Heart Rate Variability Dynamics for the Prognosis of Cardiovascular Risk

Statistical, spectral, multi-resolution and non-linear methods were applied to heart rate variability (HRV) series linked with classification schemes for the prognosis of cardiovascular risk. A total of 90 HRV records were analyzed: 45 from healthy subjects and 45 from cardiovascular risk patients. A total of 52 features from all the analysis methods were evaluated using standard two-sample Kolmogorov-Smirnov test (KS-test). The results of the statistical procedure provided input to multi-layer perceptron (MLP) neural networks, radial basis function (RBF) neural networks and support vector machines (SVM) for data classification. These schemes showed high performances with both training and test sets and many combinations of features (with a maximum accuracy of 96.67%). Additionally, there was a strong consideration for breathing frequency as a relevant feature in the HRV analysis

Heart Rate Variability Dynamics for the Prognosis of Cardiovascular Risk

Statistical, spectral, multi-resolution and non-linear methods were applied to heart rate variability (HRV) series linked with classification schemes for the prognosis of cardiovascular risk. A total of 90 HRV records were analyzed: 45 from healthy subjects and 45 from cardiovascular risk patients. A total of 52 features from all the analysis methods were evaluated using standard two-sample Kolmogorov-Smirnov test (KS-test). The results of the statistical procedure provided input to multi-layer perceptron (MLP) neural networks, radial basis function (RBF) neural networks and support vector machines (SVM) for data classification. These schemes showed high performances with both training and test sets and many combinations of features (with a maximum accuracy of 96.67%). Additionally, there was a strong consideration for breathing frequency as a relevant feature in the HRV analysis

The effect of spontaneous versus paced breathing on EEG, HRV, skin conductance and skin temperature

A dissertation submitted in fulfilment of the requirements for the degree Master of Science in Engineering, in the Faculty of Engineering and the Built Environment, University of the Witwatersrand, Johannesburg. January 2017 JohannesburgIt is well known that emotional stress has a negative impact on people’s health and physical, emotional and mental performance. Previous research has investigated the effects of stress on various aspects of physiology such as respiration, heart rate, heart rate variability (HRV), skin conductance, skin temperature and electrical activity in the brain. Essentially, HRV, Electroencephalography (EEG), skin conductance and skin temperature appear to reflect a stress response or state of arousal. Whilst the relationship between respiration rate, respiration rhythm and HRV is well documented, less is known about the relationship between respiration rate, EEG, skin conductance and skin temperature, whilst HRV is maximum (when there is resonance between HRV and respiration i.e. in phase with one another). This research project aims to investigate the impact that one session of slow paced breathing has on EEG, heart rate variability (HRV), skin conductance and skin temperature. Twenty male participants were randomly assigned to either a control or intervention group. Physiological data were recorded for the intervention and control group during one breathing session, over a short initial baseline (B1), a main session of 12 minutes, and a final baseline (B2). The only difference between the control and intervention groups was that during the main session, the intervention group practiced slow paced breathing (at 6 breaths per minute), while the control group breathed spontaneously. Wavelet transformation was used to analyse EEG data while Fourier transformation was used to analyse HRV. The study shows that slow-paced breathing significantly increases the low frequency and total power of the HRV but does not change the high frequency power of HRV. Furthermore, skin temperature significantly increased for the control group from B1 to Main, and was significantly higher for the control group when compared to the intervention group during the main session. There were no significant skin temperature changes between sessions for the intervention group. Skin conductance increased significantly from Main to B2 for the control group. No significant changes were found between sessions for the intervention group and between groups. EEG theta power at Cz decreased significantly from Main to B2 for the control group only, while theta power decreased at F4 from Main to B2 for both groups. Lastly, beta power at Cz decreased from B1 to B2 for the control group only. This significant effect that slow-paced breathing has on HRV suggests the hypothesis that with frequent practice, basal HRV would increase, and with it, potential benefits such as a reduction in anxiety and improved performance in specific tasks. Slow-paced breathing biofeedback thus shows promise as a simple, cheap, measurable and effective method to reduce the impact of stress on some physiological signals, suggesting a direction for future research.MT201

A Multi-Tier Distributed fog-based Architecture for Early Prediction of Epileptic Seizures

