Developing Robust Models, Algorithms, Databases and Tools With Applications to Cybersecurity and Healthcare

As society and technology becomes increasingly interconnected, so does the threat landscape. Once isolated threats now pose serious concerns to highly interdependent systems, highlighting the fundamental need for robust machine learning. This dissertation contributes novel tools, algorithms, databases, and models—through the lens of robust machine learning—in a research effort to solve large-scale societal problems affecting millions of people in the areas of cybersecurity and healthcare. (1) Tools: We develop TIGER, the first comprehensive graph robustness toolbox; and our ROBUSTNESS SURVEY identifies critical yet missing areas of graph robustness research. (2) Algorithms: Our survey and toolbox reveal existing work has overlooked lateral attacks on computer authentication networks. We develop D2M, the first algorithmic framework to quantify and mitigate network vulnerability to lateral attacks by modeling lateral attack movement from a graph theoretic perspective. (3) Databases: To prevent lateral attacks altogether, we develop MALNET-GRAPH, the world’s largest cybersecurity graph database—containing over 1.2M graphs across 696 classes—and show the first large-scale results demonstrating the effectiveness of malware detection through a graph medium. We extend MALNET-GRAPH by constructing the largest binary-image cybersecurity database—containing 1.2M images, 133×more images than the only other public database—enabling new discoveries in malware detection and classification research restricted to a few industry labs (MALNET-IMAGE). (4) Models: To protect systems from adversarial attacks, we develop UNMASK, the first model that flags semantic incoherence in computer vision systems, which detects up to 96.75% of attacks, and defends the model by correctly classifying up to 93% of attacks. Inspired by UNMASK’s ability to protect computer visions systems from adversarial attack, we develop REST, which creates noise robust models through a novel combination of adversarial training, spectral regularization, and sparsity regularization. In the presence of noise, our method improves state-of-the-art sleep stage scoring by 71%—allowing us to diagnose sleep disorders earlier on and in the home environment—while using 19× less parameters and 15×less MFLOPS. Our work has made significant impact to industry and society: the UNMASK framework laid the foundation for a multi-million dollar DARPA GARD award; the TIGER toolbox for graph robustness analysis is a part of the Nvidia Data Science Teaching Kit, available to educators around the world; we released MALNET, the world’s largest graph classification database with 1.2M graphs; and the D2M framework has had major impact to Microsoft products, inspiring changes to the product’s approach to lateral attack detection.Ph.D

Front-Line Physicians' Satisfaction with Information Systems in Hospitals

Day-to-day operations management in hospital units is difficult due to continuously varying situations, several actors involved and a vast number of information systems in use. The aim of this study was to describe front-line physicians' satisfaction with existing information systems needed to support the day-to-day operations management in hospitals. A cross-sectional survey was used and data chosen with stratified random sampling were collected in nine hospitals. Data were analyzed with descriptive and inferential statistical methods. The response rate was 65 % (n = 111). The physicians reported that information systems support their decision making to some extent, but they do not improve access to information nor are they tailored for physicians. The respondents also reported that they need to use several information systems to support decision making and that they would prefer one information system to access important information. Improved information access would better support physicians' decision making and has the potential to improve the quality of decisions and speed up the decision making process.Peer reviewe

Complex Adaptive Systems & Urban Morphogenesis:

This thesis looks at how cities operate as Complex Adaptive Systems (CAS). It focuses on how certain characteristics of urban form can support an urban environment's capacity to self-organize, enabling emergent features to appear that, while unplanned, remain highly functional. The research is predicated on the notion that CAS processes operate across diverse domains: that they are ‘generalized' or ‘universal'. The goal of the dissertation is then to determine how such generalized principles might ‘play out' within the urban fabric. The main thrust of the work is to unpack how elements of the urban fabric might be considered as elements of a complex system and then identify how one might design these elements in a more deliberate manner, such that they hold a greater embedded capacity to respond to changing urban forces. The research is further predicated on the notion that, while such responses are both imbricated with, and stewarded by human actors, the specificities of the material characteristics themselves matter. Some forms of material environments hold greater intrinsic physical capacities (or affordances) to enact the kinds of dynamic processes observed in complex systems than others (and can, therefore, be designed with these affordances in mind). The primary research question is thus:   What physical and morphological conditions need to be in place within an urban environment in order for Complex Adaptive Systems dynamics arise - such that the physical components (or ‘building blocks') of the urban environment have an enhanced capacity to discover functional configurations in space and time as a response to unfolding contextual conditions?   To answer this question, the dissertation unfolds in a series of parts. It begins by attempting to distill the fundamental dynamics of a Complex Adaptive System. It does so by means of an extensive literature review that examines a variety of highly cited ‘defining principles' or ‘key attributes' of CAS. These are cross-referenced so as to extract common features and distilled down into six major principles that are considered as the generalized features of any complex system, regardless of domain. In addition, this section considers previous urban research that engages complexity principles in order to better position the distinctive perspective of this thesis. This rests primarily on the dissertation's focus on complex urban processes that occur by means of materially enabled in situ processes. Such processes have, it is argued, remained largely under-theorized. The opening section presents introductory examples of what might be meant by a ‘materially enabling' environment.   The core section of the research then undertakes a more detailed unpacking of how complex processes can be understood as having a morphological dimension. This section begins by discussing, in broad terms, the potential ‘phase space' of a physical environment and how this can be expanded or limited according to a variety of factors. Drawing insights from related inquiries in the field of Evolutionary Economic Geography, the research argues that, while emergent capacity is often explored in social, economic, or political terms, it is under-theorized in terms of the concrete physical sub-strata that can also act to ‘carry' or ‘moor' CAS dynamics. This theme is advanced in the next article, where a general framework for speaking about CAS within urban environments is introduced. This framework borrows from the terms for ‘imageability' that were popularized by Kevin Lynch: paths, edges, districts, landmarks, and nodes. These terms are typically associated with physical or ‘object-like features' of the urban environment – that is to say, their image. The terminology is then co-opted such that it makes reference not simply to physical attributes, but rather to the complex processes these attributes enable. To advance this argument, the article contrasts the static and ‘imageable' qualities of New Urbanism projects with the ‘unfolding' and dynamic qualities of complex systems - critiquing NU proponents as failing to appreciate the underlying forces that generate the environments they wish to emulate. Following this, the efficacy of the re-purposed ‘Lynchian' framework is tested using the case study of Istanbul's Grand Bazaar. Here, specific elements of the Bazaar's urban fabric are positioned as holding material agency that enables particular emergent spatial phenomena to manifest. In addition, comparisons are drawn between physical dynamics unfolding within the Bazaar's morphological setting (leading to emergent merchant districts) and parallel dynamics explored within Evolutionary Economic Geography).   The last section of the research extends this research to consider digitally augmented urban elements that hold an enhanced ability to receive and convey information. A series of speculative thought-experiments highlight how augmented urban entities could employ CAS dynamics to ‘solve for' different kinds of urban optimization scenarios, leading these material entities to self-organize (with their users) and discover fit regimes. The final paper flips the perspective, considering how, not only material agency, but also human agency is being augmented by new information processing technologies (smartphones), and how this can lead to new dances of agency that in turn generate novel emergent outcomes.   The dissertation is based on a compilation of articles that have, for the most part, been published in academic journals and all the research has been presented at peer-reviewed academic conferences. An introduction, conclusion, and explanatory transitions between sections are provided in order to clarify the narrative thread between the sections and the articles. Finally, a brief ‘coda' on the spatial dynamics afforded by Turkish Tea Gardens is offered