Gekend Talent

Rede, in verkorte vorm uitgesproken ter gelegenheid van het aanvaarden van het ambt van bijzonder hoogleraar met als leeropdracht Experimentele endocrinologie en medisch onderwijs aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam op 11 mei 2009

Van Docter Bernardo naar Endocriene Weesaandoeningen

Rede, uitgesproken ter gelegenheid van het aanvaarden van het ambt van bijzonder hoogleraar met als leeropdracht Endocriene oncologie aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam op 24 november 201

Cortisol van kop tot teen: over ‘goed en kwaad’ van een stresshormoon

Oratie uitgesproken door Prof.dr. O.C. Meijer bij de aanvaarding van het ambt van hoogleraar in de Moleculaire Neuro-endocrinologie van Corticosteroïden aan de Universiteit Leiden op maandag 12 september 2016Oratie uitgesproken door Prof.dr. O.C. Meijer bij de aanvaarding van het ambt van hoogleraar in de Moleculaire Neuro-endocrinologie van Corticosteroïden aan de Universiteit Leiden op maandag 12 september 201

Lipid peroxidation in the serum of hypothyroid patients (In Gorgan-South East of Caspian Sea)

This study was designed to determine if lipid peroxidation can be modified by hypothyroidism. Twenty eight subjects with hypothyroidism and 33 euthyroid subjects participated in this study (2007). Blood samples were collected and serum malondialdehyde, T3, T4 and TSH were measured. An increase in lipid peroxidation (expressed as Malondialdehyde, MDA) and TSH levels and also a decrease in T4 level were observed in the hypothyroid patients when compared with control groups (p<0.001). The level of T3 was not changed when compared with control groups. The results shows that hypothyroidism may not modulate the free-radical-induced oxidative damage and that hypothyroidism may not present some protection against lipid peroxidation. Thus, the enhancedlipid peroxidation may play a role in the free-radical-induced oxidative damage of some tissues in hypothyroidism. These may show that there is an important relation between hypothyroidism and lipid peroxidation. © 2008 Academic Journals Inc

Une déshydratation révélant un déficit en 3ßéta Hydroxystéroïde Déshydrogénase: à propos d’un cas

Le deficit en 3seta Hydroxysteroide Deshydrogenase (3β HSD) est un desordre autosomique recessif rare touchant les voies de synthese de tousles steroides actifs dans les surrenales et les gonades. Cliniquement, il inclut, a des degres variables, un syndrome de perte de sel et une  hypomasculination des garcons. Ces dernieres annees, plusieurs avancees en matiere de dosages hormonaux et de genetique ont ete realisees ce qui a permis de comprendre les bases moleculaires et le phenotype hormonal de ces patients. Nous exposons a travers un cas clinique les difficultes  diagnostiques de ce deficit ainsi que la prise en charge therapeutiques

Retrosternal goiters

Clinica 1 Chirurgie, Clinica de Endocrinologie, Spitalul „Sf.Spiridon”, UMF ”Gr.T.Popa”, Iaşi, România, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Introducere: Noțiunea de guşă retrosternală sau substernală reprezintă coborîrea a mai mult de 50% de glanda tiroidă în cavitatea toracică. Material şi metode: A fost efectuat un studiu retrospectiv a cazurilor de guşă retrosternală sau substernală din totalul de 2482 pacienți ce au suportat tiroidectomie în Clinica 1 Chirurgie din Iaşi în perioada 2000-2010. Guşa retrosternală a fost depistată la 54 (2,17%) pacienți. Toți bolnavii au fost îndreptați la operație din Clinica de Endocrinologie. Rezultate: Vîrsta medie a pacienților la momentul instalării diagnosticului a constituit 55,3±3,58 ani, majoritatea fiind femei – 83,3%. În manifestările clinice ale guşei retrosternale au dominat fenomenele de compresie. Dereglările funcției glandei tiroide au fost determinate prin teste hormonale efectuate în Clinica de Endocrinologie în 15 (27,7%) cazuri. Diagnoza de guşă retrosternală a fost suspectată în baza examenului clinic şi confirmată imagistic: radiografie toracică, ultrasonografie, computer tomografie. Abordul cervical a fost utilizat cu siguranță, sternotomia fiind necesară doar în 8 (14,8%) cazuri. Morbiditatea postoperatorie a constituit 5,5% (3 cazuri) cu mortalitate nulă. Durata medie de spitalizare a fost 4,3 zile. Noi am comparat datele noastre recente cu raportul privind tratamentul guşei retrosternale şi toracice în Clinica 1 Chirurgie din Iaşi în perioada anilor 1950-1979, publicat în revista „Chirurgia” în 1981. Concluzii: Guşa retrosternală reprezintă o formă specifică de patologie a glandei tiroide cu o incidență scăzută. Diagnosticul şi tratamentul guşei retrosternale implică o abordare multidisciplinară. Medicul endocrinolog are un rol important în diagnosticul şi supravegherea postoperatorie. Deşi intervenția chirurgicală este o metoda curativă de elecție pentru guşa substernală, persistă controverse privind abordul chirurgical şi rata complicațiilor. Abordul cervical poate fi utilizat cu siguranță aproape în toate cazurile, sternotomia fiind efectuată fără ezitare în caz de necesitate.Introduction: The term of retrosternal or substernal goiter means that more than 50% of thyroid gland descends in the thorax. Material and methods: There is a retrospective study on retrosternal and substernal goiter and its pathological features among 2482 patients who underwent thyroidectomy between 2000 and 2010 in the First Surgery Clinic of Iasi. Retrosternal goiter was diagnosed in 54 (2.17%) patients. All patients were referred to surgery from the Clinic of Endocrinology. Results: Mean age at diagnosis was 55.3±3.58 years, and most cases were found in women – 83.3%). The clinical picture of retrosternal goiter was dominated by compressive disorders. Thyroid function abnormalities were identified by hormonal assays performed on Endocrinology Clinic Iasi in 15 (27.7%) cases. The diagnosis of retrosternal goiter was suggested by clinical examination and confirmed by imaging: chest X-ray, ultrasound, CT scan. The cervical approach was safely performed. Only in 8 cases (14.8%), sternotomy was necessary. There was no mortality, and morbidity was 5.5% (3 cases). The length of stay in the hospital was 4.3 days. We compared our recent data with a previous report on retrosternal and thoracic goiter treated in First Surgery Clinic of Iasi during 1950 to 1979 and published in the journal “Chirurgia” in 1981. Conclusions: Retrosternal goiter is a particular form of thyroid surgical pathology presented with reduced incidence. Diagnosis and treatment of retrosternal goiter involve a multidisciplinary team. The endocrinologist has an important role in diagnosis and postoperative follow-up. Surgery is the treatment of choice for substernal goiters, but there are still some controversies on surgical approach, and complication rate. The cervical approach can be safely performed in almost all cases but when required, sternotomy should be performed without hesitation

