Training Manual ICAR Short course on Application of advanced molecular methods in marine fishery resource management, conservation and sustainable mariculture

Molecular Biology and Biotechnology has undergone incredible progress in this decade mainly due to the rapid advancements in DNA sequencing technologies. Marine biology and fishery science also reaped the fruits of these modern inventions improving our understanding regarding complex adaptations in aquatic organisms. Fish Genetics have evolved into genomics incorporating knowledge about neutral and non-neutral markers. A project called Genome 10k was started by the international community of scientists for sequencing the genome of 10000 vertebrates. Whole genomes of many marine organisms are now available which provided insights into the evolution of many important traits. Transcriptome sequencing provides insights into expressed genes and metagenome sequencing provides information regarding the microbes present in environment. All these technologies are rapid and cost effective. Over years, these technologies provided exciting opportunities for understanding ecology and evolution. Genomic information can also be sustainably utilized to enhance productivity of mariculture activities by selective breeding, genetic improvement and manipulation of economically important traits. ICAR-Central Marine Fisheries Research Institute has contributed significantly to marine biotechnology research in the country and played a pivotal role in development of marine fisheries sector. The short course on “Application of advanced molecular methods in marine fisheries resource management, conservation and sustainable mariculture” conducted in ICAR-CMFRI from 24th October, 2018 to 2nd November, 2018 is specially designed to provide exposure to various applications of molecular tools in fisheries resource management, conservation of biodiversity and mariculture. I hope this compendium of lectures and protocols will be extremely useful for the participants to effectively utilize the knowledge in their own area of research. Simultaneously, on behalf of ICAR-CMFRI, I warmly welcome all the participants from various institutions and wish them all success in their future endeavors. I am sure that this training will result in new knowledge, collaborations and friendships

Developing new genomic integration-free gene and cell therapy strategies for muscular dystrophy

Duchenne muscular dystrophy (DMD) is caused by mutations on the Xlinked dystrophin gene and primarily affects skeletal muscles, resulting in disability and premature death. This thesis looks at different strategies to circumvent substantial obstacles in the development of therapies for this incurable disease. Here I hypothesise that the limited availability of large number of cells and the large size of the dystrophin gene (2.4Mb) can be tackled by combining human artificial chromosome (HAC)-based gene correction and induced pluripotent stem cell (iPSC)-mediated production of transplantable myogenic cells. However, another significant hurdle is posed by cell delivery, as skeletal muscle is the most abundant human tissue; therefore I also focused on developing a novel strategy to make the aforementioned DMD iPSC-derived myogenic population systemically deliverable. I hypothesised that cell fate modulators of native skeletal myoblasts could enhanced migratory properties also to human iPSCderived myogenic progenitors. I show that exposure to the Notch ligand DLL4 and PDGF-BB can induce the acquisition of some key properties such as a perivascular marker expression profile and an improved migration in vitro. Taken together these results lay the foundation for a small molecule-based strategy to allow systemic delivery of geneticallycorrected, genomic-integration-free, iPSC-derived myogenic cells for the autologous gene and cell therapy of DMD

Word Knowledge and Word Usage

Word storage and processing define a multi-factorial domain of scientific inquiry whose thorough investigation goes well beyond the boundaries of traditional disciplinary taxonomies, to require synergic integration of a wide range of methods, techniques and empirical and experimental findings. The present book intends to approach a few central issues concerning the organization, structure and functioning of the Mental Lexicon, by asking domain experts to look at common, central topics from complementary standpoints, and discuss the advantages of developing converging perspectives. The book will explore the connections between computational and algorithmic models of the mental lexicon, word frequency distributions and information theoretical measures of word families, statistical correlations across psycho-linguistic and cognitive evidence, principles of machine learning and integrative brain models of word storage and processing. Main goal of the book will be to map out the landscape of future research in this area, to foster the development of interdisciplinary curricula and help single-domain specialists understand and address issues and questions as they are raised in other disciplines

Training Manual In the frame work of the project: DBT sponsored Three Months National Training in Molecular Biology and Biotechnology for Fisheries Professionals 2015-18

This is a limited edition of the CMFRI Training Manual provided to participants of the “DBT sponsored Three Months National Training in Molecular Biology and Biotechnology for Fisheries Professionals” organized by the Marine Biotechnology Division of Central Marine Fisheries Research Institute (CMFRI), from 2nd February 2015 - 31st March 2018

