57 research outputs found

    FPGA-Based Portable Ultrasound Scanning System with Automatic Kidney Detection

    Get PDF
    Bedsides diagnosis using portable ultrasound scanning (PUS) offering comfortable diagnosis with various clinical advantages, in general, ultrasound scanners suffer from a poor signal-to-noise ratio, and physicians who operate the device at point-of-care may not be adequately trained to perform high level diagnosis. Such scenarios can be eradicated by incorporating ambient intelligence in PUS. In this paper, we propose an architecture for a PUS system, whose abilities include automated kidney detection in real time. Automated kidney detection is performed by training the Viola–Jones algorithm with a good set of kidney data consisting of diversified shapes and sizes. It is observed that the kidney detection algorithm delivers very good performance in terms of detection accuracy. The proposed PUS with kidney detection algorithm is implemented on a single Xilinx Kintex-7 FPGA, integrated with a Raspberry Pi ARM processor running at 900 MHz

    Design, analysis and evaluation of sigma-delta based beamformers for medical ultrasound imaging applications

    Get PDF
    The inherent analogue nature of medical ultrasound signals in conjunction with the abundant merits provided by digital image acquisition, together with the increasing use of relatively simple front-end circuitries, have created considerable demand for single-bit beamformers in digital ultrasound imaging systems. Furthermore, the increasing need to design lightweight ultrasound systems with low power consumption and low noise, provide ample justification for development and innovation in the use of single-bit beamformers in ultrasound imaging systems. The overall aim of this research program is to investigate, establish, develop and confirm through a combination of theoretical analysis and detailed simulations, that utilize raw phantom data sets, suitable techniques for the design of simple-to-implement hardware efficient digital ultrasound beamformers to address the requirements for 3D scanners with large channel counts, as well as portable and lightweight ultrasound scanners for point-of-care applications and intravascular imaging systems. In addition, the stability boundaries of higher-order High-Pass (HP) and Band-Pass (BP) Σ−Δ modulators for single- and dual- sinusoidal inputs are determined using quasi-linear modeling together with the describing-function method, to more accurately model the modulator quantizer. The theoretical results are shown to be in good agreement with the simulation results for a variety of input amplitudes, bandwidths, and modulator orders. The proposed mathematical models of the quantizer will immensely help speed up the design of higher order HP and BP Σ−Δ modulators to be applicable for digital ultrasound beamformers. Finally, a user friendly design and performance evaluation tool for LP, BP and HP modulators is developed. This toolbox, which uses various design methodologies and covers an assortment of modulators topologies, is intended to accelerate the design process and evaluation of modulators. This design tool is further developed to enable the design, analysis and evaluation of beamformer structures including the noise analyses of the final B-scan images. Thus, this tool will allow researchers and practitioners to design and verify different reconstruction filters and analyze the results directly on the B-scan ultrasound images thereby saving considerable time and effort

    Utilization Of A Large-Scale Wireless Sensor Network For Intrusion Detection And Border Surveillance

    Get PDF
    To control the border more effectively, countries may deploy a detection system that enables real-time surveillance of border integrity. Events such as border crossings need to be monitored in real time so that any border entries can be noted by border security forces and destinations marked for apprehension. Wireless Sensor Networks (WSNs) are promising for border security surveillance because they enable enforcement teams to monitor events in the physical environment. In this work, probabilistic models have been presented to investigate senor development schemes while considering the environmental factors that affect the sensor performance. Simulation studies have been carried out using the OPNET to verify the theoretical analysis and to find an optimal node deployment scheme that is robust and efficient by incorporating geographical coordination in the design. Measures such as adding camera and range-extended antenna to each node have been investigated to improve the system performance. A prototype WSN based surveillance system has been developed to verify the proposed approach

