Holonic multi-agent system complemented by human disease ontology supporting bio-medical community

The medical milieu is an open environment characterized by a variety of distributed, heterogeneous and autonomous information resources. Coordination, cooperation and exchange of information are important to the medical community. This paper presents an Ontology-based Holonic Multiagent System that combines the advantages of the holonic paradigm with multi-agent system technology and ontology design, in order to realize a highly reliable, adaptive, scalable, flexible and robust diagnostic system for diseases. We design a new ontology, called Generic Human Disease Ontology (GHDO), for the representation of knowledge regarding human diseases. The concepts of the GHDO ontology are organized into the following four dimensions: Types, Symptoms, Causes and Treatments of human diseases. The holonic multi-agent system uses this common GHDO ontology for purpose of query formulation, information retrieval and information integration. This intelligent dynamic system provides opportunities to collect information from multiple information resources, to share data efficiently and to integrate and manage scientific results in a timely manner. We believe such a technique is expected to become the norm once existing resources (e.g. disease databases) will have become unlocked semantically through annotation with a shared ontology

Context-Aware Information Retrieval for Enhanced Situation Awareness

In the coalition forces, users are increasingly challenged with the issues of information overload and correlation of information from heterogeneous sources. Users might need different pieces of information, ranging from information about a single building, to the resolution strategy of a global conflict. Sometimes, the time, location and past history of information access can also shape the information needs of users. Information systems need to help users pull together data from disparate sources according to their expressed needs (as represented by system queries), as well as less specific criteria. Information consumers have varying roles, tasks/missions, goals and agendas, knowledge and background, and personal preferences. These factors can be used to shape both the execution of user queries and the form in which retrieved information is packaged. However, full automation of this daunting information aggregation and customization task is not possible with existing approaches. In this paper we present an infrastructure for context-aware information retrieval to enhance situation awareness. The infrastructure provides each user with a customized, mission-oriented system that gives access to the right information from heterogeneous sources in the context of a particular task, plan and/or mission. The approach lays on five intertwined fundamental concepts, namely Workflow, Context, Ontology, Profile and Information Aggregation. The exploitation of this knowledge, using appropriate domain ontologies, will make it feasible to provide contextual assistance in various ways to the work performed according to a user’s taskrelevant information requirements. This paper formalizes these concepts and their interrelationships

Is a Semantic Web Agent a Knowledge-Savvy Agent?

The issue of knowledge sharing has permeated the field of distributed AI and in particular, its successor, multiagent systems. Through the years, many research and engineering efforts have tackled the problem of encoding and sharing knowledge without the need for a single, centralized knowledge base. However, the emergence of modern computing paradigms such as distributed, open systems have highlighted the importance of sharing distributed and heterogeneous knowledge at a larger scale—possibly at the scale of the Internet. The very characteristics that define the Semantic Web—that is, dynamic, distributed, incomplete, and uncertain knowledge—suggest the need for autonomy in distributed software systems. Semantic Web research promises more than mere management of ontologies and data through the definition of machine-understandable languages. The openness and decentralization introduced by multiagent systems and service-oriented architectures give rise to new knowledge management models, for which we can’t make a priori assumptions about the type of interaction an agent or a service may be engaged in, and likewise about the message protocols and vocabulary used. We therefore discuss the problem of knowledge management for open multi-agent systems, and highlight a number of challenges relating to the exchange and evolution of knowledge in open environments, which pertinent to both the Semantic Web and Multi Agent System communities alike

Ontology acquisition and exchange of evolutionary product-brokering agents

Agent-based electronic commerce (e-commerce) has been booming with the development of the Internet and agent technologies. However, little effort has been devoted to exploring the learning and evolving capabilities of software agents. This paper addresses issues of evolving software agents in e-commerce applications. An agent structure with evolution features is proposed with a focus on internal hierarchical knowledge. We argue that knowledge base of agents should be the cornerstone for their evolution capabilities, and agents can enhance their knowledge bases by exchanging knowledge with other agents. In this paper, product ontology is chosen as an instance of knowledge base. We propose a new approach to facilitate ontology exchange among e-commerce agents. The ontology exchange model and its formalities are elaborated. Product-brokering agents have been designed and implemented, which accomplish the ontology exchange process from request to integration

Coordination approaches and systems - part I : a strategic perspective

This is the first part of a two-part paper presenting a fundamental review and summary of research of design coordination and cooperation technologies. The theme of this review is aimed at the research conducted within the decision management aspect of design coordination. The focus is therefore on the strategies involved in making decisions and how these strategies are used to satisfy design requirements. The paper reviews research within collaborative and coordinated design, project and workflow management, and, task and organization models. The research reviewed has attempted to identify fundamental coordination mechanisms from different domains, however it is concluded that domain independent mechanisms need to be augmented with domain specific mechanisms to facilitate coordination. Part II is a review of design coordination from an operational perspective

Agents in Bioinformatics

The scope of the Technical Forum Group (TFG) on Agents in Bioinformatics (BIOAGENTS) was to inspire collaboration between the agent and bioinformatics communities with the aim of creating an opportunity to propose a different (agent-based) approach to the development of computational frameworks both for data analysis in bioinformatics and for system modelling in computational biology. During the day, the participants examined the future of research on agents in bioinformatics primarily through 12 invited talks selected to cover the most relevant topics. From the discussions, it became clear that there are many perspectives to the field, ranging from bio-conceptual languages for agent-based simulation, to the definition of bio-ontology-based declarative languages for use by information agents, and to the use of Grid agents, each of which requires further exploration. The interactions between participants encouraged the development of applications that describe a way of creating agent-based simulation models of biological systems, starting from an hypothesis and inferring new knowledge (or relations) by mining and analysing the huge amount of public biological data. In this report we summarise and reflect on the presentations and discussions