A Tissue Engineering product development pathway

Tissue engineering is a field of inquiry and research that uses engineering techniques and principles of biological sciences to develop functional substitutes for reconstruction of damaged organs. Commercial translation of tissue engineering products is currently in progress all over the world. Many companies are moving their interest towards this market segment that grows by 6% per year. Aim of this thesis is to probe the possibility of developing tissue engineering products in the most cost-effective way, minimizing the industrial risk and developing a specific fund raising model. Tissue engineering is based on three main features: cells, scaffolds and bioreactors. Cells are seeded on a scaffold and cultured in a bioreactor in order to obtain a tissue engineering product. Nevertheless, developing cell carrying products is hampered by certification claims ("advanced therapies" certification rules) that unbearably increase R&D and certification costs and can be faced by either big companies or start-ups of big companies and spin-offs of complex aggregates of research centers involved in advanced cell research. On the other hand, scaffolds (certification class IIb) and bioreactors for tissue engineering (certification class I) can be developed with a lower economic effort, being the competition based on innovation, since their market is in the "growth phase" for scaffolds and in the "introduction phase" for bioreactors in the Levitt's product life cycle theory. Purpose of this thesis is to basically study scaffold and bioreactor features, then to preliminarily design some models of bioreactors and, eventually, to set a business model, based on private and public fund raising, aimed to the development of scaffolds for dental implantology and of bioreactors for cardiovascular and bone tissue engineering. Finally, a business plan of a company being spin-off of Politecnico di Torino and industrial start-up has been elaborate

Managing engineering design in complex supply chains

The trend towards organising design, development and manufacture via supply chains, rather than predominantly in-house, poses major challenges for design management. Procurement methods based on adversarial competitive tendering are generally unsuited to complex engineering products requiring strong design and development coordination. Literature on ‘supplier partnerships’ has largely overlooked the implications for managing design and development. This paper reports the results of a major project that focuses upon this issue, concentrating on practical case studies – from British Rail, Netherlands Railways, Rolls Royce and British Coal – that involve the management of ‘devolved’ engineering design by large business organisations. A spectrum of approaches from in-house to fully devolved design is described. It is concluded that there does not appear to be a single best approach for managing devolved design, but that appropriate approaches for an organisation depend on its location in the supply chain and its ability to manage organisational change

Risk assessment and relationship management: practical approach to supply chain risk management

The literature suggests the need for incorporating the risk construct into the measurement of organisational performance, although few examples are available as to how this might be undertaken in relation to supply chains. A conceptual framework for the development of performance and risk management within the supply chain is evolved from the literature and empirical evidence. The twin levels of dyadic performance/risk management and the management of a portfolio of performance/risks is addressed, employing Agency Theory to guide the analysis. The empirical evidence relates to the downstream management of dealerships by a large multinational organisation. Propositions are derived from the analysis relating to the issues and mechanisms that may be employed to effectively manage a portfolio of supply chain performance and risks

Trade Collapse, Trade Relapse and Global Production Networks: Supply Chains in the Great Recession

Global supply chains reshaped international trade since the end 1980s. Their role in explaining the trade collapse that followed the financial crisis of September 2008 was determinant. Because production is internationally diversified, adverse external shocks affect firms not only through final demand, but also through a rupture in the flow of inputs received from their suppliers. The future of supply chain will also determine the alternative exit scenarios from the Great Recession; as a result of global rebalancing, they will probably be smaller and more regional. Left unchecked, these centripetal forces may lead to a deterioration of global governance and to deglobalization. The reshaping of global effective demand is of particular importance for the labour abundant lesser advanced developing countries that where relying on the strength of the global supply chains to attract productive investments. On the other hand, because trade in goods for processing inflated artificially some bilateral trade deficit, rebalancing them will prove easier in the short term, while the technical factors that made possible the internationalization of production will still promote further "flattening of the Earth" in the longer terminternational trade; crisis; global supply chains; transmission channels; global rebalancing; trade and development

Instruments to support decision competencies of an investment project manager

From among many competencies of a manager, the abilities of team, project and organization management become especially important. However, to make right decisions, one needs to have appropriate tools supporting effective company management. In case of companies carrying out investment, modernization or innovative projects, it is especially important. Implementation of those projects takes place in various conditions resulting from changing and turbulent environment. Thus, if the manager does not have sufficient information support, provided in time and allowing for effective decision making, which mitigates negative effects of previous actions, he is basically doomed to failure. In such a case, what decides about the situation in the project execution process is a coincidence, not intentional actions of the staff, based on their knowledge about potential risks. Such a knowledge, gained early enough, allows for taking more effective corrective actions. This paper is an attempt to define an operational model of a company along with principles of monitoring actions of an enterprise that carries out projects and functions in the current economic situation, illustrated by an example of a construction company. Its implementation is supposed to provide the managing staff with stores of information that efficiently support the company management process

The strategic importance of supply chains and the RFID radio data identification system

Purpose: The paper presents the issues related to the process of supply chain management. It presents the essence and classification of supply chains and the interpretation of global supply network management. Design/Methodology/Approach: Using systems theory as a basis, a RFID utilization and outcome(s) performance model was developed from the literature. The study uses surveys conducted among twenty companies in the 2016-2017 research year. Enterprises that use RFID technologies in the supply chain were analyzed. Findings: The Findings indicate that application of RFID technology leads to improved manufacturing efficiency and manufacturing effectiveness, while improvement in efficiency lead directly to improved organizational performance, and improvements in effectiveness lead directly to improved supply chain performance. Practical Implications: Certain policy implications and obligations accrue are companies that use RFID technology in their supply order to manage the company more efficiently. Originality/Value: The publication presents the results of research carried out in enterprises using the new RFID system as a modern technique of supporting supply chain management to increase the efficiency of cooperation throughout the entire supply chain.peer-reviewe

National strategies for technology adoption in the industrial sector: Lessons of recent experience in the developing regions

human development, technology