Techniques for clustering gene expression data

Many clustering techniques have been proposed for the analysis of gene expression data obtained from microarray experiments. However, choice of suitable method(s) for a given experimental dataset is not straightforward. Common approaches do not translate well and fail to take account of the data profile. This review paper surveys state of the art applications which recognises these limitations and implements procedures to overcome them. It provides a framework for the evaluation of clustering in gene expression analyses. The nature of microarray data is discussed briefly. Selected examples are presented for the clustering methods considered

Factor Analysis vs. Fuzzy Sets Theory: Assessing the Influence of Different Techniques on Sen's Functioning Approach

This paper explores a couple of specific operational interpretations of Sen's approach in view of assessing the extent to which the results originated by the implementation of Sen's concepts are influenced by the choice of the specific technique. By means of a survey based on a representative sample of Belgian individuals, seven achieved functioning's are identified via each technique and subsequently confronted. To structure the information and to facilitate comparisons, standard multivariate analysis is performed, while at the same time considering in more detail the sub-group of the most deprived individuals. In this way, a substantial accordance - yet no perfect equivalence - is uncovered in the general patterns of functionings' achievements.

Factor Analysis vs Fuzzy Sets Theory: Assessing the Influence of Different Techniques on Sen's Functioning Approach.

This paper explores a couple of specific operational interpretations of Sen's approach in view of assessing the extent to which the results originated by the implementation of Sen's concepts are influenced by the choice of the specific technique. By means of a survey based on a representative sample of Belgian individuals, seven achieved functioning's are identified via each technique and subsequently confronted. To structure the information and to facilitate comparisons, standard multivariate analysis is performed, while at the same time considering in more detail the sub-group of the most deprived individuals. In this way, a substantial accordance - yet no perfect equivalence - is uncovered in the general patterns of functioning's' achievements.

Bayesian recursive parameter estimation for hydrologic models

The uncertainty in a given hydrologic prediction is the compound effect of the parameter, data, and structural uncertainties associated with the underlying model. In general, therefore, the confidence in a hydrologic prediction can be improved by reducing the uncertainty associated with the parameter estimates. However, the classical approach to doing this via model calibration typically requires that considerable amounts of data be collected and assimilated before the model can be used. This limitation becomes immediately apparent when hydrologic predictions must be generated for a previously ungauged watershed that has only recently been instrumented. This paper presents the framework for a Bayesian recursive estimation approach to hydrologic prediction that can be used for simultaneous parameter estimation and prediction in an operational setting. The prediction is described in terms of the probabilities associated with different output values. The uncertainty associated with the parameter estimates is updated (reduced) recursively, resulting in smaller prediction uncertainties as measurement data are successively assimilated. The effectiveness and efficiency of the method are illustrated in the context of two models: a simple unit hydrograph model and the more complex Sacramento soil moisture accounting model, using data from the Leaf River basin in Mississippi

Analytic Expressions for Stochastic Distances Between Relaxed Complex Wishart Distributions

The scaled complex Wishart distribution is a widely used model for multilook full polarimetric SAR data whose adequacy has been attested in the literature. Classification, segmentation, and image analysis techniques which depend on this model have been devised, and many of them employ some type of dissimilarity measure. In this paper we derive analytic expressions for four stochastic distances between relaxed scaled complex Wishart distributions in their most general form and in important particular cases. Using these distances, inequalities are obtained which lead to new ways of deriving the Bartlett and revised Wishart distances. The expressiveness of the four analytic distances is assessed with respect to the variation of parameters. Such distances are then used for deriving new tests statistics, which are proved to have asymptotic chi-square distribution. Adopting the test size as a comparison criterion, a sensitivity study is performed by means of Monte Carlo experiments suggesting that the Bhattacharyya statistic outperforms all the others. The power of the tests is also assessed. Applications to actual data illustrate the discrimination and homogeneity identification capabilities of these distances.Comment: Accepted for publication in the IEEE Transactions on Geoscience and Remote Sensing journa

The safety case and the lessons learned for the reliability and maintainability case

This paper examine the safety case and the lessons learned for the reliability and maintainability case

European exchange trading funds trading with locally weighted support vector regression

In this paper, two different Locally Weighted Support Vector Regression (wSVR) algorithms are generated and applied to the task of forecasting and trading five European Exchange Traded Funds. The trading application covers the recent European Monetary Union debt crisis. The performance of the proposed models is benchmarked against traditional Support Vector Regression (SVR) models. The Radial Basis Function, the Wavelet and the Mahalanobis kernel are explored and tested as SVR kernels. Finally, a novel statistical SVR input selection procedure is introduced based on a principal component analysis and the Hansen, Lunde, and Nason (2011) model confidence test. The results demonstrate the superiority of the wSVR models over the traditional SVRs and of the v-SVR over the ε-SVR algorithms. We note that the performance of all models varies and considerably deteriorates in the peak of the debt crisis. In terms of the kernels, our results do not confirm the belief that the Radial Basis Function is the optimum choice for financial series

A survey on utilization of data mining approaches for dermatological (skin) diseases prediction

Due to recent technology advances, large volumes of medical data is obtained. These data contain valuable information. Therefore data mining techniques can be used to extract useful patterns. This paper is intended to introduce data mining and its various techniques and a survey of the available literature on medical data mining. We emphasize mainly on the application of data mining on skin diseases. A categorization has been provided based on the different data mining techniques. The utility of the various data mining methodologies is highlighted. Generally association mining is suitable for extracting rules. It has been used especially in cancer diagnosis. Classification is a robust method in medical mining. In this paper, we have summarized the different uses of classification in dermatology. It is one of the most important methods for diagnosis of erythemato-squamous diseases. There are different methods like Neural Networks, Genetic Algorithms and fuzzy classifiaction in this topic. Clustering is a useful method in medical images mining. The purpose of clustering techniques is to find a structure for the given data by finding similarities between data according to data characteristics. Clustering has some applications in dermatology. Besides introducing different mining methods, we have investigated some challenges which exist in mining skin data