    Multimodal Multispectral Optical Endoscopic Imaging for Biomedical Applications

    No full text
    Optical imaging is an emerging field of clinical diagnostics that can address the growing medical need for early cancer detection and diagnosis. Various human cancers are amenable to better prognosis and patient survival if found and treated during early disease onset. Besides providing wide-field, macroscopic diagnostic information similar to existing clinical imaging techniques, optical imaging modalities have the added advantage of microscopic, high resolution cellular-level imaging from in vivo tissues in real time. This comprehensive imaging approach to cancer detection and the possibility of performing an ‘optical biopsy’ without tissue removal has led to growing interest in the field with numerous techniques under investigation. Three optical techniques are discussed in this thesis, namely multispectral fluorescence imaging (MFI), hyperspectral reflectance imaging (HRI) and fluorescence confocal endomicroscopy (FCE). MFI and HRI are novel endoscopic imaging-based extensions of single point detection techniques, such as laser induced fluorescence spectroscopy and diffuse reflectance spectroscopy. This results in the acquisition of spectral data in an intuitive imaging format that allows for quantitative evaluation of tissue disease states. We demonstrate MFI and HRI on fluorophores, tissue phantoms and ex vivo tissues and present the results as an RGB colour image for more intuitive assessment. This follows dimensionality reduction of the acquired spectral data with a fixed-reference isomap diagnostic algorithm to extract only the most meaningful data parameters. FCE is a probe-based point imaging technique offering confocal detection in vivo with almost histology-grade images. We perform FCE imaging on chemotherapy-treated in vitro human ovarian cancer cells, ex vivo human cancer tissues and photosensitiser-treated in vivo murine tumours to show the enhanced detection capabilities of the technique. Finally, the three modalities are applied in combination to demonstrate an optical viewfinder approach as a possible minimally-invasive imaging method for early cancer detection and diagnosis

    A High-Performance Data Acquisition System for Smart Cameras in Science

    Get PDF
    This dissertation proposes a novel smart camera platform serving as a flexible data acquisition system for scientific applications. Current technological progress offers increasing performance in the areas we consider, namely high data-throughput, data processing, and detector performance. Prevalent data acquisition solutions typically focus on one of these aspects. However, driven by science, experiments experience increasing demands in terms of data throughput, speed and flexibility. In this dissertation, we introduce a system which, in addition to being able to provide high-speed data transfer, is also capable of interpreting the incoming information at an early stage. In order to demonstrate the full potential of the smart camera platform, we focus on X-ray imaging with synchrotron light sources. X-ray imaging applications can investigate the traits of technological and biological processes over microseconds for radiography, and milliseconds for tomography applications. These applications may require different sensors, and include complex experiment operations. The new smart camera platform is part of a larger project, UFO, which introduces a new concept for X-ray imaging. On-line data assessment is used to provide a data-driven feedback and active management of both the process and data acquisition procedure. This is accomplished using a GPU platform for fast reconstruction, embedded on-camera data processing, and integrating smart camera in a high-throughput data acquisition system. The final design of the smart camera platform consists of a custom high-performance FPGA board, providing continuous data transfer, embedded image processing, and a flexible input stage. In the IMAGE beamline of ANKA, camera is integrated in the new control system, and used in real-life applications. A maximum data-throughput of up to 8 GB/s is achieved. A custom image-based algorithm is implemented in the FPGA, with stringent real-time requirements, able to increase native sensor speed up to five times while reducing the amount of transfered data. Several image sensors are used, with resolutions of up to 20 megapixels and frame rates of up to 5 kfps. The smart camera platform was also used in non-imaging applications, stemming from the flexible input stage. The proposed camera architecture enables the user to modify the current system for any kind of high data-throughput applications, and to modify and implement custom processing algorithms

