102 research outputs found

    Unconstrained Ear Processing: What is Possible and What Must Be Done

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    Genetics and genomics of aortic form and function

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    The thoracic aorta is a dynamic organ which adapts and remodels throughout life. Thoracic aortic size, shape and function are important contributors to both cardiovascular health and disease and risk of aortic disease. A complex interaction of environmental, genetic and haemodynamic factors is mediated by cells of the aortic wall. This thesis presents aortic phenotyping, genotyping and genome-wide associations of aortic traits in a large healthy cohort of 1218 volunteers. This is the largest study to report normal parameters for healthy thoracic aortic size, shape and function derived from cardiovascular magnetic resonance imaging. Anthropometric and cardiovascular risk factors such as age, gender, body fat mass and lipid profile are identified as significant determinants of aortic phenotype. The work suggests that cardiovascular risk factors could impair normal adaptive aortic remodelling with age. Genome-wide association studies of aortic dimensions and function identify new common variants, genes and pathways which could be important in aortic biology and cardiovascular risk. These include genes involved in cardiovascular development (eg PCDH7 and SON associated with aortic root diameter), autonomic cardiovascular responses (eg GABA receptor genes associated with aortic root diameter), fibrosis (eg ACTC1, AGTR1 associated with ascending aortic distensibility, BAMBI and MYOD associated with descending aortic distensibility) and obesity (eg ARID5B and IRX3 associated with aortic pulse wave velocity and ascending aortic area respectively). Multiple regulatory pathways including TGF-ß and IGF signalling (IGF1R, IGF2R), are identified which are associated with aortic dimensions and function. Joint trait analysis of aortic root dimensions identifies a new genome-wide significant association with TENM4, a key driver of early mesodermal development, and suggestive association with PTN, which is functionally related and plays a key role in angiogenesis. The primary analyses are complemented by exploratory assessment of rare genetic variation in bicuspid aortic valve (BAV) using panel sequencing in 177 patients. Rare variants might cause, or modify phenotype in BAV, but the clinical utility of panel sequencing remains poor. A further complementary study investigates the interaction of haemodynamics with aortic cellular phenotype, using microarray assessment of aortic endothelial cell transcriptomic response to shear stress pattern. Several genes of interest in atherosclerosis and aortic disease are differentially expressed with shear stress pattern, such as FABP4, ANGPT2, FILIP1, KIT, DCHS1, TGFBR3 and LOX. This work yields new insights into aortic phenotype, identifies key loci which might determine aortic traits and explores the complex interdependence of genetics, haemodynamics and environmental variables in aortic biology.Open Acces

    Togo's Political and Socio-Economic Development (2019-2021) (author's extended and annotated version of BTI 2022 - Togo Country Report)

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    The GnassingbĂ© clan has ruled the country since 1967. The demand for political alternance, constituted the major contentious issue between the government and the challengers of the GnassingbĂ© regime throughout the survey period. The first local elections since more than 30 years took finally place on 30 June 2019 and resulted in the victory of the ruling party. Shortly afterwards, in February 2020, the President won also the disputed presidential elections and thus consolidated his power, assisted by the loyal army and security services. The outbreak of the Corona epidemic in Togo in April 2020 and the subsequent economic recession may have contributed to limit popular protest against the GnassingbĂ© regime. The human rights record of the government has improved but remains poor. Despite undeniable improvements to the framework and appearance of the regime's key institutions during the review period, democracy remains far from complete. However, the international community, notably Togo’s African peers, the AU and ECOWAS, followed a 'laissez-faire' approach in the interests of regional stability and their national interests in dealing with Togo. Economic growth remained stable at about 5% per annum (before Corona). Public investment in infrastructure and increases in agricultural productivity, notably of export crops, had been the key drivers of economic growth. However, growth remains vulnerable to external shocks and the climate and has not been inclusive. Moreover, it was overshadowed by increasing inter-personal and regional inequality as well as an increase in extreme poverty. Money-laundering, illegal money transfers and trafficking grew alarmingly. Nevertheless, the business climate improved considerably

    Privaatsust sÀilitava raalnÀgemise meetodi arendamine kehalise aktiivsuse automaatseks jÀlgimiseks koolis

