A multiplex connectivity map of valence-arousal emotional model

high number of studies have already demonstrated an electroencephalography (EEG)-based emotion recognition system with moderate results. Emotions are classified into discrete and dimensional models. We focused on the latter that incorporates valence and arousal dimensions. The mainstream methodology is the extraction of univariate measures derived from EEG activity from various frequencies classifying trials into low/high valence and arousal levels. Here, we evaluated brain connectivity within and between brain frequencies under the multiplexity framework. We analyzed an EEG database called DEAP that contains EEG responses to video stimuli and users’ emotional self-assessments. We adopted a dynamic functional connectivity analysis under the notion of our dominant coupling model (DoCM). DoCM detects the dominant coupling mode per pair of EEG sensors, which can be either within frequencies coupling (intra) or between frequencies coupling (cross-frequency). DoCM revealed an integrated dynamic functional connectivity graph (IDFCG) that keeps both the strength and the preferred dominant coupling mode. We aimed to create a connectomic mapping of valence-arousal map via employing features derive from IDFCG. Our results outperformed previous findings succeeding to predict in a high accuracy participants’ ratings in valence and arousal dimensions based on a flexibility index of dominant coupling modes

Topological changes of brain network during mindfulness meditation: an exploratory source level magnetoencephalographic study

We have previously evidenced that Mindfulness Meditation (MM) in experienced meditators (EMs) is associated with long-lasting topological changes in resting state condition. However, what occurs during the meditative phase is still debated. Utilizing magnetoencephalography (MEG), the present study is aimed at comparing the topological features of the brain network in a group of EMs (n = 26) during the meditative phase with those of individuals who had no previous experience of any type of meditation (NM group, n = 29). A wide range of topological changes in the EM group as compared to the NM group has been shown. Specifically, in EMs, we have observed increased betweenness centrality in delta, alpha, and beta bands in both cortical (left medial orbital cortex, left postcentral area, and right visual primary cortex) and subcortical (left caudate nucleus and thalamus) areas. Furthermore, the degree of beta band in parietal and occipital areas of EMs was increased too. Our exploratory study suggests that the MM can change the functional brain network and provides an explanatory hypothesis on the brain circuits characterizing the meditative process

Developing multidimensional metrics for evaluating paediatric neurodevelopmental disorders

Healthy brain functioning depends on efficient communication of information between brain regions, forming complex networks. By quantifying synchronisation between brain regions, a functionally connected brain network can be articulated. In neurodevelopmental disorders, where diagnosis is based on measures of behaviour and tasks, a measure of the underlying biological mechanisms holds promise as a potential clinical tool. Graph theory provides a tool for investigating the neural correlates of neuropsychiatric disorders, where there is disruption of efficient communication within and between brain networks. This research aimed to use recent conceptualisation of graph theory, along with measures of behaviour and cognitive functioning, to increase understanding of the neurobiological risk factors of atypical development. Using magnetoencephalography to investigate frequency-specific temporal dynamics at rest, the research aimed to identify potential biological markers derived from sensor-level whole-brain functional connectivity. Whilst graph theory has proved valuable for insight into network efficiency, its application is hampered by two limitations. First, its measures have hardly been validated in MEG studies, and second, graph measures have been shown to depend on methodological assumptions that restrict direct network comparisons. The first experimental study (Chapter 3) addressed the first limitation by examining the reproducibility of graph-based functional connectivity and network parameters in healthy adult volunteers. Subsequent chapters addressed the second limitation through adapted minimum spanning tree (a network analysis approach that allows for unbiased group comparisons) along with graph network tools that had been shown in Chapter 3 to be highly reproducible. Network topologies were modelled in healthy development (Chapter 4), and atypical neurodevelopment (Chapters 5 and 6). The results provided support to the proposition that measures of network organisation, derived from sensor-space MEG data, offer insights helping to unravel the biological basis of typical brain maturation and neurodevelopmental conditions, with the possibility of future clinical utility