    THE PHARMACOKINETICS OF METAL-BASED ENGINEERED NANOMATERIALS, FOCUSING ON THE BLOOD-BRAIN BARRIER

    Get PDF
    Metal-based engineered nanomaterials (ENMs) have potential to revolutionize diagnosis, drug delivery and manufactured products, leading to greater human ENM exposure. It is crucial to understand ENM pharmacokinetics and their association with biological barriers such as the blood-brain barrier (BBB). Physicochemical parameters such as size and surface modification of ENMs play an important role in ENM fate, including their brain association. Multifunctional ENMs showed advantages across the highly regulated BBB. There are limited reports on ENM distribution among the blood in the brain vasculature, the BBB, and brain parenchyma. In this study, ceria ENM was used to study the effect of size on its pharmacokinetics. Four sizes of ceria ENMs were studied. Five nm ceria showed a longer half-life in the blood and higher brain association compared with other sizes and 15 and 30 nm ceria had a higher blood cell association than 5 or 55 nm ceria. Because of the long circulation and high brain association of 5 nm ceria compared with other sizes, its distribution between the BBB and brain parenchyma was studied. The in situ brain perfusion technique showed 5 nm ceria (99%) on the luminal surface of the BBB rather than the brain parenchyma. For biomedical applications in the central nervous system (CNS), it is vital to develop stable and biocompatible ENMs and enhance their uptake by taking advantage of their unique properties. Cross-linked nanoassemblies entrapping iron oxide nanoparticles (CNA-IONPs) showed controlled particle size in biological conditions and less toxicity in comparison to Citrate-IONPs. CNA-IONPs considerably enhanced MRI T2 relaxivities and generated heat at mild hyperthermic temperatures (40 ~ 42°C) in the presence of alternating magnetic field (AMF). Numerous researchers showed mild whole body hyperthermia can increase BBB permeability for potential brain therapeutic application. Compared to conventional hyperthermia, AMF-induced hyperthermia increased BBB permeability with a shorter duration of hyperthermia and lower temperature, providing the potential to enhance IONP flux across the BBB with reduced toxicity. Overall, ENMs with optimized physicochemical properties can enhance their flux across the BBB into the brain with desirable pharmacokinetics, which provide great potential for diagnosis and therapy in the CNS

    Pertanika Journal of Science & Technology

    Get PDF

    Pertanika Journal of Science & Technology

    Get PDF

    An Assessment of Indoor Geolocation Systems

    Get PDF
    Currently there is a need to design, develop, and deploy autonomous and portable indoor geolocation systems to fulfil the needs of military, civilian, governmental and commercial customers where GPS and GLONASS signals are not available due to the limitations of both GPS and GLONASS signal structure designs. The goal of this dissertation is (1) to introduce geolocation systems; (2) to classify the state of the art geolocation systems; (3) to identify the issues with the state of the art indoor geolocation systems; and (4) to propose and assess four WPI indoor geolocation systems. It is assessed that the current GPS and GLONASS signal structures are inadequate to overcome two main design concerns; namely, (1) the near-far effect and (2) the multipath effect. We propose four WPI indoor geolocation systems as an alternative solution to near-far and multipath effects. The WPI indoor geolocation systems are (1) a DSSS/CDMA indoor geolocation system, (2) a DSSS/CDMA/FDMA indoor geolocation system, (3) a DSSS/OFDM/CDMA/FDMA indoor geolocation system, and (4) an OFDM/FDMA indoor geolocation system. Each system is researched, discussed, and analyzed based on its principle of operation, its transmitter, the indoor channel, and its receiver design and issues associated with obtaining an observable to achieve indoor navigation. Our assessment of these systems concludes the following. First, a DSSS/CDMA indoor geolocation system is inadequate to neither overcome the near-far effect not mitigate cross-channel interference due to the multipath. Second, a DSSS/CDMA/FDMA indoor geolocation system is a potential candidate for indoor positioning, with data rate up to 3.2 KBPS, pseudorange error, less than to 2 m and phase error less than 5 mm. Third, a DSSS/OFDM/CDMA/FDMA indoor geolocation system is a potential candidate to achieve similar or better navigation accuracy than a DSSS/CDMA indoor geolocation system and data rate up to 5 MBPS. Fourth, an OFDM/FDMA indoor geolocation system is another potential candidate with a totally different signal structure than the pervious three WPI indoor geolocation systems, but with similar pseudorange error performance

    Radiation Effects in Materials

    Get PDF
    The study of radiation effects has developed as a major field of materials science from the beginning, approximately 70 years ago. Its rapid development has been driven by two strong influences. The properties of the crystal defects and the materials containing them may then be studied. The types of radiation that can alter structural materials consist of neutrons, ions, electrons, gamma rays or other electromagnetic waves with different wavelengths. All of these forms of radiation have the capability to displace atoms/molecules from their lattice sites, which is the fundamental process that drives the changes in all materials. The effect of irradiation on materials is fixed in the initial event in which an energetic projectile strikes a target. The book is distributed in four sections: Ionic Materials; Biomaterials; Polymeric Materials and Metallic Materials
    corecore