The roles of endoglin gene in cerebrovascular diseases.

Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis. Angiogenesis is important in the development of cerebral vasculature and in the pathogenesis of cerebral vascular diseases. ENG is an essential component of the endothelial nitric oxide synthase activation complex. Animal studies showed that ENG deficiency impairs stroke recovery. ENG deficiency also impairs the regulation of vascular tone, which contributes to the pathogenesis of brain arteriovenous malformation (bAVM) and vasospasm. In human, functional haploinsufficiency of ENG gene causes type I hereditary hemorrhagic telangiectasia (HHT1), an autosomal dominant disorder. Compared to normal population, HHT1 patients have a higher prevalence of AVM in multiple organs including the brain. Vessels in bAVM are fragile and tend to rupture, causing hemorrhagic stroke. High prevalence of pulmonary AVM in HHT1 patients are associated with a higher incidence of paradoxical embolism in the cerebral circulation causing ischemic brain injury. Therefore, HHT1 patients are at risk for both hemorrhagic and ischemic stroke. This review summarizes the possible mechanism of ENG in the pathogenesis of cerebrovascular diseases in experimental animal models and in patients

“Now you see me, now you don't": Dialogic loopholes in authorship activity with the very young

The genesis for this paper lies in the problematic nature of assessment practice, as a central authorship activity, for early childhood education teachers. This paper draws on dialogic philosophy to explore this challenge based on a doctoral investigation of a very young child (White, 2009) and the strategic means by which she reveals and conceals meaning through dialogic loopholes that are generated through eavesdropping tactics. The central argument made is that what can be seen and interpreted, when language is not shared between dialogic partners, is always and only an ontologic endeavour and never an epistemological truth. Seen in relation to the very young child, this tenet invites the potential to ‘see’ more and to move beyond narrow definitions of learning as an outcome of authorial intervention on the part of the teacher; to embrace uncertainty and difference as a central pedagogical stance; and to re-vision the infant as polyphonic hero in their own adventure plots

Minimum degrees for powers of paths and cycles

We study minimum degree conditions under which a graph $G$ contains $k^{th}$ power of paths and cycles of arbitrary specified lengths. We determine precise thresholds, assuming that the order of G is large. This extends a result of Allen, B\"ottcher and Hladk\'y concerning the containment of squares of paths and squares of cycles of arbitrary specified lengths and settles a conjecture of theirs in the affirmative.Comment: 69 pages, 3 figures. arXiv admin note: text overlap with arXiv:0906.3299 by other author

Evaluation of the performance of granular fertilizer boom sprayer through computational fluid-particles-dynamid CFD simulation and scaled-down model analysis

Malaysian Agricultural Research and Development Institute (MARDI) had bought two Japanese made granular fertilizer boom sprayers to test it on Malaysia’s Paddy field. In order to confirm the local feasibility of this fertilizer applicator, they had called UTHM researchers for proper experimental and numerical evaluations. A year of experimental assessments, the conclusion was supported with full range of numerical results and has a good agreement with MARDI’s findings. In this evaluation, ANSYS CFD was used for the fluid-particles-structure simulation while the statistical and image processing were made via MATLAB software. The simulation results were verified with the results from an in-house scaled-down model which was fabricated with the ratio of 2:15. The simulation was carried out by manipulating the angles of the boom sprayer collecting plates, ranging from 32o to 120o. The length of the collecting plate, the distance of the blow head, the sizes of the fertilizer and the air velocity of the blower were also varied in order to establish the correlations between the parameters. The ambient pressure was kept at 1 atm. Even though we managed to find 60o as the optimum collecting plate angle for most fertilizer sizes, there are two major factors that made it impossible to obtain good fertilizer distribution namely; the use of mixture of three different fertilizer (Nitrogen, Phosphorus and Potassium) sizes at once and the varying velocity profiles throughout the boom sprayer

Negative-Index Refraction in a Lamellar Composite with Alternating Single Negative Layers

Negative-index refraction is achieved in a lamellar composite with epsilon-negative (ENG) and mu-negative (MNG) materials stacked alternatively. Based on the effective medium approximation, simultaneously negative effective permittivity and permeability of such a lamellar composite are obtained theoretically and further proven by full-wave simulations. Consequently, the famous left-handed metamaterial comprising split ring resonators and wires is interpreted as an analogy of such an ENG-MNG lamellar composite. In addition, beyond the effective medium approximation, the propagating field squeezed near the ENG/MNG interface is demonstrated to be left-handed surface waves with backward phase velocity.Comment: 18 pages, 6 figure

The effectiveness of the creativity trigger module in achieving higher levels of creative thinking among prospective teachers