Language impairments and resting-state EEG in brain tumour patients:Revealing connections

Intact language functions are crucial for everyday communication. A brain tumour can impair these functions. We studied language abilities and their relation to resting-state brain activity in low-grade brain tumour patients, in search for predictors of language outcome after surgery. The brain tumours in this thesis include gliomas, which originate in the brain, and meningiomas, which arise from the meninges. Glioma and meningioma patients underwent thorough language assessments and brain activity registrations by electroencephalography (EEG). Two aspects of brain activity were evaluated: slow-wave activity, concerning activity with a low frequency, and functional connectivity brain networks, reflecting the extent to which brain areas interact.It is concluded that low-grade gliomas can cause impairments in a variety of language abilities. Furthermore, meningiomas can induce language impairments (primarily in speech production and writing), despite that these tumours do not infiltrate brain tissue. Many glioma and meningioma patients are presented with language impairments 1 year after surgery, but there is large interpatient variation. Our findings underline the importance of extensive language testing before and after brain tumour surgery. With regard to the EEG analyses, the outcomes indicate that increased slow-wave activity and particular characteristics of the functional connectivity networks are associated with poorer language functioning before surgery in glioma patients, unlike in meningioma patients. Moreover, two predictors of language outcome after glioma surgery are identified. This line of research requires further investigation because it has the potential to improve clinical procedures, such as treatment planning, patient counselling, and language rehabilitation

Functional connectivity analysis of cerebellum using spatially constrained spectral clustering

The human cerebellum contains almost 50% of the neurons in the brain, although its volume does not exceed 10% of the total brain volume. The goal of this study is to derive the functional network of the cerebellum during the resting-state and then compare the ensuing group networks between males and females. Toward this direction, a spatially constrained version of the classic spectral clustering algorithm is proposed and then compared against conventional spectral graph theory approaches, such as spectral clustering, and N-cut, on synthetic data as well as on resting-state fMRI data obtained from the Human Connectome Project (HCP). The extracted atlas was combined with the anatomical atlas of the cerebellum resulting in a functional atlas with 46 regions of interest. As a final step, a gender-based network analysis of the cerebellum was performed using the data-driven atlas along with the concept of the minimum spanning trees. The simulation analysis results confirm the dominance of the spatially constrained spectral clustering approach in discriminating activation patterns under noisy conditions. The network analysis results reveal statistically significant differences in the optimal tree organization between males and females. In addition, the dominance of the left VI lobule in both genders supports the results reported in a previous study of ours. To our knowledge, the extracted atlas comprises the first resting-state atlas of the cerebellum based on HCP data

EEG-induced Fear-type Emotion Classification Through Wavelet Packet Decomposition, Wavelet Entropy, and SVM

Among the most significant characteristics of human beings is their ability to feel emotions. In recent years, human-machine interface (HM) research has centered on ways to empower the classification of emotions. Mainly, human-computer interaction (HCI) research concentrates on methods that enable computers to reveal the emotional states of humans. In this research, an emotion detection system based on visual IAPPS pictures through EMOTIV EPOC EEG signals was proposed. We employed EEG signals acquired from channels (AF3, F7, F3, FC5, T7, P7, O1, O2, P8, T8, FC6, F4, F8, AF4) for individuals in a visual induced setting (IAPS fear and neutral aroused pictures). The wavelet packet transform (WPT) combined with the wavelet entropy algorithm was applied to the EEG signals. The entropy values were extracted for every two classes. Finally, these feature matrices were fed into the SVM (Support Vector Machine) type classifier to generate the classification model. Also, we evaluated the proposed algorithm as area under the ROC (Receiver Operating Characteristic) curve, or simply AUC (Area under the curve) was utilized as an alternative single-number measure. Overall classification accuracy was obtained at 91.0%. For classification, the AUC value given for SVM was 0.97. The calculations confirmed that the proposed approaches are successful for the detection of the emotion of fear stimuli via EMOTIV EPOC EEG signals and that the accuracy of the classification is acceptable