Anticonceptie bij vogels

Nowadays, contraceptives for birds are more en more used for the prevention of reproduction and for therapeutic reasons. In female animals, the indications for the use of contraceptives are abundant or chronic egglaying, eggbinding, dystocia, salpingitis, impaction of the salpinx, prolapse of the cloaca or salpinx, rupture of the salpinx, ovarian neoplasia or ovarian cysts. In male animals contraceptives are administered to obtain teaser males, to prevent reproduction, to treat testicular neoplasia and to improve the carcass quality of poultry. For several years researchers have been studying these diseases, their treatment and prevention. This review includes the hormonal therapies as well as the surgical and endoscopic contraceptive techniques. Furthermore, the reproductive anatomy and endocrinology of birds are described. In bird practices, the administration of chemical contraceptives as well as the performance of surgical techniques and endoscopies are on the increase. Since specialization is increasing rapidly in small animal practices, it can be expected that these procedures will become more frequent in the future.Anticonceptiemiddelen worden bij vogels steeds vaker gebruikt, zowel om voortplanting te voorkomen als voor therapeutische doeleinden. De indicaties om anticonceptie toe te passen bij vrouwelijke dieren zijn het overmatig leggen van eieren, legnood, dystocie, salpingitis, eileiderimpactie, cloaca- of eileiderprolaps, eileiderruptuur, ovariële neoplasieën en -cysten. Bij mannelijke dieren worden anticonceptiemiddelen toegepast om teasermannetjes te verkrijgen, de reproductie af te remmen, testistumoren te behandelen en de karkaskwaliteit van industriëel pluimvee te verbeteren. Reeds jarenlang worden deze aandoeningen evenals de behandeling en preventie ervan onderzocht. In dit overzichtsartikel worden de hormonale, chirurgische en laparoscopische anticonceptietechnieken beschreven die gebruikt worden bij vogels. Verder worden ook de anatomie van het voortplantingsstelsel en de endocrinologie ervan beschreven. Niettegenstaande chemische castratie bij vogels steeds vaker wordt toegepast, zijn ook de chirurgische en laparoscopische technieken aan een sterke opmars bezig. Gezien de stijgende specialisatie in de kleine huisdierenpraktijk wordt verwacht dat deze ingrepen in de toekomst steeds frequenter zullen worden uitgevoerd

Syndrome d’Allgrove découvert sur une anémie ferriprive chez un enfant de 3 ans

Nous rapportons l'observation d'un enfant de 03 ans, qui s'est présenté en consultation pour une anémie   hypochrome microcytaire ferriprive traînante 18 mois auparavant, et qui a été mis sous traitement   symptomatique (fer) mal suivi en ambulatoire. Au cours de l'examen clinique, nous avons découvert une  pigmentation péri buccale, de la face dorsale des mains, des plis de flexion palmaires, des organes  génitaux  externes, des pieds, ainsi que des macules pigmentées au niveau des deux jambes, apparue 6 mois  auparavant et passée inaperçue. Devant ce tableau clinique, un bilan biologique a montré des hypoglycémies,  un taux de Cortisol de 8 heures du matin effondré, un taux de Rénine bas, un taux d'ACTH élevé, un test au  Synacthène® négatif, ce qui nous a permis d'évoquer une insuffisance surrénalienne. Un bilan étiologique a été réalisé dont un bilan immunologique avec un dosage de la 17 hydroxy-progestérone, des anticorps anti 21   hydroxylase, des anticorps anti-thyroglobuline et des acides gras à très longues chaines, et qui est revenu normal. Le bilan infectieux et radiologique a été normal. Une alacrymie a été suspectée et alors confirmée par un test de Schirmer positif, ce qui rentre dans le cadre d'une forme incomplète du syndrome d'Allgrove ou  syndrome des 3A fait habituellement d'anémie, d'insuffisance surrénalienne et d'achalasie (inconstante).Key words: anémie, Insuffisance surrénale, alacrymie, Syndrome d´Allgrove, mélanodermie, hypoglycémi