Understanding Kernel Size in Blind Deconvolution

Most blind deconvolution methods usually pre-define a large kernel size to guarantee the support domain. Blur kernel estimation error is likely to be introduced, yielding severe artifacts in deblurring results. In this paper, we first theoretically and experimentally analyze the mechanism to estimation error in oversized kernel, and show that it holds even on blurry images without noises. Then to suppress this adverse effect, we propose a low rank-based regularization on blur kernel to exploit the structural information in degraded kernels, by which larger-kernel effect can be effectively suppressed. And we propose an efficient optimization algorithm to solve it. Experimental results on benchmark datasets show that the proposed method is comparable with the state-of-the-arts by accordingly setting proper kernel size, and performs much better in handling larger-size kernels quantitatively and qualitatively. The deblurring results on real-world blurry images further validate the effectiveness of the proposed method.Comment: Accepted by WACV 201

K-Nearest-Neighbors Induced Topological PCA for scRNA Sequence Data Analysis

Single-cell RNA sequencing (scRNA-seq) is widely used to reveal heterogeneity in cells, which has given us insights into cell-cell communication, cell differentiation, and differential gene expression. However, analyzing scRNA-seq data is a challenge due to sparsity and the large number of genes involved. Therefore, dimensionality reduction and feature selection are important for removing spurious signals and enhancing downstream analysis. Traditional PCA, a main workhorse in dimensionality reduction, lacks the ability to capture geometrical structure information embedded in the data, and previous graph Laplacian regularizations are limited by the analysis of only a single scale. We propose a topological Principal Components Analysis (tPCA) method by the combination of persistent Laplacian (PL) technique and L$_{2,1}$ norm regularization to address multiscale and multiclass heterogeneity issues in data. We further introduce a k-Nearest-Neighbor (kNN) persistent Laplacian technique to improve the robustness of our persistent Laplacian method. The proposed kNN-PL is a new algebraic topology technique which addresses the many limitations of the traditional persistent homology. Rather than inducing filtration via the varying of a distance threshold, we introduced kNN-tPCA, where filtrations are achieved by varying the number of neighbors in a kNN network at each step, and find that this framework has significant implications for hyper-parameter tuning. We validate the efficacy of our proposed tPCA and kNN-tPCA methods on 11 diverse benchmark scRNA-seq datasets, and showcase that our methods outperform other unsupervised PCA enhancements from the literature, as well as popular Uniform Manifold Approximation (UMAP), t-Distributed Stochastic Neighbor Embedding (tSNE), and Projection Non-Negative Matrix Factorization (NMF) by significant margins.Comment: 28 pages, 11 figure