IEEE Access Special Section Editorial: Big Data Technology and Applications in Intelligent Transportation

During the last few years, information technology and transportation industries, along with automotive manufacturers and academia, are focusing on leveraging intelligent transportation systems (ITS) to improve services related to driver experience, connected cars, Internet data plans for vehicles, traffic infrastructure, urban transportation systems, traffic collaborative management, road traffic accidents analysis, road traffic flow prediction, public transportation service plan, personal travel route plans, and the development of an effective ecosystem for vehicles, drivers, traffic controllers, city planners, and transportation applications. Moreover, the emerging technologies of the Internet of Things (IoT) and cloud computing have provided unprecedented opportunities for the development and realization of innovative intelligent transportation systems where sensors and mobile devices can gather information and cloud computing, allowing knowledge discovery, information sharing, and supported decision making. However, the development of such data-driven ITS requires the integration, processing, and analysis of plentiful information obtained from millions of vehicles, traffic infrastructures, smartphones, and other collaborative systems like weather stations and road safety and early warning systems. The huge amount of data generated by ITS devices is only of value if utilized in data analytics for decision-making such as accident prevention and detection, controlling road risks, reducing traffic carbon emissions, and other applications which bring big data analytics into the picture

Patient Safety and Quality: An Evidence-Based Handbook for Nurses

Compiles peer-reviewed research and literature reviews on issues regarding patient safety and quality of care, ranging from evidence-based practice, patient-centered care, and nurses' working conditions to critical opportunities and tools for improvement

Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors

A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided

CIRCUS 2001 Conference Proceedings: New Synergies in Digital Creativity. Conference for Content Integrated Research in Creative User Systems

CIRCUS (Content Integrated Research For Creative User Systems) was an ESPRIT Working Group, originally set up in 1988 as one of the very last additional actions in Framework 4, under DG III. Its purpose was to develop models for collaborative work between artists (the term here used in its widest sense) and technologists (ditto) and to promote these models by whatever means available. While some have criticised this aim as implicitly promoting a 1950s agenda of building bridges across C.P. Snow’s ‘two cultures’, there is no such intention here, rather that technology, particularly computer and communications technology (ICT) , is irresistibly intruding into what is normally thought of as creative work (and so practised by artists) and that, like any new technique, this has to be understood by its potential practitioners in terms of its true strengths and limitations. The specific problem that computer technology poses is that it is in principle malleable to such an extent that the limitations on its form and functionality are still barely understood, yet the people charged with the task of making the technology available have little or no understanding of the needs of creative users. What the artist usually sees is a tool which is in principle capable of being harnessed to creative ends but in practice resists being so applied. Quite often the tool is shaped more by blind economic forces than by a clear response to a specific, here creative, need. CIRCUS came into existence as a forum in which both artists and technologists could work out how best to play to the strengths of ICT and how to apply both creative and technological solutions (possibly both together) to its limitations. In particular the then new Framework V programme invited projects in such areas as new media but required them to be addressed in essentially the same old way, by technologists working towards commercialisation. The only obvious exception to this was in the area of cultural heritage which, incidentally, CIRCUS was also capable of reviewing. The scope for effective participation by artists was thus limited by an essentially technological agenda although everybody at the time, the participants of CIRCUS and programme managers in DG III, believed that we could do far better than this, and to develop new models of working which could inform the nature of Framework VI or even the later stages of F V. It is fair to say that everyone involved was excited by the idea of doing something quite new (and iconoclastic), not least the expanding of the expertise base on which future Frameworks could draw. It is also fair to say that, while not ultimately wholly original, the CIRCUS agenda was an ambitious one and the WG has had a chequered history peppered with misunderstandings perpetrated by the very people who might have thought would give the WG their strongest support. The CIRCUS idea has been aired before, specifically at the University of Illinois at Urbana- Champaign, the MIT Media Lab (and its imitators), and a recent IEEE forum. However a near total change in participation, fuelled by natural migration and a switch to DG XIII, has resulted in the CIRCUS agenda being restarted on at least one occasion and a fairly regular questioning of the principles on whose elucidation we are engaged. While this is no bad thing in principle, in practice we haven’t learned anything new from these periodic bouts of self-examination other than a reinforcement of the values our goals. On the other hand it is evident that we have made progress and have moved on a long way from where we started. A recent experience of a workshop whose agenda appeared to be to form another version of CIRCUS, this time with an overwhelmingly technological (DG III) membership, demonstrates they have a CIRCUS-worth of work to do before they will have reached where we are now. (Foreword of CIRCUS for Beginners

