Alzheimers Disease Diagnosis by Deep Learning Using MRI-Based Approaches

The most frequent kind of dementia of the nervous system, Alzheimer's disease, weakens several brain processes (such as memory) and eventually results in death. The clinical study uses magnetic resonance imaging to diagnose AD. Deep learning algorithms are capable of pattern recognition and feature extraction from the inputted raw data. As early diagnosis and stage detection are the most crucial elements in enhancing patient care and treatment outcomes, deep learning algorithms for MRI images have recently allowed for diagnosing a medical condition at the beginning stage and identifying particular symptoms of Alzheimer's disease. As a result, we aimed to analyze five specific studies focused on AD diagnosis using MRI-based deep learning algorithms between 2021 and 2023 in this study. To completely illustrate the differences between these techniques and comprehend how deep learning algorithms function, we attempted to explore selected approaches in depth

Staging of Alzheimer's disease based on MRI using CNN

Early detection of chronic diseases and determining the stages of damage to the patient is considered one of the most important stages of treatment, as it helps doctors take important remedial measures that help the patient recover or reduce the risk of the disease to a minimum. Alzheimer's disease is one of the neurological diseases that lead to brain atrophy, which leads to the loss of its functions. MRI images of the brain are used to detect Alzheimer's disease, but it is difficult to determine both the stages of the disease and the amount of damage in a patient using this MRI technique. In this research, we aim to detect Alzheimer's disease in addition to determining its stage based on deep learning techniques by using a classifier that uses the convolutional neural network (CNN). In the research, magnetic resonance images of the brain were used, and the hippocampus region was extracted in assessing the amount of damage because it is the most important region in diagnosing damage to the disease and reduce the amount of data entered into the neural network, our results show an accuracy of 95% in estimating brain damage. The results of the classifier used were able to determine the amount of damage according to four stages of the disease

A Multi-Modal Deep Learning Approach to the Early Prediction of Mild Cognitive Impairment Conversion to Alzheimer's Disease

Mild cognitive impairment (MCI) has been described as the intermediary stage before Alzheimer's Disease - many people however remain stable or even demonstrate improvement in cognition. Early detection of progressive MCI (pMCI) therefore can be utilised in identifying at-risk individuals and directing additional medical treatment in order to revert conversion to AD as well as provide psychosocial support for the person and their family.This paper presents a novel solution in the early detection of pMCI people and classification of AD risk within MCI people. We proposed a model, MudNet, to utilise deep learning in the simultaneous prediction of progressive/stable MCI classes and time-to-AD conversion where high-risk pMCI people see conversion to AD within 24 months and low-risk people greater than 24 months. MudNet is trained and validated using baseline clinical and volumetric MRI data (n = 559 scans) from participants of the Alzheimer's Disease Neuroimaging Initiative (ADNI). The model utilises T1-weighted structural MRIs alongside clinical data which also contains neuropsychological (RAVLT, ADAS-11, ADAS-13, ADASQ4, MMSE) tests as inputs.The averaged results of our model indicate a binary accuracy of 69.8% for conversion predictions and a categorical accuracy of 66.9% for risk classifications

Machine Learning for Detection of Cognitive Impairment

The detection of cognitive problems, especially in the early stages, is critical and the method by which it is diagnosed is manual and depends on one or more specialist doctors, to diagnose it as the cognitive decline escalates into the early stage of dementia, e.g., Alzheimer's disease (AD). The early stages of AD are very similar to Mild Cognitive Impairment (MCI); it is essential to identify the possible factors associated with the disease. This research aims to demonstrate that automated models can differentiate and classify MCI and AD in the early stages. The present research used a combination of Machine Learning (ML) algorithms to identify AD, using gene expressions. The algorithms used for the classification of cognitive problems and healthy people (control) were: Linear Regression, Decision Trees (DT), Naîve Bayes (NB) and Deep Learning (DP). The result of this research shows ML algorithms can identify AD, in early stages, with an 80% accuracy, using a Deep Learning (DL) algorithm.Fil: Diaz, Valeria. Universidad de Palermo. Facultad de Ingeniería; ArgentinaFil: Rodríguez, Guillermo Horacio. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Instituto de Sistemas Tandil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Instituto Superior de Ingeniería del Software. Universidad Nacional del Centro de la Provincia de Buenos Aires. Instituto Superior de Ingeniería del Software; Argentin