Transcranial direct current stimulation over multiple days improves learning and maintenance of a novel vocabulary

Introduction: Recently, growing interest emerged in the enhancement of human potential by means of non-invasive brain stimulation. In particular, anodal transcranial direct current stimulation (atDCS) has been shown to exert beneficial effects on motor and higher cognitive functions. However, the majority of transcranial direct current stimulation (tDCS) studies have assessed effects of single stimulation sessions that are mediated by transient neural modulation. Studies assessing the impact of multiple stimulation sessions on learning that may induce long-lasting behavioural and neural changes are scarce and have not yet been accomplished in the language domain in healthy individuals

The Effects of Anodal Stimulation of the Left Prefrontal Cortex on Sentence Production

Most studies in which Anodal Transcranial Direct Current Stimulation (A-tDCS) has been used to improve language production have focused on single words. Yet sentence production requires more than lexical retrieval. For example, successful suppression of the past and careful planning of the future are two critical requirements for producing a correct sentence. Can A-tDCS improves those, and by extension, production at the sentence level

Lernen aus neurowissenschaftlicher Sicht: von der Assoziation zur Kognition

"Lernen findet über die gesamte Lebensspanne hinweg statt. Die meisten alltäglichen Lernprozesse (wie Erwerb motorischer Bewegungsabfolgen, Faktenwissen und sozialer Konventionen) erfolgen 'automatisiert' und werden hier unter dem Begriff 'assoziatives Lernen' zusammengefasst. Der folgende Beitrag gibt zunächst einen Überblick über die neurowissenschaftlichen Grundlagen assoziativen Lernens. Im Anschluss wird beispielhaft am Spracherwerb dargestellt, wie neues Wissen erfolgreich über assoziatives Lernen vermittelt werden kann. Drittens wird eine non-pharmakologische Möglichkeit der Verstärkung assoziativen Lernens durch körperliche Voraktivierung vorgestellt. Abschließend wird auf die Anwendungsmöglichkeiten dieser Lernprinzipien im Schulalltag eingegangen." (Autorenreferat)"Learning takes place at all stages of life. The majority of daily learning processes, like learning new motor sequences or the acquisition of facts and social conventions, occur automatically and are summarized here under the term 'associative learning'. The following article first gives an overview of the neuroscientific basis for associative learning. Taking language acquisition as an example, the successful acquisition of a new mini-vocabulary by associative learning principles is then demonstrated. A third section presents a non-pharmacological strategy to promote associative learning by motor coactivation. Finally, the application of associative learning principles in educational settings is described." (author's abstract

Factors influencing reading difficulties of advanced learners of English as a Foreign Language when reading authentic texts

A thesis submitted to the University of Luton in partial fulfilment of the requirements for the degree of Doctor of PhilosophyThis thesis investigates factors influencing the reading difficulties of advanced learners of English as a foreign language. It proposes a new approach to reading research and pedagogy in which neuroscientific insights on human verbal and non-verbal cognition are incorporated into the theoretical conceptualisation. This thesis explores the neurosdentific literature for the purpose of identifying basic principles governing human perception, emotion and cognition. The mechanisms of learning and memory are also studied. It examines how the verbal systems of the brain interact with the non-verbal systems. Making use of neural perspectives, a critical review of historical and of current reading models is conducted. Attempts are made to provide alternative interpretations for the phenomena recognised in empirical studies based on observations of reading behaviours, on computer-based studies and on the introspective data of experts and of learners. This thesis reports two experiments which were designed to investigate the Ll and L2 reading processes through Think Aloud, Immediate Retrospection, Questionnaires and Interviews. The results indicate that advanced learners, despite their established reading ability in their native languages, often rely heavily on cognitive and studial styles of L2 reading which inhibit fluent and effective reading. Neural accounts are offered which suggest that the ineffective reading styles are due to weakness in the degree of neural developments. This thesis evaluates the reading sections of current and typical coursebooks according to neural-based criteria and concludes that learners are not being given the opportunities to develop the neural networks required in fluent and enjoyable reading. Finally suggestions are made for future reading research and pedagogy

