Review on Master Patient Index

In today's health care establishments there is a great diversity of information systems. Each with different specificities and capacities, proprietary communication methods, and hardly allow scalability. This set of characteristics hinders the interoperability of all these systems, in the search for the good of the patient. It is vulgar that, when we look at all the databases of each of these information systems, we come across different registers that refer to the same person; records with insufficient data; records with erroneous data due to errors or misunderstandings when inserting patient data; and records with outdated data. These problems cause duplicity, incoherence, discontinuation and dispersion in patient data. With the intention of minimizing these problems that the concept of a Master Patient Index is necessary. A Master Patient Index proposes a centralized repository, which indexes all patient records of a given set of information systems. Which is composed of a set of demographic data sufficient to unambiguously identify a person and a list of identifiers that identify the various records that the patient has in the repositories of each information system. This solution allows for synchronization between all the actors, minimizing incoherence, out datedness, lack of data, and a decrease in duplicate registrations. The Master Patient Index is an asset to patients, the medical staff and health care providers

Evaluation of Two Malaria Rapid Diagnostic Tests Quality Assurance (mRDT’s QA) Methods in Peripheral Health Facilities, Rural Tanzania.

\ud WHO recommends confirming suspected malaria cases before initiation of treatment. Due to the imited availability of quality microscopy services, this recommendation has been followed with increased use of antigen-detecting malaria rapid diagnostic tests (mRDTs) in many malaria endemic countries. With the increased use of mRDTs, the need for a thorough mRDT quality assurance (RDT QA) method has become more apparent. One of the WHO recommendations for RDT QA is to monitor the tests in field use monthly, by comparing mRDT results to reference microscopy. This study was carried out to monitor mRDT performance in selected health facilities using two quality assurance methods; first based on ference microscopy and second based on detection of parasite DNA by real time quantitative PCR (qPCR) on dried blood spots (DBS); as well as assessing the cost and timeliness of the two QA methods. Blood samples were collected from patients undergoing a rapid test for malaria for two to three consecutive days per month, for five months, in 12 health facilities in Iringa rural and Mufindi districts. The health workers were instructed to label RDT cassettes, blood smear slides, and filter papers for DBS with matching unique ID stickers. A sticker was also placed in the log book where RDT results were recorded. Blood smears (BS) were first read at the district hospital (BS1) and then transported to Bagamoyo for a reference reading at the IHI- Bagamoyo laboratory (BS2). A third BS reader (BS3) was consulted from Muhimbili University of Health and Allied Sciences (MUHAS) in case of discordant results between BS1 and BS2. Molecular analysis involved extraction of parasite DNA from DBS samples using a QIAamp DNA Mini Kit. Sample DNA aliquots were compared against standard solutions with parasite DNA diluted 10-fold to give a parasitemia ranging from 200,000/μL to 20/μL. About 20% of the study DNA aliquots were sent to the CDC laboratory in Atlanta in order to validate qPCR results performed at the Bagamoyo laboratory. Data were entered in Microsoft Access (Microsoft Corporation, 2006) and analyzed in STATA 10 (StataCorp, Texas USA). Because of the known limitations of mRDTs to detect parasitemia below 200 parasites/μL, BS and PCR results greater than or equal to 5 parasites/200 WBC or 200 parasites/μL were considered positive in comparisons with mRDT performance. In the univariate analysis, proportions of positive tests were compared among the three types of tests: mRDT, microscopy and qPCR. Microscopy readings were categorized into 3 groups; BS1, BS2 and /or BS summary which is an average of BS1 and BS2. In case of discordant results between BS1 and BS2, a third reader- BS3 was consulted. Chi-squared test was done to assess differences in proportion of positive tests per district; whereas McNemar’s test was Malaria RDT QA Final Report, March 2012 