Sam2bam: High-Performance Framework for NGS Data Preprocessing Tools

This paper introduces a high-throughput software tool framework called {\it sam2bam} that enables users to significantly speedup pre-processing for next-generation sequencing data. The sam2bam is especially efficient on single-node multi-core large-memory systems. It can reduce the runtime of data pre-processing in marking duplicate reads on a single node system by 156-186x compared with de facto standard tools. The sam2bam consists of parallel software components that can fully utilize the multiple processors, available memory, high-bandwidth of storage, and hardware compression accelerators if available. The sam2bam provides file format conversion between well-known genome file formats, from SAM to BAM, as a basic feature. Additional features such as analyzing, filtering, and converting the input data are provided by {\it plug-in} tools, e.g., duplicate marking, which can be attached to sam2bam at runtime. We demonstrated that sam2bam could significantly reduce the runtime of NGS data pre-processing from about two hours to about one minute for a whole-exome data set on a 16-core single-node system using up to 130 GB of memory. The sam2bam could reduce the runtime for whole-genome sequencing data from about 20 hours to about nine minutes on the same system using up to 711 GB of memory

Oracle SuperCluster: Taking Oracle Clustered Engineering Systems to the Next Level

Oracle's Super Cluster is robust and coherent Oracle Database and application environment. Oracle SuperCluster is an engineered and homogeneous server, with storage, consistent networking and software system which provides extreme end-to-end database, application capacity also minimal initial, ongoing assist and maintenance effort and convolution at the low total cost of possession. It is ideal for Oracle Database that is best for Oracle application customers who need to maximize return on the software investments, increase their IT agility and improve the application usability and overall IT productivity. DOI: 10.17762/ijritcc2321-8169.150610

Aerospace medicine and biology: A continuing bibliography with indexes, supplement 204

This bibliography lists 140 reports, articles, and other documents introduced into the NASA scientific and technical information system in February 1980

When Things Matter: A Data-Centric View of the Internet of Things

With the recent advances in radio-frequency identification (RFID), low-cost wireless sensor devices, and Web technologies, the Internet of Things (IoT) approach has gained momentum in connecting everyday objects to the Internet and facilitating machine-to-human and machine-to-machine communication with the physical world. While IoT offers the capability to connect and integrate both digital and physical entities, enabling a whole new class of applications and services, several significant challenges need to be addressed before these applications and services can be fully realized. A fundamental challenge centers around managing IoT data, typically produced in dynamic and volatile environments, which is not only extremely large in scale and volume, but also noisy, and continuous. This article surveys the main techniques and state-of-the-art research efforts in IoT from data-centric perspectives, including data stream processing, data storage models, complex event processing, and searching in IoT. Open research issues for IoT data management are also discussed

Doctor of Philosophy

dissertationIn the past few years, we have seen a tremendous increase in digital data being generated. By 2011, storage vendors had shipped 905 PB of purpose-built backup appliances. By 2013, the number of objects stored in Amazon S3 had reached 2 trillion. Facebook had stored 20 PB of photos by 2010. All of these require an efficient storage solution. To improve space efficiency, compression and deduplication are being widely used. Compression works by identifying repeated strings and replacing them with more compact encodings while deduplication partitions data into fixed-size or variable-size chunks and removes duplicate blocks. While we have seen great improvements in space efficiency from these two approaches, there are still some limitations. First, traditional compressors are limited in their ability to detect redundancy across a large range since they search for redundant data in a fine-grain level (string level). For deduplication, metadata embedded in an input file changes more frequently, and this introduces more unnecessary unique chunks, leading to poor deduplication. Cloud storage systems suffer from unpredictable and inefficient performance because of interference among different types of workloads. This dissertation proposes techniques to improve the effectiveness of traditional compressors and deduplication in improving space efficiency, and a new IO scheduling algorithm to improve performance predictability and efficiency for cloud storage systems. The common idea is to utilize similarity. To improve the effectiveness of compression and deduplication, similarity in content is used to transform an input file into a compression- or deduplication-friendly format. We propose Migratory Compression, a generic data transformation that identifies similar data in a coarse-grain level (block level) and then groups similar blocks together. It can be used as a preprocessing stage for any traditional compressor. We find metadata have a huge impact in reducing the benefit of deduplication. To isolate the impact from metadata, we propose to separate metadata from data. Three approaches are presented for use cases with different constrains. For the commonly used tar format, we propose Migratory Tar: a data transformation and also a new tar format that deduplicates better. We also present a case study where we use deduplication to reduce storage consumption for storing disk images, while at the same time achieving high performance in image deployment. Finally, we apply the same principle of utilizing similarity in IO scheduling to prevent interference between random and sequential workloads, leading to efficient, consistent, and predictable performance for sequential workloads and a high disk utilization

Index to 1981 NASA Tech Briefs, volume 6, numbers 1-4

Short announcements of new technology derived from the R&D activities of NASA are presented. These briefs emphasize information considered likely to be transferrable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. This index for 1981 Tech Briefs contains abstracts and four indexes: subject, personal author, originating center, and Tech Brief Number. The following areas are covered: electronic components and circuits, electronic systems, physical sciences, materials, life sciences, mechanics, machinery, fabrication technology, and mathematics and information sciences