Epilepsy is the fourth most common neurological problem. With 50 million people living with epilepsy worldwide, about one in 26 people will continue experiencing recurring seizures during their lifetime. Epileptic seizures are characterized by uncontrollable movements and can cause loss of awareness. Despite the optimal use of antiepileptic medications, seizures are still difficult to control due to their sudden and unpredictable nature. Such seizures can put the lives of patients and others at risk. For example, seizure attacks while patients are driving could affect their ability to control a vehicle and could result in injuries to the patients as well as others. Notifying patients before the onset of seizures can enable them to avoid risks and minimize accidents, thus, save their lives. Early and accurate prediction of seizures can play a significant role in improving patients’ quality of life and helping doctors to administer medications through providing a historical overview of patient's condition over time. The individual variability and the dynamic disparity in differentiating between the pre-ictal phase (a period before the onset of the seizure) and other seizures phases make the early prediction of seizures a challenging task. Although several research projects have focused on developing a reliable seizure prediction model, numerous challenges still exist and need to be addressed. Most of the existing approaches are not suitable for real-time settings, which requires bio-signals collection and analysis in real-time. Various methods were developed based on the analysis of EEG signals without considering the notification latency and computational cost to support monitoring of multiple patients. Limited approaches were designed based on the analysis of ECG signals. ECG signals can be collected using consumer wearable devices and are suitable for light-weight real-time analysis. Moreover, existing prediction methods were developed based on the analysis of seizure state and ignored the investigation of pre-ictal state. The analysis of the pre-ictal state is essential in the prediction of seizures at an early stage. Therefore, there is a crucial need to design a novel computing model for early prediction of epileptic seizures. This model would greatly assist in improving the patients' quality of lives. This work proposes a multi-tier architecture for early prediction of seizures based on the analysis of two vital signs, namely, Electrocardiography (ECG) and Electroencephalogram (EEG) signals. The proposed architecture comprises of three tiers: (1) sensing at the first tier, (2) lightweight analysis based on ECG signals at the second tier, and (3) deep analysis based on EEG signals at the third tier. The proposed architecture is developed to leverage the potential of fog computing technology at the second tier for a real-time signal analytics and ubiquitous response. The proposed architecture can enable the early prediction of epileptic seizures, reduce the notification latency, and minimize the energy consumption on real-time data transmissions. Moreover, the proposed architecture is designed to allow for both lightweight and extensive analytics, thus make accurate and reliable decisions. The proposed lightweight model is formulated using the analysis of ECG signals to detect the pre-ictal state. The lightweight model utilizes the Least Squares Support Vector Machines (LS-SVM) classifier, while the proposed extensive analytics model analyzes EEG signals and utilizes Deep Belief Network (DBN) to provide an accurate classification of the patient’s state. The performance of the proposed architecture is evaluated in terms of latency minimization and energy consumption in comparison with the cloud. Moreover, the performance of the proposed prediction models is evaluated using three datasets. Various performance metrics were used to investigate the prediction model performance, including: accuracy, sensitivity, specificity, and F1-Measure. The results illustrate the merits of the proposed architecture and show significant improvement in the early prediction of seizures in terms of accuracy, sensitivity, and specificity

On optimal design and applications of linear transforms

Linear transforms are encountered in many fields of applied science and engineering. In the past, conventional block transforms provided acceptable answers to different practical problems. But now, under increasing competitive pressures, with the growing reservoir of theory and a corresponding development of computing facilities, a real demand has been created for methods that systematically improve performance. As a result the past two decades have seen the explosive growth of a class of linear transform theory known as multiresolution signal decomposition. The goal of this work is to design and apply these advanced signal processing techniques to several different problems. The optimal design of subband filter banks is considered first. Several design examples are presented for M-band filter banks. Conventional design approaches are found to present problems when the number of constraints increases. A novel optimization method is proposed using a step-by-step design of a hierarchical subband tree. This method is shown to possess performance improvements in applications such as subband image coding. The subband tree structuring is then discussed and generalized algorithms are presented. Next, the attention is focused on the interference excision problem in direct sequence spread spectrum (DSSS) communications. The analytical and experimental performance of the DSSS receiver employing excision are presented. Different excision techniques are evaluated and ranked along with the proposed adaptive subband transform-based excises. The robustness of the considered methods is investigated for either time-localized or frequency-localized interferers. A domain switchable excision algorithm is also presented. Finally, sonic of the ideas associated with the interference excision problem are utilized in the spectral shaping of a particular biological signal, namely heart rate variability. The improvements for the spectral shaping process are shown for time-frequency analysis. In general, this dissertation demonstrates the proliferation of new tools for digital signal processing

