Differential recruitment of brain networks following route and cartographic map learning of spatial environments.

An extensive neuroimaging literature has helped characterize the brain regions involved in navigating a spatial environment. Far less is known, however, about the brain networks involved when learning a spatial layout from a cartographic map. To compare the two means of acquiring a spatial representation, participants learned spatial environments either by directly navigating them or learning them from an aerial-view map. While undergoing functional magnetic resonance imaging (fMRI), participants then performed two different tasks to assess knowledge of the spatial environment: a scene and orientation dependent perceptual (SOP) pointing task and a judgment of relative direction (JRD) of landmarks pointing task. We found three brain regions showing significant effects of route vs. map learning during the two tasks. Parahippocampal and retrosplenial cortex showed greater activation following route compared to map learning during the JRD but not SOP task while inferior frontal gyrus showed greater activation following map compared to route learning during the SOP but not JRD task. We interpret our results to suggest that parahippocampal and retrosplenial cortex were involved in translating scene and orientation dependent coordinate information acquired during route learning to a landmark-referenced representation while inferior frontal gyrus played a role in converting primarily landmark-referenced coordinates acquired during map learning to a scene and orientation dependent coordinate system. Together, our results provide novel insight into the different brain networks underlying spatial representations formed during navigation vs. cartographic map learning and provide additional constraints on theoretical models of the neural basis of human spatial representation

Understanding Complex Systems: From Networks to Optimal Higher-Order Models

To better understand the structure and function of complex systems, researchers often represent direct interactions between components in complex systems with networks, assuming that indirect influence between distant components can be modelled by paths. Such network models assume that actual paths are memoryless. That is, the way a path continues as it passes through a node does not depend on where it came from. Recent studies of data on actual paths in complex systems question this assumption and instead indicate that memory in paths does have considerable impact on central methods in network science. A growing research community working with so-called higher-order network models addresses this issue, seeking to take advantage of information that conventional network representations disregard. Here we summarise the progress in this area and outline remaining challenges calling for more research.Comment: 8 pages, 4 figure