283 research outputs found
Asymptotic decay under nonlinear and noncoercive dissipative effects for electrical conduction in biological tissues
We consider a nonlinear model for electrical conduction in biological
tissues. The nonlinearity appears in the interface condition prescribed on the
cell membrane.
The purpose of this paper is proving asymptotic convergence for large times
to a periodic solution when time-periodic boundary data are assigned. The
novelty here is that we allow the nonlinearity to be noncoercive. We consider
both the homogenized and the non-homogenized version of the problem
Existence, uniqueness and concentration for a system of PDEs involving the Laplace-Beltrami operator
In this paper we derive a model for heat diffusion in a composite medium in which the different components are separated by thermally active interfaces. The previous result is obtained via a concentrated capacity procedure and leads to a non-stantard system of PDEs involving a Laplace-Beltrami operator acting on the interface. For such a system well-posedness is proved using contraction mapping and abstract parabolic problems theory. Finally, the exponential convergence (in time) of the solutions of our system to a steady state is proved
Nonlinear physics of electrical wave propagation in the heart: a review
The beating of the heart is a synchronized contraction of muscle cells
(myocytes) that are triggered by a periodic sequence of electrical waves (action
potentials) originating in the sino-atrial node and propagating over the atria and
the ventricles. Cardiac arrhythmias like atrial and ventricular fibrillation (AF,VF)
or ventricular tachycardia (VT) are caused by disruptions and instabilities of these
electrical excitations, that lead to the emergence of rotating waves (VT) and turbulent
wave patterns (AF,VF). Numerous simulation and experimental studies during the
last 20 years have addressed these topics. In this review we focus on the nonlinear
dynamics of wave propagation in the heart with an emphasis on the theory of pulses,
spirals and scroll waves and their instabilities in excitable media and their application
to cardiac modeling. After an introduction into electrophysiological models for action
potential propagation, the modeling and analysis of spatiotemporal alternans, spiral
and scroll meandering, spiral breakup and scroll wave instabilities like negative line
tension and sproing are reviewed in depth and discussed with emphasis on their impact
in cardiac arrhythmias.Peer ReviewedPreprin
Cardiac cell modelling: Observations from the heart of the cardiac physiome project
In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In particular we focus on the relationship between experimental data and model parameterisation across a range of model types and cellular physiological systems. Finally, in the context of parameter identification and model reuse within the Cardiac Physiome, we suggest some future priority areas for this field
Modeling and simulation in tribology across scales: An overview
This review summarizes recent advances in the area of tribology based on the outcome of a Lorentz Center workshop surveying various physical, chemical and mechanical phenomena across scales. Among the main themes discussed were those of rough surface representations, the breakdown of continuum theories at the nano- and micro-scales, as well as multiscale and multiphysics aspects for analytical and computational models relevant to applications spanning a variety of sectors, from automotive to biotribology and nanotechnology. Significant effort is still required to account for complementary nonlinear effects of plasticity, adhesion, friction, wear, lubrication and surface chemistry in tribological models. For each topic, we propose some research directions
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