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    VĂ€itekirja elektrooniline versioon ei sisalda publikatsiooneKuidas vaadelda inimesi ilma neid nĂ€gemata? Öeldakse, et ei ole viisakas jĂ”llitada. Õigus privaatsusele on lausa inimĂ”igus. Siiski on inimkĂ€itumises palju sellist, mida teadlased tahaksid uurida inimesi vaadeldes. NĂ€iteks tahame teada, kas lapsed hakkavad vahetunnis rohkem liikuma, kui koolis keelatakse nutitelefonid? Selle vĂ€lja selgitamiseks peaks teadlane kĂŒsima lapsevanematelt nĂ”usolekut vĂ”sukeste vaatlemiseks. Eeldusel, et lapsevanemad annavad loa, oleks klassikaliseks vaatluseks vaja tohutult palju tööjĂ”udu – mitu vaatlejat koolimajas iga pĂ€ev piisavalt pikal perioodil enne ja pĂ€rast nutitelefoni keelu kehtestamist. Doktoritööga pĂŒĂŒdsin lahendada korraga privaatsuse probleemi ja tööjĂ”u probleemi, asendades inimvaatleja tehisaruga. Kaasaegsed masinĂ”ppe meetodid vĂ”imaldavad luua mudeleid, mis tuvastavad automaatselt pildil vĂ”i videos kujutatud objekte ja nende omadusi. Kui tahame tehisaru, mis tunneb pildil Ă€ra inimese, tuleb moodustada masinĂ”ppe andmestik, kus on pilte inimestest ja pilte ilma inimesteta. Kui tahame tehisaru, mis eristaks videos madalat ja kĂ”rget kehalist aktiivsust, on vaja vastavat videoandmestikku. Doktoritöös kogusingi andmestiku, kus video laste liikumisest on sĂŒnkroniseeritud puusal kantavate aktseleromeetritega, et treenida mudel, mis eristaks videopikslites madalamat ja kĂ”rgemat liikumise intensiivsust. Koostöös Tehonoloogiainstituudi iCV laboriga arendasime vĂ€lja videoanalĂŒĂŒsi sensori prototĂŒĂŒbi, mis suudab reaalaja kiirusel hinnata kaamera vaatevĂ€ljas olevate inimeste kehalise aktiivsuse taset. Just see, et tehisaru suudab tuletada videost kehalise aktiivsuse informatsiooni ilma neid videokaadreid salvestamata ega inimestele ĂŒldsegi nĂ€itamata, vĂ”imaldab vaadelda inimesi ilma neid nĂ€gemata. VĂ€ljatöötatud meetod on mĂ”eldud kehalise aktiivsuse mÔÔtmiseks koolipĂ”histes teadusuuringutes ning seetĂ”ttu on arenduses rĂ”hutatud privaatsuse kaitsmist ja teaduseetikat. Laiemalt vaadates illustreerib doktoritöö aga raalnĂ€gemistehnoloogiate potentsiaali töötlemaks visuaalset infot linnaruumis ja töökohtadel ning mitte ainult kehalise aktiivsuse mÔÔtmiseks kĂ”rgete teaduseetika kriteerimitega. Siin ongi koht avalikuks aruteluks – millistel tingimustel vĂ”i kas ĂŒldse on OK, kui sind jĂ”llitab robot?  How to observe people without seeing them? They say it's not polite to stare. The right to privacy is considered a human right. However, there is much in human behavior that scientists would like to study via observation. For example, we want to know whether children will start moving more during recess if smartphones are banned at school? To figure this out, scientists would have to ask parental consent to carry out the observation. Assuming parents grant permission, a huge amount of labour would be needed for classical observation - several observers in the schoolhouse every day for a sufficiently long period before and after the smartphone ban. With my doctoral thesis, I tried to solve both the problem of privacy and of labor by replacing the human observer with artificial intelligence (AI). Modern machine learning methods allow training models that automatically detect objects and their properties in images or video. If we want an AI that recognizes people in images, we need to form a machine learning dataset with pictures of people and pictures without people. If we want an AI that differentiates between low and high physical activity in video, we need a corresponding video dataset. In my doctoral thesis, I collected a dataset where video of children's movement is synchronized with hip-worn accelerometers to train a model that could differentiate between lower and higher levels of physical activity in video. In collaboration with the ICV lab at the Institute of Technology, we developed a prototype video analysis sensor that can estimate the level of physical activity of people in the camera's field of view at real-time speed. The fact that AI can derive information about physical activity from the video without recording the footage or showing it to anyone at all, makes it possible to observe without seeing. The method is designed for measuring physical activity in school-based research and therefore highly prioritizes privacy protection and research ethics. But more broadly, the thesis illustrates the potential of computer vision technologies for processing visual information in urban spaces and workplaces, and not only for measuring physical activity or adhering to high ethical standards. This warrants wider public discussion – under what conditions or whether at all is it OK to have a robot staring at you?https://www.ester.ee/record=b555972
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