MicroECG: an integrated platform for the cardiac arrythmia detection and characterization

Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do grau de Mestre em Engenharia Electrotécnica e ComputadoresO desenvolvimento de um pacote de software para lidar facilmente com electrocardiogramas de alta resolução tornou-se importante para pesquisa na área de electrocardiografia. O desenvolvimento de novas técnicas para detecção de potenciais tardios e outros problemas associados a arritmias cardíacas têm sido objecto de estudo ao longo dos anos. No entanto, ainda existe a lacuna de um pacote de software que facilmente permita implementar algumas destas inovadoras técnicas de uma forma integrada, possibilitando avaliar técnicas clássicas como o protocolo de Simson para a detecção de sinais não estacionários (potenciais tardios). Algumas destas inovadoras técnicas envolvem a detecção tempo-frequência usando escalogramas ou a análise espectral usando metodologias wavelet-packet, sendo implementadas no software desenvolvido com flexibilidade e versatilidade suficientes para que futuramente sirva de plataforma de pesquisa para o refinamento destas mesmas técnicas no que toca ao processamento de sinais de electrocardiogramas de alta resolução. O software aqui desenvolvido foi também desenhado de forma a suportar dois tipos de ficheiros diferentes provenientes de outros tantos sistemas de aquisição. Os sistemas suportados são o ActiveTwo da Biosemi e o USBamp da g.tec

Heart Rate Variability analysis in patients undergoing local anesthesia

The analysis of Heart Rate Variability (HRV), the beat to beat fluctuation in the heart rate, is a non-invasive technique with a main aim in gaining information about the autonomic neural regulation of the heart. Assessment of HRV has been shown to aid clinical diagnosis and intervention strategies. However, there are quite a few conflicting reports on HRV that perhaps impede its use as a reliable clinical tool. The complex nature of different mechanisms that affect the HRV and the large number of signal processing techniques that have been used for HRV analysis are the contributing factors of these conflicting results. The aim of this study was to investigate for the first time the effect of HRV during Brachial plexus block (local anaesthesia), applied using the axillary approach. The hypothesis was that, such investigation will enable the detection of possible changes in the dynamics of the cardiovascular system due to the intravenous introduction of anaesthetic drugs during local anaesthesia. For this purpose advanced HRV signals processing techniques were developed and evaluated on data collected before and after the application of the Brachial plexus block from fourteen patients undergoing local anaesthesia. Signal processing techniques for R-wave detection, signal representation, ectopic beat detection and detrending were first developed and validated with the help of simulated signals and physiological signals from Physionet data base. After the validation stage these methods were then used to analyse the data from the locally anaesthetised patients. The ECG R-wave peak detection was carried out using the wavelet transform with first derivative of Gaussian smoothing function as the mother wavelet. The algorithm achieved accuracy and sensitivity of over 90%. The heart timing signal was used for the HRV signal representation and also for the correction of missing and/or ectopic beats. The results obtained from the ectopic beat correction algorithm showed that the algorithm managed to significantly reduce the error caused by missing and/or ectopic beats. Detrending of the HRV signal was carried out using the wavelet packet analysis algorithm which was specifically developed for this study. The respiration signal was also estimaited from the ECG signal using the ECG Derived Respiration (EDR) technique. In order to take better account of slow respiration rates and/or irregular respiratory patterns in the HRV analysis, a new method for the estimation of the variable boundaries associated with the LF and the HF band of the HRV signal was implemented. This method relies on the frequency contents of both the HRV signal and the respiration signal and uses the cross-spectrum between these two signals to obtain the boundaries related to the HF band of the signal. The boundaries related to the LF band were defined using the HRV signal spectrum alone. The boundary estimation technique was applicable in all the spectral analysis methods that were used in this study. After the pre-processing steps the clinical data was analysed using frequency and timefrequency analysis methods to obtain the parameters related to the HRV signals. Initially spectral analysis was carried out using the traditional non-parametric (Welch’s periodogram) and parametric (Autoregressive modelling) methods. Statistical analysis of the parameters obtained from both the non-parametric and the parametric methods showed significant decrease in the LF/HF ratio values within an hour of application of the block in nine out of fourteen patients. In order to overcome the inability of these methods to deal with non-stationary, time-frequency analysis techniques were used to further analyse the HRV signals. The three time-frequency analysis methods used were the ContinuousWavelet Transform (CWT), theWigner-Ville Distribution (SPWVD) and the Empirical Mode Decomposition (EMD). The analysis of the parameters estimated from these three techniques on the clinical data showed that the CWT and the EMD techniques have performed equivalently, meaning that both these methods have detected significant decrease in thirteen out of fourteen patients for the ratio values after the application of the,anaesthetic block. The presence of interference terms has caused the degradation in the performance of the SPWVD method and due to this reason it was only able to detect significant changes in the LF/HF ratio values in ten of the fourteen patients. The results suggest that due to anxiety and/or adrenaline present in the local anaesthetic mixture, the LF/HF ratio values showed a transient increase shortly after the application of the block. After this transient increase the ratio values decreased considerably and remained low as compared to the values before the application of the block. This decrease could represent the shift of the sympathovagal balance towards parasympathetic predominance and/or inhabitation of sympathetic activity due to local anaesthesia. The use of timefrequency analysis such as EMD and CWT could provide useful information about the changes caused in the dynamics of the cardiovascular system when a local anaesthetic drug is administered in a patient

