Micromachined Ultrasonic Transducers for 3-D Imaging

Real-time ultrasound imaging is a widely used technique in medical diagnostics. Recently, ultrasound systems offering real-time imaging in 3-D has emerged. However, the high complexity of the transducer probes and the considerable increase in data to be processed compared to conventional 2-D ultrasound imaging results in expensive systems, which limits the more wide-spread use and clinical development of volumetric ultrasound. The main goal of this thesis is to demonstrate new transducer technologies that can achieve real-time volumetric ultrasound imaging without the complexity and cost of state-of-the-art 3-D ultrasound systems. The focus is on row-column addressed transducer arrays. This previously sparsely investigated addressing scheme offers a highly reduced number of transducer elements, resulting in reduced transducer manufacturing costs and data processing. To produce such transducer arrays, capacitive micromachined ultrasonic transducer (CMUT) technology is chosen for this project. Properties such as high bandwidth and high design flexibility makes this an attractive transducer technology, which is under continuous development in the research community. A theoretical treatment of CMUTs is presented, including investigations of the anisotropic plate behaviour and modal radiation patterns of such devices. Several new CMUT fabrication approaches are developed and investigated in terms of oxide quality and surface protrusions, culminating in a simple four-mask process capable of producing 62+62-element row-column addressed CMUT arrays with negligible charging issues. The arrays include an integrated apodization, which reduces the ghost echoes produced by the edge waves in such arrays by 15:8 dB. The acoustical cross-talk is measured on fabricated arrays, showing a 24 dB reduction in cross-talk compared to 1-D arrays for 2-D imaging. Volumetric imaging is successfully demonstrated using a beamformer specifically developed for row-column addressed arrays. Furthermore, a technique for estimating flow velocities in all three dimensions is presented. Based on the developed techniques, a complete hand-held 3MHz λ/2-pitch ultrasound probe for volumetric imaging with 62+62 elements and in-handle electronics is produced and used on a commercial bk3000 scanner from BK Medical. The scanner is made for conventional 2-D ultrasound imaging, proving that the developed technology enables realtime volumetric ultrasound imaging with a total system cost and complexity equivalent to that of 2-D ultrasound imaging systems

Communications Biophysics

Contains reports on seven research projects split into three sections, with research objective for the final section.National Institutes of Health (Grant 2 PO1 NS 13126)National Institutes of Health (Grant 5 RO1 NS 18682)National Institutes of Health (Grant 1 RO1 NS 20322)National Institutes of Health (Grant 1 RO1 NS 20269)National Institutes of Health (Grant 5 T32 NS 07047)Symbion, Inc.National Institutes of Health (Grant 5 RO1 NS10916)National Institutes of Health (Grant 1 RO1 NS16917)National Science Foundation (Grant BNS83-19874)National Science Foundation (Grant BNS83-19887)National Institutes of Health (Grant 5 RO1 NS12846)National Institutes of Health (Grant 5 RO1 NS21322)National Institutes of Health (Grant 5 RO1 NS 11080

The VHP-F Computational Phantom and its Applications for Electromagnetic Simulations

Modeling of the electromagnetic, structural, thermal, or acoustic response of the human body to various external and internal stimuli is limited by the availability of anatomically accurate and numerically efficient computational models. The models currently approved for use are generally of proprietary or fixed format, preventing new model construction or customization. 1. This dissertation develops a new Visible Human Project - Female (VHP-F) computational phantom, constructed via segmentation of anatomical cryosection images taken in the axial plane of the human body. Its unique property is superior resolution on human head. In its current form, the VHP-F model contains 33 separate objects describing a variety of human tissues within the head and torso. Each obejct is a non-intersecting 2-manifold model composed of contiguous surface triangular elements making the VHP-F model compatible with major commercial and academic numerical simulators employing the Finite Element Method (FEM), Boundary Element Method (BEM), Finite Volume Method (FVM), and Finite-Difference Time-Domain (FDTD) Method. 2. This dissertation develops a new workflow used to construct the VHP-F model that may be utilized to build accessible custom models from any medical image data source. The workflow is customizable and flexible, enabling the creation of standard and parametrically varying models facilitating research on impacts associated with fluctuation of body characteristics (for example, skin thickness) and dynamic processes such as fluid pulsation. 3. This dissertation identifies, enables, and quantifies three new specific computational bioelectromagnetic problems, each of which is solved with the help of the developed VHP-F model: I. Transcranial Direct Current Stimulation (tDCS) of human brain motor cortex with extracephalic versus cephalic electrodes; II. RF channel characterization within cerebral cortex with novel small on-body directional antennas; III. Body Area Network (BAN) characterization and RF localization within the human body using the FDTD method and small antenna models with coincident phase centers. Each of those problems has been (or will be) the subject of a separate dedicated MS thesis

1-D broadside-radiating leaky-wave antenna based on a numerically synthesized impedance surface

A newly-developed deterministic numerical technique for the automated design of metasurface antennas is applied here for the first time to the design of a 1-D printed Leaky-Wave Antenna (LWA) for broadside radiation. The surface impedance synthesis process does not require any a priori knowledge on the impedance pattern, and starts from a mask constraint on the desired far-field and practical bounds on the unit cell impedance values. The designed reactance surface for broadside radiation exhibits a non conventional patterning; this highlights the merit of using an automated design process for a design well known to be challenging for analytical methods. The antenna is physically implemented with an array of metal strips with varying gap widths and simulation results show very good agreement with the predicted performance