3,760 research outputs found
Aducanumab, Accelerated Approvals & the Agency: Why the FDA Needs Structural Reform
The US Food and Drug Administrationâs controversial decision to grant accelerated approval to aducanumab (Aduhelm), a therapy for Alzheimerâs disease, has motivated multiple policy reforms. Drawing upon a case series of other drugs granted accelerated approval and interviews of senior FDA officials, I argue that reform should be informed but not defined by aducanumab. Rather, structural reforms are needed to reshape FDAâs core priorities and restore the regulatory systemâs commitment to scientific rigor
LIPIcs, Volume 251, ITCS 2023, Complete Volume
LIPIcs, Volume 251, ITCS 2023, Complete Volum
A Critical Review Of Post-Secondary Education Writing During A 21st Century Education Revolution
Educational materials are effective instruments which provide information and report new discoveries uncovered by researchers in specific areas of academia. Higher education, like other education institutions, rely on instructional materials to inform its practice of educating adult learners. In post-secondary education, developmental English programs are tasked with meeting the needs of dynamic populations, thus there is a continuous need for research in this area to support its changing landscape. However, the majority of scholarly thought in this area centers on K-12 reading and writing. This paucity presents a phenomenon to the post-secondary community. This research study uses a qualitative content analysis to examine peer-reviewed journals from 2003-2017, developmental online websites, and a government issued document directed toward reforming post-secondary developmental education programs. These highly relevant sources aid educators in discovering informational support to apply best practices for student success. Developmental education serves the purpose of addressing literacy gaps for students transitioning to college-level work. The findings here illuminate the dearth of material offered to developmental educators. This study suggests the field of literacy research is fragmented and highlights an apparent blind spot in scholarly literature with regard to English writing instruction. This poses a quandary for post-secondary literacy researchers in the 21st century and establishes the necessity for the literacy research community to commit future scholarship toward equipping college educators teaching writing instruction to underprepared adult learners
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Understanding the Impact of Covid-19 on Ethnic Minority Students: a Case Study of Open University Level 1 Computing Modules
As reported in [1] âOf the disparities that exist within higher education, the gap between the likelihood of White students and students from Black, Asian or minority ethnic backgrounds getting a first- or upper-second-class degree is among the starkestâ. In the Open University (OU) for example, a recent research [2] found students from ethnic minorities to be at least 20% less likely to achieve excellent grades and to spend 4-12% more of study time to achieve the same performance as white students. Moreover, with the advent of COVID-19, a growing body of research suggested that students from these groups of the population, suffer disproportionally from the impacts of the pandemic [3], which inevitably impacts on their study experiences. However, recent research in the OU found that some COVID-19 arrangements such as the change of examination mode and change in work-life patterns have impacted students from ethnic minority backgrounds differently. In this paper we present findings from a project aiming to understand the impact of COVID-19 on ethnic minority studentsâ study experiences and performance. By means of a combination of qualitative and quantitative data analytics we first analysed the study performance and the patterns of progression, then by conducting focus groups with the teaching staff we assessed the impact of COVID-19 on the lived experiences of the students.
[1] Black, Asian and Minority Ethnic Student Attainment at UK Universities (2022). Available at: https://www.universitiesuk.ac.uk.
[2] Nguyen Q., Rienties B. Richardson J.T.E. (2020) Learning analytics to uncover inequality in behavioural engagement and academic attainment in a distance learning setting, Assessment & Evaluation in Higher Education, 45:4, 594-606.