Systematics 2008 - Programme and Abstracts

The Göttingen conference „Systematics 2008“ is the first joint meeting of the Gesellschaft für Biologische Systematik (GfBS) and the German Botanical Society, section Biodiversity and Evolutionary Biology (DBG), being the 10th Annual Meeting of the GfBS and the 18th International Symposium „Biodiversity and Evolutionary Biology“ of the DBG. The conference programme covers biological systematics in the widest sense and provides ample opportunities for oral and poster presentations on new advances in plant, animal and microbial systematics. This volume brings together the abstracts of invited speaches from the plenary sessions on „Progress in Deep Phylogeny“, „Speciation and Phylogeography“, and „New Trends in Biological Systematics“ as well as those of submitted talks and poster sessions.The Göttingen conference „Systematics 2008“ is the first joint meeting of the Gesellschaft für Biologische Systematik (GfBS) and the German Botanical Society, section Biodiversity and Evolutionary Biology (DBG), being the 10th Annual Meeting of the GfBS and the 18th International Symposium „Biodiversity and Evolutionary Biology“ of the DBG. The conference programme covers biological systematics in the widest sense and provides ample opportunities for oral and poster presentations on new advances in plant, animal and microbial systematics. This volume brings together the abstracts of invited speaches from the plenary sessions on „Progress in Deep Phylogeny“, „Speciation and Phylogeography“, and „New Trends in Biological Systematics“ as well as those of submitted talks and poster sessions

Programme and abstracts / Systematics 2008 : Göttingen 7-11 April 2008 / 10th Annual Meeting of the Gesellschaft für Biologische Systematik

The Göttingen conference Systematics 2008 is the first joint meeting of the Gesellschaft für Biologische Systematik (GfBS) and the German Botanical Society, section Biodiversity and Evolutionary Biology (DBG), being the 10th Annual Meeting of the GfBS and the 18th International Symposium Biodiversity and Evolutionary Biology of the DBG. The conference programme covers biological systematics in the widest sense and provides ample opportunities for oral and poster presentations on new advances in plant, animal and microbial systematics. This volume brings together the abstracts of invited speaches from the plenary sessions on Progress in Deep Phylogeny, Speciation and Phylogeography, and New Trends in Biological Systematics as well as those of submitted talks and poster sessions.The Göttingen conference Systematics 2008 is the first joint meeting of the Gesellschaft für Biologische Systematik (GfBp. and the German Botanical Society, section Biodiversity and Evolutionary Biology (DBG), being the 10th Annual Meeting of the GfBS and the 18th International Symposium Biodiversity and Evolutionary Biology of the DBG. The conference programme covers biological systematics in the widest sense and provides ample opportunities for oral and poster presentations on new advances in plant, animal and microbial systematics. This volume brings together the abstracts of invited speaches from the plenary sessions on Progress in Deep Phylogeny, Speciation and Phylogeography, and New Trends in Biological Systematics as well as those of submitted talks and poster sessions.Kongress: International Symposium Biodiversity and Evolutionary Biology ; 18 (Göttingen) : 2008.04.07-11 Annual meeting of the Gesellschaft für Biologische Systematik ; 10 (Göttingen) : 2008.04.07-11 Joint meeting of the Gesellschaft für Biologische Systematik and the German Botanical Society, Section Biodiversity and Evolutionary Biology ; 1 (Göttingen): 2008.04.07-1

Systematics 2008

The Göttingen conference „Systematics 2008“ is the first joint meeting of the Gesellschaft für Biologische Systematik (GfBS) and the German Botanical Society, section Biodiversity and Evolutionary Biology (DBG), being the 10th Annual Meeting of the GfBS and the 18th International Symposium „Biodiversity and Evolutionary Biology“ of the DBG. The conference programme covers biological systematics in the widest sense and provides ample opportunities for oral and poster presentations on new advances in plant, animal and microbial systematics. This volume brings together the abstracts of invited speaches from the plenary sessions on „Progress in Deep Phylogeny“, „Speciation and Phylogeography“, and „New Trends in Biological Systematics“ as well as those of submitted talks and poster sessions