The unoptimised level of creative thinking is seen as an issue among Semester 8 prospective teachers in Malaysian Teacher-Education Institutes (IPG). This could impede their teaching of creative thinking as one of the four components of 21st century skills in schools. In relation to this, this study sets out to investigate prior creativity levels of IPG prospective teachers and develop the Creativity Trigger Module (CTM) as a training module for enhancing their creativity. The Torrance Tests of Creative Thinking (TTCT) was used to compare the prior creativity levels of four respondent groups and test the effectiveness of the CTM on five dimensions of figural creativity, namely fluency, originality, elaboration, resistance to premature closure, abstractness of titles, and their overall creativity. A two-stage cluster sampling technique identified two IPGs with 68 respondents in the state of Johor namely, IPG-Kampus Tun Hussein Onn, Batu Pahat (IPGKTHO) as the control group site (34 respondents), and IPG- Kampus Temenggong Ibrahim, Johor Bahru (IPGKTI) as the treatment group site (34 respondents). Mathematics (MT) and Design and Technology (RBT) are the only two specialist subject combinations that provided enough sample size at both test sites. A quasi-experimental research design was used and this involved intact classes. Data analysis was carried out as follows: ANOVA, ANCOVA, and Wilcoxon Signed Rank Test analysis for TTCT scores while data analysis based on the NVivo software was used for the focus group interviews. Findings on prior creativity levels showed average or low creativity levels among all 4 test groups with IPGKTHO and RBT options having significantly higher posttest marks as compared to IPGKTI and MT option respectively. The CTM was found to improve significantly respondents’ posttest marks for the treatment group in all the five dimensions of figural creativity and, their overall creativity. Feedback from respondents revealed positive support for the CTM. In conclusion, the prior creativity of IPG prospective teachers was at an unoptimised level before treatment but the CTM has been successfully developed as an effective resource for enhancing the creative thinking levels among IPG prospective teachers

Library Instruction and Themed Composition Courses: An Investigation of Factors that Impact Student Learning

Many academic libraries partner with English composition in order to teach first year students skills related to academic research and writing. Due to the partnership between information literacy and first-year writing programs, it is important to evaluate how these programs can best support one another. The purpose of this study was to examine the impact of two factors on student information literacy skill development: library instruction and section theme—defined here as class sections of the English 102 (ENG 102) program developed around a central topic selected by the instructor. A random sample of annotated bibliographies from 95 sections of ENG 102 were scored with two information literacy rubrics in order to find out if scores differed between sections based on the variables of library instruction and theme. The results of this study indicate that sections of the ENG 102 program that attended an information literacy instruction session scored significantly higher on the annotated bibliography assignment than sections that did not attend. We also found that themed sections of ENG 102 scored marginally higher on the annotated bibliography than non-themed sections of ENG 102. Implications for further research are discussed, including the potential impact of theme-based writing on information literacy learning

Site selection, structural design, construction, management and production of floating cage culture system in Malaysia

The success of cage culture system is largely determined by correct selection of favourable sites, suitable cage size and facilities and management of the system. These three elements are considered in this paper in relation to culture systems in Malaysia

Rogue NGOs and NPOs: content, context, consequences

This paper explores the key components of dysfunctional, criminal and deviant behaviours within and by associational and not-for-profit organisations, and their consequences in terms of practice, application and policy. Abstract This short primer explores the key components of dysfunctional, criminal and deviant behaviors within and by associational and not-for-profit organizations, and their consequences in terms of practice, application and policy. A rich literature review of major and minor nonprofit scandals—primarily in the West—but also in other countries around the world demonstrate the breadth and depth of nonprofit corruption, fraud and misuse of funds as well as misconduct and deviant behavior by individuals within and by organizations. These associations range from Mom and Pop-scaled voluntary foundations to transnational charitable organizations, and so-called “Dark Nonprofit Groups (DNGs)” that promote terrorism, hate, extreme political views and other noxious or bizarre ideologies. Summarized are the widely researched concerns regarding self-regulation of these organizations including weaknesses in management controls, issues with adherence to existing vision and mission statements; board and management accountability; internal and external fiduciary controls; and intra- and inter-governmental regulatory responses. The context of these wrongdoings are ensconced within the framework of a discussion of ethics, morals, and wayward interpretations of legal and ownership structures in prevailing cultures and societies. Consequences of nonprofit organizational misconduct and dysfunction reveal a universal need for more research into the dark side of the Third Sector; and additional accountability and transparency not only at the micro level—individuals and board members within the organization--but also at the state, federal and global level. Lastly, increasingly vocal activism of civil society is acknowledged to have given shape and direction to the new moral landscape of 21st century Third Sector agendas