14,068 research outputs found
Multiscale Discriminant Saliency for Visual Attention
The bottom-up saliency, an early stage of humans' visual attention, can be
considered as a binary classification problem between center and surround
classes. Discriminant power of features for the classification is measured as
mutual information between features and two classes distribution. The estimated
discrepancy of two feature classes very much depends on considered scale
levels; then, multi-scale structure and discriminant power are integrated by
employing discrete wavelet features and Hidden markov tree (HMT). With wavelet
coefficients and Hidden Markov Tree parameters, quad-tree like label structures
are constructed and utilized in maximum a posterior probability (MAP) of hidden
class variables at corresponding dyadic sub-squares. Then, saliency value for
each dyadic square at each scale level is computed with discriminant power
principle and the MAP. Finally, across multiple scales is integrated the final
saliency map by an information maximization rule. Both standard quantitative
tools such as NSS, LCC, AUC and qualitative assessments are used for evaluating
the proposed multiscale discriminant saliency method (MDIS) against the
well-know information-based saliency method AIM on its Bruce Database wity
eye-tracking data. Simulation results are presented and analyzed to verify the
validity of MDIS as well as point out its disadvantages for further research
direction.Comment: 16 pages, ICCSA 2013 - BIOCA sessio
Active learning for feasible region discovery
Often in the design process of an engineer, the design specifications of the system are not completely known initially. However, usually there are some physical constraints which are already known, corresponding to a region of interest in the design space that is called feasible. These constraints often have no analytical form but need to be characterised based on expensive simulations or measurements. Therefore, it is important that the feasible region can be modeled sufficiently accurate using only a limited amount of samples. This can be solved by using active learning techniques that minimize the amount of samples w.r.t. what we try to model. Most active learning strategies focus on classification models or regression models with classification accuracy and regression accuracy in mind respectively. In this work, regression models of the constraints are used, but only the (in) feasibility is of interest. To tackle this problem, an information-theoretic sampling strategy is constructed to discover these regions. The proposed method is then tested on two synthetic examples and one engineering example and proves to outperform the current state-of-the-art
RNA secondary structure prediction from multi-aligned sequences
It has been well accepted that the RNA secondary structures of most
functional non-coding RNAs (ncRNAs) are closely related to their functions and
are conserved during evolution. Hence, prediction of conserved secondary
structures from evolutionarily related sequences is one important task in RNA
bioinformatics; the methods are useful not only to further functional analyses
of ncRNAs but also to improve the accuracy of secondary structure predictions
and to find novel functional RNAs from the genome. In this review, I focus on
common secondary structure prediction from a given aligned RNA sequence, in
which one secondary structure whose length is equal to that of the input
alignment is predicted. I systematically review and classify existing tools and
algorithms for the problem, by utilizing the information employed in the tools
and by adopting a unified viewpoint based on maximum expected gain (MEG)
estimators. I believe that this classification will allow a deeper
understanding of each tool and provide users with useful information for
selecting tools for common secondary structure predictions.Comment: A preprint of an invited review manuscript that will be published in
a chapter of the book `Methods in Molecular Biology'. Note that this version
of the manuscript may differ from the published versio
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