5 used to assess the difference in test positivity by type of test. Kappa statistic was used to quantify the strength of the agreement between tests results. In addition, we examined health workers performance of the testing procedure when attending patients at a health facility, using a predefined checklist. Towards the end of the study, an evaluation of health worker acceptability was carried out to assess preferences between the two RDT QA methods. We received 2369 samples and 2324 (98%) had complete information. mRDTs had the highest positivity rate (6.5%). The proportion of positive tests by all types of tests was slightly higher in Iringa DC, but only qPCR and BS2 showed statistically significant differences in positivity rate between the two districts, where Iringa DC had more positive tests than Mufindi DC (p<0.05). When qPCR was a gold standard, mRDTs had higher sensitivity (68.6%, 95%CI: 55.0-79.7) than microscopy (53.7%, 95%CI: 38.7- 68.0) but highest mRDT sensitivity was achieved with comparison to microscopy (85.3%, 95%CI: 70.0- 93.6). All tests had higher inter-observer agreement than would be expected by chance. Substantial high inter-observer agreement (kappa =0.75; p<0.001) was seen amongst the microscopists i.e. district’s quality assurance officers and the reference microscopy readings. Assessment of the time needed to process BS at the district level revealed that, smears at district level took on average 8 days (min 2 to max 33) to be processed and provide feedback; but up to an average of 44 days (min 19 to max 98) to get a second reading. Many health workers were aware that the use of mRDTs was due to changes in treatment policy (11/30), and patients who qualify for the test are those suspected to have malaria. Majority (16/30) related assessment of control line as a measure of test accuracy and suggested the use of microscopy for quality control of mRDT results (15/30). Their major concerns were mRDTs’ inability to give parasite count, stock-out of the tests kits in their working areas and the frequency of negative results. This evaluation encountered several challenges, among them were 1. Poor quality of blood smears made at health facilities, especially dispensaries, which do not have laboratory services. 2. About 3.5% of BS1 slides could not be processed for BS2 because they were damaged during transportation and/or poor quality of smears. This accounts for the small difference in the numbers of BS assessed between two readers. 3. We were not able to prepare standard concentration solutions for qPCR analysis in the country. 4. Problems with PCR machine and inability to repair it that necessitated shipment of the machine, to and from, the manufacturers in Europe (Germany). Malaria RDT QA Final Report, March 2012 6 Due to these challenges, qPCR results were not available until after specimen collection had ended. In this study malaria positivity was higher with mRDTs than microscopy and qPCR for the 200 parasites/μL lower boundary of positivity threshold. This could either be due to the strict lower cut-off point for microscopy and qPCR parasite density or higher false positivity of mRDTs due to persistent antigen in blood, errors in mRDTs performance or other patient’s characteristics. When qPCR was taken as gold standard, mRDTs showed better sensitivity than microscopy, but when microscopy was regarded as a gold standard, mRDTs showed higher sensitivity than with qPCR. However, results of qPCR demonstrated a better correlation (inter-observer agreement) with those of microscopy than with mRDTs. The challenges of performing qPCR, as observed in this evaluation, make it unsuitable for quality assurance of mRDTs in routine care, Tanzania. The high inter-observer agreement between districts’ and reference microscopists (K=0.75) and higher tests performances of BS1 when BS2 was a comparator, demonstrates the competence shown by district’s technicians/ technologists to suffice their involvement as reference microscopists for quality assurance of mRDTs in their respective districts. This is also complimented by a fact that, both BS1 and BS2 had more similar performance when qPCR was taken as a gold standard. In this setting, a microscopy-based quality assurance system to assess mRDT performance in routine use may be a practical and suitable method. However, long distance transportation of smears should be avoided.\u

Building evidence for improving childhood immunisation coverage in Africa.

