Editorial: A Brief Retrospective (2013-2019)

In this editorial, we wish to offer: (1) some reflections on my experience as EIC—initially and as I got involved in the role, as well as after I retired from the role; (2) an overview of what JAIS published in the six years of my term—the credit for preparing this part of the article goes to my co-authors; and (3) heartfelt thanks to members of the community for supporting the journal and its EIC

Announcing the new EiC

As I mentioned in my last editorial, my term as editor-in-chief (EiC) of the magazine is coming to an end, and it is my great pleasure to announce that the new EiC of the magazine will be Dr. Peter Corke from CSIRO in Australia. I am extremely happy and comfortable to leave the magazine to Peter who is not only an extremely distinguished scientist but also a motivated leader and pleasant person who will take care with dedication to keep the high level of the magazine and further improve it

Editorial

oai:ojs.ojs.eahil.eu:article/19Dear EAHIL friends,I find myself very touched while writing this Editorial, not because I haven’t written for these pages before, but because it is the first time that I am addressing you all in my new role of Editor in Chief (EiC).....

p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans

Type II endometrial carcinomas are a highly aggressive group of tumour subtypes that are frequently associated with inactivation of the TP53 tumour suppressor gene. We show that mice with endometrium-specific deletion of Trp53 initially exhibited histological changes that are identical to known precursor lesions of type II endometrial carcinomas in humans and later developed carcinomas representing all type II subtypes. The mTORC1 signalling pathway was frequently activated in these precursor lesions and tumours, suggesting a genetic cooperation between this pathway and Trp53 deficiency in tumour initiation. Consistent with this idea, analyses of 521 human endometrial carcinomas identified frequent mTORC1 pathway activation in type I as well as type II endometrial carcinoma subtypes. mTORC1 pathway activation and p53 expression or mutation status each independently predicted poor patient survival. We suggest that molecular alterations in p53 and the mTORC1 pathway play different roles in the initiation of the different endometrial cancer subtypes, but that combined p53 inactivation and mTORC1 pathway activation are unifying pathogenic features among histologically diverse subtypes of late stage aggressive endometrial tumours

Exact Requirements Engineering for Developing Business Process Models

Process modeling is a suitable tool for improving the business processes. Successful process modeling strongly depends on correct requirements engineering. In this paper, we proposed a combination approach for requirements elicitation for developing business models. To do this, BORE (Business-Oriented Requirements Engineering) method is utilized as the base of our work and it is enriched by the important features of the BDD (Business-driven development) method, in order to make the proposed approach appropriate for modeling the more complex processes. As the main result, our method eventuates in exact requirements elicitation that adapts the customers' needs. Also, it let us avoid any rework in the modeling of process. In this paper, we conduct a case study for the paper submission and publication system of a journal. The results of this study not only give a good experience of real world application of proposed approach on a web-based system, also it approves the proficiency of this approach for modeling the complex systems with many sub-processes and complicated relationships.Comment: (IEEE) 3th International Conference on Web Researc

So long, farewell, auf wiedersehen, but not goodbye

This is my “so long, farewell, au Wiedersehen, but not goodbye” editorial letter to you, our authors and readers of the Malawi Medical Journal (MMJ). In July 2016, I assumed the role of the Editor-in-Chief (EiC) of the MMJ, Malawi’s only medical journal and, if you do not already know, one of the leading medical journals in sub-Saharan Africa. Just to put it into perspective for you, in 2016, the SCImago Institutions Rankings (SIR) placed the MMJ in 4th position in Africa for journals that publish in the field of medicine