he or she considers to be most attentive. This data is associated with a millisecond resolution time stamp and sent in real time via Internet WiFi to a database in the cloud. After this data is stored, the HRV is analysed based on algorithms developed with the Matlab tool. These algorithms allow the study of cardiac variability according to time and frequency domains and how non-linear HRV measurements were also considered. Finally, a module for measuring skin conductivity was added, relating it to the analysis of the level of stress during the learning process. In order to prove the reliability of the system, several volunteers were tested in real environments according to a stipulated protocol. These records were analysed as a starting point to classify situations of greater attention of the volunteer in an educational scenario.Esta dissertação apresenta um sistema de monitorização da variabilidade da frequência cardíaca (VFC) através da Eletrocardiograma (ECG) e Fotoplestimografria (PPG) para a deteção do estado de atenção num ambiente de aprendizagem. Os signais de ECG e PPG foram adquiridos e processados através do desenvolvimento de um sistema embebido multi-microcontrolador. Ao extrair-se as ondas destes sinais, calcula-se a frequência cardíaca através dos intervalos de tempo entre os picos R para o eletrocardiograma e entre os batimentos para a fotopletismografia. Por fim, para poder indicaro nível da atenção da parte do utente adicionou-se um input em que o voluntário marca os períodos que considera estar mais atento. Estes dados são associados a uma marca temporal com resolução ma base de dados na nuvém. Após o armazenamento destes dados, analisa-se a VFC com base em algoritmos desenvolvidos com a ferramenta Matlab. Estes algoritmos permitem estudar a variabilidade cardíaca segundo os domínios do tempo, da frequência e como tambem foram consideradas medidas VFC não lineares. Por fim, adicionou-se um módulo para a medição da condutividade da pele, relacionando-a com a avaliação do nível de stress durante o processo de aprendizagem. Para comprovar a fiabilidade do sistema realizaram-se testes a diversos voluntários em ambientes reais de acordo com um protocolo estipulado. Estes registos foram analisados como ponto de partida para classificar situações de maior atenção do voluntário perante um cenário educativo

Progress Report No. 7

Progress report of the Biomedical Computer Laboratory, covering period 1 July 1970 to 30 June 1971

Intelligent Biosignal Processing in Wearable and Implantable Sensors

This reprint provides a collection of papers illustrating the state-of-the-art of smart processing of data coming from wearable, implantable or portable sensors. Each paper presents the design, databases used, methodological background, obtained results, and their interpretation for biomedical applications. Revealing examples are brain–machine interfaces for medical rehabilitation, the evaluation of sympathetic nerve activity, a novel automated diagnostic tool based on ECG data to diagnose COVID-19, machine learning-based hypertension risk assessment by means of photoplethysmography and electrocardiography signals, Parkinsonian gait assessment using machine learning tools, thorough analysis of compressive sensing of ECG signals, development of a nanotechnology application for decoding vagus-nerve activity, detection of liver dysfunction using a wearable electronic nose system, prosthetic hand control using surface electromyography, epileptic seizure detection using a CNN, and premature ventricular contraction detection using deep metric learning. Thus, this reprint presents significant clinical applications as well as valuable new research issues, providing current illustrations of this new field of research by addressing the promises, challenges, and hurdles associated with the synergy of biosignal processing and AI through 16 different pertinent studies. Covering a wide range of research and application areas, this book is an excellent resource for researchers, physicians, academics, and PhD or master students working on (bio)signal and image processing, AI, biomaterials, biomechanics, and biotechnology with applications in medicine

Aerospace Medicine and Biology: A continuing bibliography with indexes, supplement 140

This bibliography lists 306 reports, articles, and other documents introduced into the NASA scientific and technical information system in March 1975