A record of research directed towards enhancement of the safety of clinical anaesthesia

Clinical Anaesthesia is an indispensable adjunct to the surgical treatment of disease. It directly affects the lives of a great number of people since every year no fewer than one in every twenty-five persons in the population is required to undergo a procedure which necessitates it. Of itself non-therapeutic, clinical anaesthesia must, above all else. be safe for the patient. Any adverse outcome to clinical anaesthesia and factors relevant to its administration results, at best, in postoperative morbidity for the patient and, at worst, his demise. Identification and examination of the factors and circumstances which have a material influence on the safety of anaesthesia for the patient, provided the motivation for and is the central theme of this collection of research publications which was submitted to the University of Cape Town in fulfilment of the requirements for the award of the Degree of Doctor of Science (Medicine). The publications submitted report the results of forty years of endeavour. In terms of their subject matter, these publications may be broadly grouped into the following five fields of interest: - 1) The Epidemiology of Death Attributable to Anaesthesia. 2) Pharmacogenetic States of concern to the Anaesthetist - a) The Malignant Hyperthermia Myopathy. b) The Acute Porphyrias. 3) The Effects of Anaesthetics on the Liver - Studies of Hepatic Drug Metabolism of relevance to post-Halothane Hepatitis and the hepatotoxicity of anaesthetic agents. b) The treatment of Fulminant Liver Failure. 4) Heat Homeostasis during Anaesthesia - a) Inadvertent Hypothermia during anaesthesia. b) Induced Hypothermia during anaesthesia. 5) Miscellaneous. Within these fields of interest, papers have been grouped in terms of related aspects of the main topic they cover. Editorial comment is included where appropriate. The nature and scope of many of the above investigations was such as to require, for their satisfactory conclusion, collaborative interdisciplinary research combining the endeavours of other clinicians and paramedical scientists. Appropriate recognition of such collaboration has resulted in the multiple authorship registered for many of the publications in this collection

Cultured allogeneic keratinocyte transplantation in the large white pig

Introduction: Banked cultured Langerhans cell (LC) free allogeneic keratinocytes, could be a readily available resource for the treatment of burns. The key questions that have not been resolved regarding the natural history of allotransplanted cultured keratinocytes, are when, how and why they are eliminated. Previous work at the Blond McIndoe Centre in a Large White pig model has demonstrated the survival of allotransplanted keratinocytes at three weeks in a ''chimeric" context (transplanting mixtures of autologous and allogeneic keratinocytes). The cultured cells were labelled by retroviral gene transfer to introduce a lacZnIs histochemically detectable marker. This work however, involved grafting onto de-epidermalised dermis that was shown to be capable of regenerating an epidermis without the aid of transplanted keratinocytes. Additionally, the keratinocyte labelling efficiency was low. The purpose of this study was to investigate the fate of cultured allogeneic transplanted keratinocytes, when they are the only source of epidermal tissue in a wound incapable of epidermal regeneration. To accomplish this, the aim was to develop a more efficient means of porcine keratinocyte labelling with the lacZnIs marker and to immunohistochemically characterise the cellular infiltrate with regard to allogeneic split skin graft rejection and compare this with the immune cell infiltrate associated with lacZnIs labelled LC-free cultured allogeneic keratinocytes grafted onto Integra(TM) (a non-regenerative dermal template). Methods: The Large White pig was used in view of the similarity of its skin architecture to humans. Retroviral gene transduction of cultured porcine keratinocytes was conducted with a MFGIacZnIs construct in the PT67amphotropic packaging cell line. Leucocyte phenotypes infiltrating porcine skin were characterised immunohistochemically using a panel of monoclonal antibodies specific to porcine antigens: CD1, CD3, CD4, CD5, CDS, CDS, CD25, CD45, SUKC3, SH/C6, SLA DP, SLA DP, SLA DR and igXLC with ABC staining. Porcine Jejunum was employed as a positive control. LC depletion with Anti-MHC II and complement vyas monitored using flow cytometry. MFGIacZnIs labelled LC-depleted cultured keratinocytes sheets and keratinocyte-dermal composites were auto and allografted onto Integra and onto deep fascia respectively. LacZnIs j3-galactosidase expression was detected using X-Gal staining of tissue biopsies at different time points up to 21 days following grafting and a reduced panel of monoclonal antibodies (omitting CDS, SLA DP and SLA DQ) was used to immunophenotype the infiltrate at these time points. Results: The new PTS7 producer line succeeded in achieving close to 100% of keratinocyte transduction with the MFG lacZ construct following three passages in a cell culture system containing irradiated retroviral producer cells and 3T3 fibroblasts as feeder cells. Stability was demonstrated with no apparent reduction in lacZnis expression by porcine keratinocytes following a further seven passages on irradiated STS fibroblasts. A reduction was demonstrated however, both in the number and size of colonies formed by keratinocytes following transduction. LCs were shown to be successfully eliminated from disaggregated epidermal cells using antibody and complement. We also demonstrated that overnight incubation results in up regulation of MHC class II antigen and increases the efficiency of LC elimination. As with retrovirally transduced keratinocytes a reduction was demonstrated however, both in the number and size of colonies formed by keratinocytes that had undergone treatment with antibody and complement. The differential distribution of leucocyte phenotypes as determined by the panel of antibodies within normal porcine skin was shown for the first time