Includes abstract.Includes bibliographical references.The Expanded Programme on Immunisation has the potential to substantially reduce child mortality and contribute to achieving the Millennium Development Goals. We assessed the programme’s performance in Africa, the reasons for poor performance, and effective interventions for improving its performance on the continent. We used a combination of methods including systematic reviews, bibliometric analyses, generalised linear models, and grading of the quality of evidence. We found that African countries have made extraordinary advances since childhood immunisation programmes began in 1974. However, there exist wide inter-country and intra-country differences, and the quality of immunisation data is poor. Besides, vaccines are administered well after the recommended ages in many countries; leaving children exposed to deadly vaccine-preventable diseases for long periods. In addition, Africa’s contribution to the global immunisation research output is minimal. There is no association between research productivity and immunisation coverage in Africa, which may signal lack of interactive communication between policymakers and researchers. Furthermore, individual and contextual factors (defined at community and country levels) are independently associated with low immunisation coverage; suggesting that immunisation system strengthening should address people and the communities and societies in which they live. Lastly, we found moderate-to-high quality evidence that interactive educational meetings, audit and feedback, supportive supervision; and use of community health workers, parent reminders, home visits, interactive communication, mass media, and material incentives have the potential to improve childhood immunisation coverage in Africa

Prevalence of HIV infection and median CD4 counts among health care workers in South Africa

Objective. To determine the prevalence of HIV infection and the extent of  disease progression based on CD4 count in a public health system workforce in southern Africa.Design. Cross-sectional voluntary, anonymous, unlinked survey including an oral fluid or blood sample and a brief demographic questionnaire.Setting. Two public hospitals in Gauteng, South Africa.SubJects. All 2 032 professional and support staff employed by the two hospitals.Outcome measures. HIV prevalence and CD4 cell count distribution.Results. Overall prevalence of HIV was 11.5%. By occupation, prevalence was highest among student nurses (13.8%) and nurses (13.7%). The  highest prevalence by age was in the 25- 34-year group (15.9%). Nineteen per cent of HIV-positive participants who provided blood samples had CD4  counts less than or equal to 200 cells/µl, 28% had counts 201 - 350  cells/pi, 18% had counts 351 - 500 cells/µl, and 35% had counts above 500 cells /µl.Conclusions. One out of 7 nurses and nursing students in this public sector workforce was HIV-positive. A high proportion of health care workers had CD4 counts below 350 cells/µl, and many were already eligible for  antiretroviral therapy under South African treatment guidelines. Given the short supply of nurses in South Africa, knowledge of prevalence in this workforce and provision of effective AIDS treatment are crucial for meeting future staffing needs

Impact of COVID-19 on clinical trials and clinical research: A systematic review

Background: The World Health Organization has reported more than 31,186,000 confirmed cases of coronavirus disease-19 (COVID-19), including 962,343 deaths, worldwide as on September 21, 2020. The current COVID-19 pandemic is affecting clinical research activities in most parts of the world. The focus on developing a vaccine for SARS-CoV-2 and the treatment of COVID-19 is, in fact, disrupting many upcoming and/or ongoing clinical trials on other diseases around the globe. On March 18, 2020, the United States Food and Drug Administration (FDA) issued an updated guideline for the conduct of clinical trials during the current health emergency situation. The potential challenges, such as social distancing and quarantines, result in study participants’ inaccessibility and trial personnel for in-person scheduled study visits and/or follow-up. Due to the sudden onset and wide-spread impact of COVID-19, its influence on the management of clinical trials and research necessitates urgent attention. Therefore, our systematic review of the literature aims to assess the impact of the COVID-19 pandemic on the conduction of clinical trials and research. The search for the relevant articles for review included the keywords "COVID-19” AND "clinical trial" in PubMed, MEDLINE, Embase, Google scholar and Google electronic databases. Key findings include: delaying subject enrollment and operational gaps in most ongoing clinical trials, which in turn has a negative impact on trial programmes and data integrity. Globally, most sites conducting clinical trials other than COVID-19 are experiencing a delay in timelines and a complete halt of operations in lieu of this pandemic, thus affecting clinical research outcomes

The Role Of EI In Effective Leadership, In The Context Of Saudi Arab: A Systematic Review

