Schemata as Building Blocks: Does Size Matter?

We analyze the schema theorem and the building block hypothesis using a recently derived, exact schemata evolution equation. We derive a new schema theorem based on the concept of effective fitness showing that schemata of higher than average effective fitness receive an exponentially increasing number of trials over time. The building block hypothesis is a natural consequence in that the equation shows how fit schemata are constructed from fit sub-schemata. However, we show that generically there is no preference for short, low-order schemata. In the case where schema reconstruction is favoured over schema destruction large schemata tend to be favoured. As a corollary of the evolution equation we prove Geiringer's theorem. We give supporting numerical evidence for our claims in both non-epsitatic and epistatic landscapes.Comment: 17 pages, 10 postscript figure

An Overview of Schema Theory

The purpose of this paper is to give an introduction to the field of Schema Theory written by a mathematician and for mathematicians. In particular, we endeavor to to highlight areas of the field which might be of interest to a mathematician, to point out some related open problems, and to suggest some large-scale projects. Schema theory seeks to give a theoretical justification for the efficacy of the field of genetic algorithms, so readers who have studied genetic algorithms stand to gain the most from this paper. However, nothing beyond basic probability theory is assumed of the reader, and for this reason we write in a fairly informal style. Because the mathematics behind the theorems in schema theory is relatively elementary, we focus more on the motivation and philosophy. Many of these results have been proven elsewhere, so this paper is designed to serve a primarily expository role. We attempt to cast known results in a new light, which makes the suggested future directions natural. This involves devoting a substantial amount of time to the history of the field. We hope that this exposition will entice some mathematicians to do research in this area, that it will serve as a road map for researchers new to the field, and that it will help explain how schema theory developed. Furthermore, we hope that the results collected in this document will serve as a useful reference. Finally, as far as the author knows, the questions raised in the final section are new.Comment: 27 pages. Originally written in 2009 and hosted on my website, I've decided to put it on the arXiv as a more permanent home. The paper is primarily expository, so I don't really know where to submit it, but perhaps one day I will find an appropriate journa

Efficient regularized isotonic regression with application to gene--gene interaction search

Isotonic regression is a nonparametric approach for fitting monotonic models to data that has been widely studied from both theoretical and practical perspectives. However, this approach encounters computational and statistical overfitting issues in higher dimensions. To address both concerns, we present an algorithm, which we term Isotonic Recursive Partitioning (IRP), for isotonic regression based on recursively partitioning the covariate space through solution of progressively smaller "best cut" subproblems. This creates a regularized sequence of isotonic models of increasing model complexity that converges to the global isotonic regression solution. The models along the sequence are often more accurate than the unregularized isotonic regression model because of the complexity control they offer. We quantify this complexity control through estimation of degrees of freedom along the path. Success of the regularized models in prediction and IRPs favorable computational properties are demonstrated through a series of simulated and real data experiments. We discuss application of IRP to the problem of searching for gene--gene interactions and epistasis, and demonstrate it on data from genome-wide association studies of three common diseases.Comment: Published in at http://dx.doi.org/10.1214/11-AOAS504 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org