[3] Arday, J. and Jones, C. (2022) âSame storm, different boats: The impact of covid-19 on black students and academic staff in UK and US higher education,â Higher Education. Available at:
https://doi.org/10.1007/s10734-022-00939-0
Talking about personal recovery in bipolar disorder: Integrating health research, natural language processing, and corpus linguistics to analyse peer online support forum posts
Background: Personal recovery, âliving a satisfying, hopeful and contributing lifeeven with the limitations caused by the illnessâ (Anthony, 1993) is of particular value in bipolar disorder where symptoms often persist despite treatment. So far, personal recovery has only been studied in researcher-constructed environments (interviews, focus groups). Support forum posts can serve as a complementary naturalistic data source. Objective: The overarching aim of this thesis was to study personal recovery experiences that people living with bipolar disorder have shared in online support forums through integrating health research, NLP, and corpus linguistics in a mixed methods approach within a pragmatic research paradigm, while considering ethical issues and involving people with lived experience. Methods: This mixed-methods study analysed: 1) previous qualitative evidence on personal recovery in bipolar disorder from interviews and focus groups 2) who self-reports a bipolar disorder diagnosis on the online discussion platform Reddit 3) the relationship of mood and posting in mental health-specific Reddit forums (subreddits) 4) discussions of personal recovery in bipolar disorder subreddits. Results: A systematic review of qualitative evidence resulted in the first framework for personal recovery in bipolar disorder, POETIC (Purpose & meaning, Optimism & hope, Empowerment, Tensions, Identity, Connectedness). Mainly young or middle-aged US-based adults self-report a bipolar disorder diagnosis on Reddit. Of these, those experiencing more intense emotions appear to be more likely to post in mental health support subreddits. Their personal recovery-related discussions in bipolar disorder subreddits primarily focussed on three domains: Purpose & meaning (particularly reproductive decisions, work), Connectedness (romantic relationships, social support), Empowerment (self-management, personal responsibility). Support forum data highlighted personal recovery issues that exclusively or more frequently came up online compared to previous evidence from interviews and focus groups. Conclusion: This project is the first to analyse non-reactive data on personal recovery in bipolar disorder. Indicating the key areas that people focus on in personal recovery when posting freely and the language they use provides a helpful starting point for formal and informal carers to understand the concerns of people diagnosed with bipolar disorder and to consider how best to offer support
Behavioral effects of public service motivation among citizens: testing the case of digital co-production
In times where governments are increasingly unable to solve problems on their own, it is important to understand what motivates citizens to engage in co-production. Drawing on identity theory and on a sample of 966 citizens in Zurich, Switzerland, we analyze how public service motivation (PSM) is related to engagement in a digital co-production platform enabling citizens to support public service provision. As our dependent variable, effort intensity in platform use, is a behavioral outcome, we provide insights into the actual behavioral implications of PSM, going beyond self-reports. Using negative binomial regressions, we found a positive relationship between engagement and the PSM dimension âcommitment to the public interestâ, and a negative one with the dimension âcompassionâ. Additionally, social identification with the city moderates the relationship with engagement for certain PSM dimensions. In sum, our study contributes to a better understanding of what motivations drive citizens to collaborate with public organizations, which is an ongoing trend in many countries around the world
The effect of lockup and persuasion on online investment decisions: an experimental study in ICOs
Many firms use social media (SM) to solicit online investments. In this study, we examine the interaction between SM attributes and online-investment attributes to determine how this interaction shapes usersâ investment decisions. Specifically, we investigate initial coin offerings (ICOs) as an application domain of distributed ledger technology for peer-to-peer investment. We use signaling theory to develop a context-specific explanation for how the interplay of persuasion signals found in SM and technology-enforced lockups shapes individualsâ ICO investment decisions. To evaluate this interplay, we conducted a 2âĂâ2 factorial experiment with 473 participants. The results show that when an investment does not require a technology-enforced lockup, persuasion signals encourage investments in ICOs; however, when an investment requires a technology-enforced lockup, persuasion signals do not affect investments in ICOs. Furthermore, our analyses suggest that combining a technology-enforced lockup and persuasion signals reduces the ICOâs plausibility. This is the first study to investigate how the willingness to invest in ICOs is influenced by the relationship between technology-enforced lockups and persuasion signals. The findings have practical implications for individuals attempting to make sound decisions on ICO investments, policymakers regulating online investments, and firms seeking to attract investors
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