Background: The field of Emotional Intelligence (EI) is a growing field reflecting its effectiveness in different professions and institutes. There is little evidence available to seek a comprehensive role of EI in effective leadership. This study explores the role of EI in effective leadership. Aim: The aim of this study is to investigate how the component of EI plays an effective role in leadership, in the context of Saudi Arab. Method: For the purpose, a systematic approach was employed to identify and select relevant studies from key databases. Inclusion and exclusion criteria ensured the consideration of studies published within 05 years that examined the role of EI for effective leadership. Data extraction and analysis were conducted to synthesize findings from 11 selected studies. Results: In total 130 articles were explored and only 03 were found very relevant and 28 somewhat relevant based on inclusion criteria. Findings revealed that EI play a key role in any field specifically in effective leadership and leadership skills including empathy, self-management, and self-awareness. However, limitations including selection bias were acknowledged. Conclusion: The study concludes that EI can enhance the leadership role and can bring very significant advancement in the field of leadership. Since, there was no studies found that studied exclusively EI in relation with effective leadership

Advancing laboratory medicine in hospitals through health information exchange : a survey of specialist physicians in Canada

Background: Laboratory testing occupies a prominent place in health care. Information technology systems havethe potential to empower laboratory experts and to enhance the interpretation of test results in order to bettersupport physicians in their quest for better and safer patient care. This study sought to develop a better understanding ofwhich laboratory information exchange (LIE) systems and features specialist physicians are using in hospital settings toconsult their patients’laboratory test results, and what benefit they derive from such use. Methods: As part of a broader research program on the use of health information exchange systems for laboratorymedicine in Quebec, Canada, this study was designed as on online survey. Our sample is composed of 566 specialist physicians working in hospital settings, out of the 1512 physicians who responded to the survey (response rate of 17%).Respondents are representative of the targeted population of specialist physicians in terms of gender, age and hospital location.Results: We first observed that 80% of the surveyed physicians used the province-wide interoperable electronic health records (iEHR) system and 93% used a laboratory results viewer (LRV) to consult laboratory test results and most (72%) useboth systems to retrieve lab results. Next, our findings reveal important differences in the capabilities available in eachtype of system and in the use of these capabilities. Third, there are differences in the nature of the perceived benefits obtained from the use of each of these two systems. Last, the extent of use of an LRV is strongly influenced by the ITartefact itself (i.e., the hospital’s LRV available capabilities) while the use of the provincial iEHR system is influenced by its organizational context (i.e. the hospital’s size and location). Conclusions: The main contribution of this study lies in its insights into the role played by context in shaping physicians’ choices about which laboratory information exchange systems to adopt and which features to use, and the different perceptions they have about benefits arising from such use.One related implication for practice is that success of LIE initiatives should not be solely assessed with basic usage statistics

Can patients contribute to enhancing the safety and effectiveness of test‐result follow‐up? Qualitative outcomes from a health consumer workshop

Background Missed test‐results and failure to follow‐up test‐results are major patient safety concerns. Strategies to improve test‐results management have predominantly focused on clinician‐based interventions, with patients principally involved in studies of test‐result communication preferences, the impact of patient portals or experiences with reporting processes in primary care. Objective To identify consumer perspectives and experiences of the challenges they have faced with test‐results management, through consumer participation in qualitative data analysis. Design and participants Volunteers (n = 10) were recruited to participate in a health consumer reference group workshop on test‐results management. Prior to the workshop, consumers selected topics for discussion using a preference poll. During the workshop, consumers participated in qualitative data analysis of de‐identified excerpts of previously collected interview data discussing hospital test‐results management. Researchers (n = 5) guided consumers through the analytical process and discussion of themes. Discussions were audio‐recorded and transcribed for qualitative analysis. Results Consumer‐selected topics for discussion were 'Transitions of Care' and 'Access'. Consumer data analysis prompted broader discussion including lived experiences. Following the workshop, a second level of content analysis pinpointed issues with implications for patient safety highlighting that consumers were astutely aware of macrolevel 'Systems Factors' relating to 'Emergency Departments' and the health system, as well as microlevel 'Patient Factors' (eg patient preferences and circumstances) which impact a patient's understanding during the 'Communication' (clinician to patient/between clinicians) of test‐results 'Information' (or lack thereof). Conclusions Consumers identified the challenges patients experience with test‐results management, and our findings highlight areas for potential improvement in patient safety. Patient or public contribution Ten health consumer volunteers actively participated in the test‐results management data analysis workshop conducted in this study. Two health consumers also volunteered to read and comment on the draft manuscript.This work was supported by a National Health and Medical Research Council, Partnership Project Grant number APP1111925, involving The Australian Institute of Health Innovation at Macquarie University, NSW Health Pathology and The Australian Commission on Safety and Quality in Health Car

