Position-aware deep multi-task learning for drug–drug interaction extraction

Objective A drug–drug interaction (DDI) is a situation in which a drug affects the activity of another drug synergistically or antagonistically when being administered together. The information of DDIs is crucial for healthcare professionals to prevent adverse drug events. Although some known DDIs can be found in purposely-built databases such as DrugBank, most information is still buried in scientific publications. Therefore, automatically extracting DDIs from biomedical texts is sorely needed. Methods and material In this paper, we propose a novel position-aware deep multi-task learning approach for extracting DDIs from biomedical texts. In particular, sentences are represented as a sequence of word embeddings and position embeddings. An attention-based bidirectional long short-term memory (BiLSTM) network is used to encode each sentence. The relative position information of words with the target drugs in text is combined with the hidden states of BiLSTM to generate the position-aware attention weights. Moreover, the tasks of predicting whether or not two drugs interact with each other and further distinguishing the types of interactions are learned jointly in multi-task learning framework. Results The proposed approach has been evaluated on the DDIExtraction challenge 2013 corpus and the results show that with the position-aware attention only, our proposed approach outperforms the state-of-the-art method by 0.99% for binary DDI classification, and with both position-aware attention and multi-task learning, our approach achieves a micro F-score of 72.99% on interaction type identification, outperforming the state-of-the-art approach by 1.51%, which demonstrates the effectiveness of the proposed approach

A two-stage deep learning approach for extracting entities and relationships from medical texts

This Work Presents A Two-Stage Deep Learning System For Named Entity Recognition (Ner) And Relation Extraction (Re) From Medical Texts. These Tasks Are A Crucial Step To Many Natural Language Understanding Applications In The Biomedical Domain. Automatic Medical Coding Of Electronic Medical Records, Automated Summarizing Of Patient Records, Automatic Cohort Identification For Clinical Studies, Text Simplification Of Health Documents For Patients, Early Detection Of Adverse Drug Reactions Or Automatic Identification Of Risk Factors Are Only A Few Examples Of The Many Possible Opportunities That The Text Analysis Can Offer In The Clinical Domain. In This Work, Our Efforts Are Primarily Directed Towards The Improvement Of The Pharmacovigilance Process By The Automatic Detection Of Drug-Drug Interactions (Ddi) From Texts. Moreover, We Deal With The Semantic Analysis Of Texts Containing Health Information For Patients. Our Two-Stage Approach Is Based On Deep Learning Architectures. Concretely, Ner Is Performed Combining A Bidirectional Long Short-Term Memory (Bi-Lstm) And A Conditional Random Field (Crf), While Re Applies A Convolutional Neural Network (Cnn). Since Our Approach Uses Very Few Language Resources, Only The Pre-Trained Word Embeddings, And Does Not Exploit Any Domain Resources (Such As Dictionaries Or Ontologies), This Can Be Easily Expandable To Support Other Languages And Clinical Applications That Require The Exploitation Of Semantic Information (Concepts And Relationships) From Texts...This work was supported by the Research Program of the Ministry of Economy and Competitiveness - Government of Spain, (DeepEMR project TIN2017-87548-C2-1-R)

DDI Extraction Based on Transfer Weight Matrix and Memory Network

Extracting drug-drug interaction (DDI) in the text is the process of identifying how two target drugs in a given sentence interact. Previous methods, which were limited to conventional machine learning techniques, we are susceptible to issues such as “vocabulary gap” and unattainable automation processes in feature extraction. Inspired by deep learning in natural language preprocessing, we addressed the aforementioned problems based on dynamic transfer matrix and memory networks. A TM-RNN method is proposed by adding the transfer weight matrix in multilayer bidirectional LSTM to improve robustness and introduce a memory network for feature fusion. We evaluated the TM-RNN model on the DDIExtraction 2013 Task. The proposed model achieved an overall F-score of 72.43, which outperforms the latest methods based on support vector machine and other neural networks. Meanwhile, the experimental results also indicated that the proposed model is more stable and less affected by negative samples