A systematic review of physiological signals based driver drowsiness detection systems.

Driving a vehicle is a complex, multidimensional, and potentially risky activity demanding full mobilization and utilization of physiological and cognitive abilities. Drowsiness, often caused by stress, fatigue, and illness declines cognitive capabilities that affect drivers' capability and cause many accidents. Drowsiness-related road accidents are associated with trauma, physical injuries, and fatalities, and often accompany economic loss. Drowsy-related crashes are most common in young people and night shift workers. Real-time and accurate driver drowsiness detection is necessary to bring down the drowsy driving accident rate. Many researchers endeavored for systems to detect drowsiness using different features related to vehicles, and drivers' behavior, as well as, physiological measures. Keeping in view the rising trend in the use of physiological measures, this study presents a comprehensive and systematic review of the recent techniques to detect driver drowsiness using physiological signals. Different sensors augmented with machine learning are utilized which subsequently yield better results. These techniques are analyzed with respect to several aspects such as data collection sensor, environment consideration like controlled or dynamic, experimental set up like real traffic or driving simulators, etc. Similarly, by investigating the type of sensors involved in experiments, this study discusses the advantages and disadvantages of existing studies and points out the research gaps. Perceptions and conceptions are made to provide future research directions for drowsiness detection techniques based on physiological signals. [Abstract copyright: © The Author(s), under exclusive licence to Springer Nature B.V. 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

A Physiological Signal Processing System for Optimal Engagement and Attention Detection.

In today’s high paced, hi-tech and high stress environment, with extended work hours, long to-do lists and neglected personal health, sleep deprivation has become common in modern culture. Coupled with these factors is the inherent repetitious and tedious nature of certain occupations and daily routines, which all add up to an undesirable fluctuation in individuals’ cognitive attention and capacity. Given certain critical professions, a momentary or prolonged lapse in attention level can be catastrophic and sometimes deadly. This research proposes to develop a real-time monitoring system which uses fundamental physiological signals such as the Electrocardiograph (ECG), to analyze and predict the presence or lack of cognitive attention in individuals during task execution. The primary focus of this study is to identify the correlation between fluctuating level of attention and its implications on the physiological parameters of the body. The system is designed using only those physiological signals that can be collected easily with small, wearable, portable and non-invasive monitors and thereby being able to predict well in advance, an individual’s potential loss of attention and ingression of sleepiness. Several advanced signal processing techniques have been implemented and investigated to derive multiple clandestine and informative features. These features are then applied to machine learning algorithms to produce classification models that are capable of differentiating between the cases of a person being attentive and the person not being attentive. Furthermore, Electroencephalograph (EEG) signals are also analyzed and classified for use as a benchmark for comparison with ECG analysis. For the study, ECG signals and EEG signals of volunteer subjects are acquired in a controlled experiment. The experiment is designed to inculcate and sustain cognitive attention for a period of time following which an attempt is made to reduce cognitive attention of volunteer subjects. The data acquired during the experiment is decomposed and analyzed for feature extraction and classification. The presented results show that to a fairly reasonable accuracy it is possible to detect the presence or lack of attention in individuals with just their ECG signal, especially in comparison with analysis done on EEG signals. The continual work of this research includes other physiological signals such as Galvanic Skin Response, Heat Flux, Skin Temperature and video based facial feature analysis