Evaluation, Validation & Implementation of a Computerized Diagnostic Decision Support System in Primary Practice

Background: Medical diagnosis may be the most complex task attempted by humans. Studies estimate that 95% of diagnoses in outpatient care are accurate, implying that the annual rate of inaccurate diagnoses is 12 million in the US alone, with the potential for patient harm in about half. A well-researched differential might reduce inaccurate diagnoses by offering alternatives matching the patient’s symptoms. This study searched the literature for articles evaluating the diagnostic performance of commercially available computerized diagnostic decision support systems. This search led to selecting Isabel Pro, developed by Isabel Healthcare, Ltd. of Haslemere, UK. Evaluation and Validation: A computerized diagnostic decision support system should respond adequately to four questions: What is the “diagnostic retrieval accuracy”? Does it perform as well as clinicians? When provided with the differential, do clinicians improve diagnostic accuracy? Is it easily incorporated into routine practice? The project validated the diagnostic retrieval accuracy of Isabel Pro using 46 cases with a previously confirmed diagnosis. The confirmed diagnosis appeared in Isabel Pro’s differential in 24 cases (52.2%), outperforming even internal medicine faculty (47%). Using those 24 cases and the differentials produced, the author conducted a diagnostic challenge that involved 120 McGovern Medical School residents. The residents produced 406 diagnoses, of which 105 (25.9%) were correct without the differentials, and 37 were correct post-consultation, a 9.1% absolute improvement. In responses, 75.1% of the participants agreed the differentials would be helpful in routine practice, and 64.1% agreed they would consult the differentials if available. Implementation: The project successfully proposed Isabel Pro as a solution to UT practice leadership on September 16, 2021, and incorporated the system into the Epic EHR as a menu line link on November 30, 2021. This system-wide integration also included a QR code for downloading Isabel Pro to a mobile device. Usage of Isabel Pro in the practices of UTPhysicians began on December 8, 2021. Results: The project concluded data collection after 86 days on March 4, 2022, with usage showing a steady increase in the final three weeks. The project produced 73 unique users (37 faculty and 36 residents). The user survey responses showed 83.3% agreeing they would consult the differential generated by Isabel Pro if available at every patient encounter (+19.2% compared to the challenge survey) and 77.8% agreeing that the suggestions would be helpful in routine practice (+2.7% compared to the challenge survey). More than one-third (36.8%) responded that they changed their diagnosis in response to the differential. Limitations: Only usage statistics were analyzed; the system records no reason for the clinician discontinuing a diagnostic session. Only 20 participants responded out of 73 (27.4%), so even though the respondents represented a spread of experience levels, the results may not represent the total number of potential users. The project covered a limited period of 86 days. Conclusions: Diagnostic inaccuracy is a significant patient safety concern. Studies show that computerized diagnostic decision support systems improve diagnostic accuracy, but they are not wide implementation lags despite these findings. This project demonstrated the feasibility of implementing such a well-known system in academic medical practice. The responses to the surveys demonstrate favorable opinions about the system’s perceived usefulness. Active communication and dissemination programs may be essential to improve and sustain use