Artificial grammar learning in primates :behaviour and neuroimaging

PhD ThesisNeuroimaging studies have shown that natural language processes engage left hemisphere perisylvian brain regions. Artificial Grammars (AG), which are designed to emulate aspects of language syntactic structure, recruit comparable brain areas. Nonhuman animals have been shown to learn a range of different AGs. However, no data is currently available regarding the brain areas that support these processes. In this thesis, I combined behavioural artificial grammar learning (AGL) and fMRI experiments to generate insights regarding language evolution, and as a first step to developing animal model systems for aspects of language processing. These experiments provide novel evidence that nonhuman primates are able to learn a non-deterministic AG, designed to emulate some of the variability of the structure of sentences in natural language, and demonstrated notable correspondences between the brain regions involved in macaque and human AGL. I developed a quantitative method to compare AGL abilities across species and studies, and a novel eye-tracking technique with which to collect objective behavioural data. Using this technique, and a refined version of a traditional video-coding paradigm, I demonstrated that Rhesus macaques notice violations of the AG structure and that these results could not be explained by reliance on simple cues. Common marmosets also showed evidence of AGL however, these results may have been driven by simple learning strategies. Comparative fMRI experiments showed that, in humans, violations of the AG activated a number of perisylvian brain regions associated with language processing, including the ventral frontal cortex (vFC), temporal and temporo-parietal regions, although not Broca’s area (BA44/45). In Rhesus macaques, comparable patterns of activation were seen in the ventral frontal cortex and temporo-parietal regions. Additional activation in BA44/45 in macaques provides interesting insights into the evolution of this region. These experiments provide novel evidence regarding the AGL capabilities of nonhuman primates, and the brain areas that support them, suggesting that some language related functions may represent generic, rather than language specific processes. Therefore, some of the brain regions involved in AGL in both species might share a common evolutionary heritage, and therefore Rhesus macaques might represent a valuable animal model system for aspects of language processing

Exploring the neurobiology of reading through non-invasive brain stimulation: A review

Non-invasive brain stimulation (NIBS) has gained increasing popularity as a modulatory tool for drawing causal inferences and exploring task-specific network interactions. Yet, a comprehensive synthesis of reading-related NIBS studies is still missing. We fill this gap by synthesizing the results of 78 NIBS studies investigating the causal involvement of brain regions for reading processing, and then link these results to a neurobiological model of reading. The included studies provide evidence for a functional-anatomical double dissociation for phonology versus semantics during reading-related processes within left inferior frontal and parietal areas. Additionally, the posterior parietal cortex and the anterior temporal lobe are identified as critical regions for reading-related processes. Overall, the findings provide some evidence for a dual-stream neurobiological model of reading, in which a dorsal stream (left temporo-parietal and inferior frontal areas) processes unfamiliar words and pseudowords, and a ventral stream (left occipito-temporal and inferior frontal areas, with assistance from the angular gyrus and the anterior temporal lobe) processes known words. However, individual differences in reading abilities and strategies, as well as differences in stimulation parameters, may impact the neuromodulatory effects induced by NIBS. We emphasize the need to investigate task-specific network interactions in future studies by combining NIBS with neuroimaging

Music in the brain

Music is ubiquitous across human cultures — as a source of affective and pleasurable experience, moving us both physically and emotionally — and learning to play music shapes both brain structure and brain function. Music processing in the brain — namely, the perception of melody, harmony and rhythm — has traditionally been studied as an auditory phenomenon using passive listening paradigms. However, when listening to music, we actively generate predictions about what is likely to happen next. This enactive aspect has led to a more comprehensive understanding of music processing involving brain structures implicated in action, emotion and learning. Here we review the cognitive neuroscience literature of music perception. We show that music perception, action, emotion and learning all rest on the human brain’s fundamental capacity for prediction — as formulated by the predictive coding of music model. This Review elucidates how this formulation of music perception and expertise in individuals can be extended to account for the dynamics and underlying brain mechanisms of collective music making. This in turn has important implications for human creativity as evinced by music improvisation. These recent advances shed new light on what makes music meaningful from a neuroscientific perspective