New insights on the ventral attention network::active suppression and involuntary recruitment during a bimodal task

International audienceDetection of unexpected, yet relevant events is essential in daily life. fMRI studies have revealed the involvement of the ventral attention network (VAN), including the temporo-parietal junction (TPJ), in such process. In this MEG study with 34 participants (17 women), we used a bimodal (visual/auditory) attention task to determine the neuronal dynamics associated with suppression of the activity of the VAN during top-down attention and its recruitment when information from the unattended sensory modality is involuntarily integrated. We observed an anticipatory power increase of alpha/beta oscillations (12–20 Hz, previously associated with functional inhibition) in the VAN following a cue indicating the modality to attend. Stronger VAN power increases were associated with better task performance, suggesting that the VAN suppression prevents shifting attention to distractors. Moreover, the TPJ was synchronized with the frontal eye field in that frequency band, indicating that the dorsal attention network (DAN) might participate in such suppression. Furthermore, we found a 12–20 Hz power decrease and enhanced synchronization, in both the VAN and DAN, when information between sensory modalities was congruent, suggesting an involvement of these networks when attention is involuntarily enhanced due to multisensory integration. Our results show that effective multimodal attentional allocation includes the modulation of the VAN and DAN through upper-alpha/beta oscillations. Altogether these results indicate that the suppressing role of alpha/beta oscillations might operate beyond sensory regions

Subjective pain perception mediated by alpha rhythms

Suppression of spontaneous alpha oscillatory activities, interpreted as cortical excitability, was observed in response to both transient and tonic painful stimuli. The changes of alpha rhythms induced by pain could be modulated by painful sensory inputs, experimental tasks, and top-down cognitive regulations such as attention. The temporal and spatial characteristics, as well as neural functions of pain induced alpha responses, depend much on how these factors contribute to the observed alpha event-related desynchronization/synchronization (ERD/ERS). How sensory-, task-, and cognitive-related changes of alpha oscillatory activities interact in pain perception process is reviewed in the current study, and the following conclusions are made: (1) the functional inhibition hypothesis that has been proposed in auditory and visual modalities could be applied also in pain modality; (2) the neural functions of pain induced alpha ERD/ERS were highly dependent on the cortical regions where it is observed, e.g., somatosensory cortex alpha ERD/ERS in pain perception for painful stimulus processing; (3) the attention modulation of pain perception, i.e., influences on the sensory and affective dimensions of pain experience, could be mediated by changes of alpha rhythms. Finally, we propose a model regarding the determinants of pain related alpha oscillatory activity, i.e., sensory-discriminative, affective-motivational, and cognitive-modulative aspects of pain experience, would affect and determine pain related alpha oscillatory activities in an integrated way within the distributed alpha system. Copyright © 2015 Elsevier B.V. All rights reserved.postprin

Neural entrainment to the beat in multiple frequency bands in 6-7-year-old children

Entrainment to periodic acoustic stimuli has been found to relate both to the auditory and motor cortices, and it could be influenced by the maturity of these brain regions. However, existing research in this topic provides data about different oscillatory brain activities in different age groups with different musical background. In order to obtain a more coherent picture and examine early manifestations of entrainment, we assessed brain oscillations at multiple time scales (beta: 15-25 Hz, gamma: 28-48 Hz) and in steady state evoked potentials (SS-EPs in short) in 6-7-year-old children with no musical background right at the start of primary school before they learnt to read. Our goal was to exclude the effect of music training and reading, since previous studies have shown that sensorimotor entrainment (movement synchronization to the beat) is related to musical and reading abilities. We found evidence for endogenous anticipatory processing in the gamma band related to meter perception, and stimulus-related frequency specific responses. However, we did not find evidence for an interaction between auditory and motor networks, which suggests that endogenous mechanisms related to auditory processing may mature earlier than those that underlie motor actions, such as sensorimotor synchronization

The neurophysiology of intersensory selective attention and task switching

Our ability to selectively attend to certain aspects of the world and ignore others is fundamental to our day-to-day lives. The need for selective attention stems from capacity limitations inherent in our perceptual and cognitive processing architecture. Because not every elemental piece of our environment can be fully processed in parallel, the nervous system must prioritize processing. This prioritization is generally referred to as selective attention. Meanwhile, we are faced with a world that is constantly in flux, such that we have to frequently shift our attention from one piece of the environment to another and from one task to another. This process is generally referred to as task-switching. Neural oscillations in the alpha band (~8-14 Hz) have been shown to index the distribution of selective attention, and there is increasing evidence that oscillations in this band are in fact utilized by the nervous system to suppress distracting, task-irrelevant information. In order to elaborate on what is known of the function of alpha oscillations as well as current models of both intersensory selective attention and task switching, I investigated the dynamics of alpha amplitude modulations within the context of intersenory selective attention and task switching in neurologically typical young adults. Participants were alternately cued to attend to either the visual or auditory aspect of a compound audio-visual stimulus while high-density electroencephalography was recorded. It is typically found that alpha power increases over parieto-occipital cortices when attention is directed away from the visual modality and to the auditory modality. I report evidence that alpha oscillations play a role in task-switching (e.g., when switching from attending the visual task versus repeating this task), specifically as biasing signals, that may operate to re-weight competition among two tasks-sets. I further investigated the development of these same processes in school-aged children and adolescents. While exhibiting typical patterns of alpha modulations relevant to selective attention, Young school-aged children (8-12 years), compared to older participants, did not demonstrate specific task switching modulation of alpha oscillations, suggesting that this process does not fully develop until late adolescence. Finally, children and adolescents on the autism spectrum failed altogether to exhibit differentiation of alpha power between attend-visual and attend-auditory conditions--an effect present in age and IQ matched controls--suggesting that ASD individuals may have a deficit in the overall top-down deployment of alpha oscillatory biasing signals. This could result in an inability to ignore distracting information in the environment, leading to an overwhelming, disordered experience of the world, resulting in profound effects on the both social interaction and cognitive development. Altogether, these findings add to growing evidence that alpha oscillations serve as domain general biasing signals and are integral to our flexible goal-oriented behavior. Furthermore, the flexible use of these biasing signals in selective attention and task switching develops over a protracted period, and appears to be aberrant in autism spectrum disorder