Patent Law: Cases & Materials ~ Version 2.0

The book contains edited cases, patent figures, and excerpts, along with brief introductions on patent law. This book is designed for use in close conjunction with a specific softcover hornbook published by Wolters Kluwer, Janice Mueller’s, Patent Law, Fourth Edition (Aspen Student Treatise Series 2013). If you decide to use this case collection to teach a course of your own — as I hope people will — please check back to ensure that you have the most up-to-date version. This version, which is 2.0, was posted in June 2015. Reproduced and linked with permission of the author.https://digitalcommons.law.uga.edu/books/1101/thumbnail.jp

Smoking and Second Hand Smoking in Adolescents with Chronic Kidney Disease: A Report from the Chronic Kidney Disease in Children (CKiD) Cohort Study

The goal of this study was to determine the prevalence of smoking and second hand smoking [SHS] in adolescents with CKD and their relationship to baseline parameters at enrollment in the CKiD, observational cohort study of 600 children (aged 1-16 yrs) with Schwartz estimated GFR of 30-90 ml/min/1.73m2. 239 adolescents had self-report survey data on smoking and SHS exposure: 21 [9%] subjects had “ever” smoked a cigarette. Among them, 4 were current and 17 were former smokers. Hypertension was more prevalent in those that had “ever” smoked a cigarette (42%) compared to non-smokers (9%), p\u3c0.01. Among 218 non-smokers, 130 (59%) were male, 142 (65%) were Caucasian; 60 (28%) reported SHS exposure compared to 158 (72%) with no exposure. Non-smoker adolescents with SHS exposure were compared to those without SHS exposure. There was no racial, age, or gender differences between both groups. Baseline creatinine, diastolic hypertension, C reactive protein, lipid profile, GFR and hemoglobin were not statistically different. Significantly higher protein to creatinine ratio (0.90 vs. 0.53, p\u3c0.01) was observed in those exposed to SHS compared to those not exposed. Exposed adolescents were heavier than non-exposed adolescents (85th percentile vs. 55th percentile for BMI, p\u3c 0.01). Uncontrolled casual systolic hypertension was twice as prevalent among those exposed to SHS (16%) compared to those not exposed to SHS (7%), though the difference was not statistically significant (p= 0.07). Adjusted multivariate regression analysis [OR (95% CI)] showed that increased protein to creatinine ratio [1.34 (1.03, 1.75)] and higher BMI [1.14 (1.02, 1.29)] were independently associated with exposure to SHS among non-smoker adolescents. These results reveal that among adolescents with CKD, cigarette use is low and SHS is highly prevalent. The association of smoking with hypertension and SHS with increased proteinuria suggests a possible role of these factors in CKD progression and cardiovascular outcomes

The life and work of the Revd. T.H.E.C. Espin perpetual curate of tow law with special reference to his astronomical research

Not availabl