Bio-Radar: sistema de aquisição de sinais vitais sem contacto

The Bio-Radar system is capable to measure vital signs accurately, namely the respiratory and cardiac signal, using electromagnetic waves. In this way, it is possible to monitor subjects remotely and comfortably for long periods of time. This system is based on the micro-Doppler effect, which relates the received signal phase variation with the distance change between the subject chest-wall and the radar antennas, which occurs due to the cardiopulmonary function. Considering the variety of applications where this system can be used, it is required to evaluate its performance when applied to real context scenarios and thus demonstrate the advantages that bioradar systems can bring to the general population. In this work, a bio-radar prototype was developed in order to verify the viability to be integrated in specific applications, using robust and low profile solutions that equally guarantee the general system performance while addressing the market needs. Considering these two perspectives to be improved, different level solutions were developed. On the hardware side, textile antennas were developed to be embedded in a car seat upholstery, thus reaching a low profile solution and easy to include in the industrialization process. Real context scenarios imply long-term monitoring periods, where involuntary body motion can occur producing high amplitude signals that overshadow the vital signs. Non-controlled monitoring environments might also produce time varying parasitic reflections that have a direct impact in the signal. Additionally, the subject's physical stature and posture during the monitoring period can have a different impact in the signals quality. Therefore, signal processing algorithms were developed to be robust to low quality signals and non-static scenarios. On the other hand, the bio-radar potential can also be maximized if the acquired signals are used pertinently to help identify the subject's psychophysiological state enabling one to act accordingly. The random body motion until now has been seen as a noisy source, however it can also provide useful information regarding subject's state. In this sense, the acquired vital signs as well as other body motions were used in machine learning algorithms with the goal to identify the subject's emotions and thus verify if the remotely acquired vital signs can also provide useful information.O sistema Bio-Radar permite medir sinais vitais com precisão, nomeadamente o sinal respiratório e cardíaco, utilizando ondas eletromagnéticas para esse fim. Desta forma, é possível monitorizar sujeitos de forma remota e confortável durante longos períodos de tempo. Este sistema é baseado no efeito de micro-Doppler, que relaciona a variação de fase do sinal recebido com a alteração da distância entre as antenas do radar e a caixa torácica do sujeito, que ocorre durante a função cardiopulmonar. Considerando a variedade de aplicações onde este sistema pode ser utilizado, é necessário avaliar o seu desempenho quando aplicado em contextos reais e assim demonstrar as vantagens que os sistemas bio-radar podem trazer à população geral. Neste trabalho, foi desenvolvido um protótipo do bio radar com o objetivo de verificar a viabilidade de integrar estes sistemas em aplicações específicas, utilizando soluções robustas e discretas que garantam igualmente o seu bom desempenho, indo simultaneamente de encontro às necessidades do mercado. Considerando estas duas perspetivas em que o sistema pode ser melhorado, foram desenvolvidas soluções de diferentes níveis. Do ponto de vista de hardware, foram desenvolvidas antenas têxteis para serem integradas no estofo de um banco automóvel, alcançando uma solução discreta e fácil de incluir num processo de industrialização. Contextos reais de aplicação implicam períodos de monitorização longos, onde podem ocorrer movimentos corporais involuntários que produzem sinais de elevada amplitude que se sobrepõem aos sinais vitais. Ambientes de monitorização não controlados podem produzir reflexões parasitas variantes no tempo que têm impacto direto no sinal. Adicionalmente, a estrutura física do sujeito e a sua postura durante o período de monitorização podem ter impactos diferentes na qualidade dos sinais. Desta forma, foram desenvolvidos algoritmos de processamento de sinal robustos a sinais de baixa qualidade e a cenários não estáticos. Por outro lado, o potencial do bio radar pode também ser maximizado se os sinais adquiridos forem pertinentemente utilizados de forma a ajudar a identificar o estado psicofisiológico do sujeito, permitindo mais tarde agir em conformidade. O movimento corporal aleatório que foi até agora visto como uma fonte de ruído, pode no entanto também fornecer informação útil sobre o estado do sujeito. Neste sentido, os sinais vitais e outros movimentos corporais adquiridos foram utilizados em algoritmos de aprendizagem automática com o objetivo de identificar as emoções do sujeito e assim verificar que sinais vitais adquiridos remotamente podem também conter informação útil.Programa Doutoral em Engenharia Eletrotécnic