Formation of visual memories controlled by gamma power phase-locked to alpha oscillations

Neuronal oscillations provide a window for understanding the brain dynamics that organize the flow of information from sensory to memory areas. While it has been suggested that gamma power reflects feedforward processing and alpha oscillations feedback control, it remains unknown how these oscillations dynamically interact. Magnetoencephalography (MEG) data was acquired from healthy subjects who were cued to either remember or not remember presented pictures. Our analysis revealed that in anticipation of a picture to be remembered, alpha power decreased while the cross-frequency coupling between gamma power and alpha phase increased. A measure of directionality between alpha phase and gamma power predicted individual ability to encode memory: stronger control of alpha phase over gamma power was associated with better memory. These findings demonstrate that encoding of visual information is reflected by a state determined by the interaction between alpha and gamma activity

The Role of Alpha-Band Brain Oscillations as a Sensory Suppression Mechanism during Selective Attention

Evidence has amassed from both animal intracranial recordings and human electrophysiology that neural oscillatory mechanisms play a critical role in a number of cognitive functions such as learning, memory, feature binding and sensory gating. The wide availability of high-density electrical and magnetic recordings (64–256 channels) over the past two decades has allowed for renewed efforts in the characterization and localization of these rhythms. A variety of cognitive effects that are associated with specific brain oscillations have been reported, which range in spectral, temporal, and spatial characteristics depending on the context. Our laboratory has focused on investigating the role of alpha-band oscillatory activity (8–14 Hz) as a potential attentional suppression mechanism, and this particular oscillatory attention mechanism will be the focus of the current review. We discuss findings in the context of intersensory selective attention as well as intrasensory spatial and feature-based attention in the visual, auditory, and tactile domains. The weight of evidence suggests that alpha-band oscillations can be actively invoked within cortical regions across multiple sensory systems, particularly when these regions are involved in processing irrelevant or distracting information. That is, a central role for alpha seems to be as an attentional suppression mechanism when objects or features need to be specifically ignored or selected against

Functional Roles of Alpha-Band Phase Synchronization in Local and Large-Scale Cortical Networks

Alpha-frequency band (8–14 Hz) oscillations are among the most salient phenomena in human electroencephalography (EEG) recordings and yet their functional roles have remained unclear. Much of research on alpha oscillations in human EEG has focused on peri-stimulus amplitude dynamics, which phenomenologically support an idea of alpha oscillations being negatively correlated with local cortical excitability and having a role in the suppression of task-irrelevant neuronal processing. This kind of an inhibitory role for alpha oscillations is also supported by several functional magnetic resonance imaging and trans-cranial magnetic stimulation studies. Nevertheless, investigations of local and inter-areal alpha phase dynamics suggest that the alpha-frequency band rhythmicity may play a role also in active task-relevant neuronal processing. These data imply that inter-areal alpha phase synchronization could support attentional, executive, and contextual functions. In this review, we outline evidence supporting different views on the roles of alpha oscillations in cortical networks and unresolved issues that should be addressed to resolve or reconcile these apparently contrasting hypotheses

Task relevance modulates the behavioural and neural effects of sensory predictions

The brain is thought to generate internal predictions to optimize behaviour. However, it is unclear whether predictions signalling is an automatic brain function or depends on task demands. Here, we manipulated the spatial/temporal predictability of visual targets, and the relevance of spatial/temporal information provided by auditory cues. We used magnetoencephalography (MEG) to measure participants' brain activity during task performance. Task relevance modulated the influence of predictions on behaviour: spatial/temporal predictability improved spatial/temporal discrimination accuracy, but not vice versa. To explain these effects, we used behavioural responses to estimate subjective predictions under an ideal-observer model. Model-based time-series of predictions and prediction errors (PEs) were associated with dissociable neural responses: predictions correlated with cue-induced beta-band activity in auditory regions and alpha-band activity in visual regions, while stimulus-bound PEs correlated with gamma-band activity in posterior regions. Crucially, task relevance modulated these spectral correlates, suggesting that current goals influence PE and prediction signalling

Communication between Brain Areas Based on Nested Oscillations

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