Pattern vectors from algebraic graph theory

Graphstructures have proven computationally cumbersome for pattern analysis. The reason for this is that, before graphs can be converted to pattern vectors, correspondences must be established between the nodes of structures which are potentially of different size. To overcome this problem, in this paper, we turn to the spectral decomposition of the Laplacian matrix. We show how the elements of the spectral matrix for the Laplacian can be used to construct symmetric polynomials that are permutation invariants. The coefficients of these polynomials can be used as graph features which can be encoded in a vectorial manner. We extend this representation to graphs in which there are unary attributes on the nodes and binary attributes on the edges by using the spectral decomposition of a Hermitian property matrix that can be viewed as a complex analogue of the Laplacian. To embed the graphs in a pattern space, we explore whether the vectors of invariants can be embedded in a low- dimensional space using a number of alternative strategies, including principal components analysis ( PCA), multidimensional scaling ( MDS), and locality preserving projection ( LPP). Experimentally, we demonstrate that the embeddings result in well- defined graph clusters. Our experiments with the spectral representation involve both synthetic and real- world data. The experiments with synthetic data demonstrate that the distances between spectral feature vectors can be used to discriminate between graphs on the basis of their structure. The real- world experiments show that the method can be used to locate clusters of graphs

Latent tree models

Latent tree models are graphical models defined on trees, in which only a subset of variables is observed. They were first discussed by Judea Pearl as tree-decomposable distributions to generalise star-decomposable distributions such as the latent class model. Latent tree models, or their submodels, are widely used in: phylogenetic analysis, network tomography, computer vision, causal modeling, and data clustering. They also contain other well-known classes of models like hidden Markov models, Brownian motion tree model, the Ising model on a tree, and many popular models used in phylogenetics. This article offers a concise introduction to the theory of latent tree models. We emphasise the role of tree metrics in the structural description of this model class, in designing learning algorithms, and in understanding fundamental limits of what and when can be learned

Petri nets for systems and synthetic biology

We give a description of a Petri net-based framework for modelling and analysing biochemical pathways, which uni¯es the qualita- tive, stochastic and continuous paradigms. Each perspective adds its con- tribution to the understanding of the system, thus the three approaches do not compete, but complement each other. We illustrate our approach by applying it to an extended model of the three stage cascade, which forms the core of the ERK signal transduction pathway. Consequently our focus is on transient behaviour analysis. We demonstrate how quali- tative descriptions are abstractions over stochastic or continuous descrip- tions, and show that the stochastic and continuous models approximate each other. Although our framework is based on Petri nets, it can be applied more widely to other formalisms which are used to model and analyse biochemical networks

Metric Dimension of Amalgamation of Graphs

A set of vertices $S$ resolves a graph $G$ if every vertex is uniquely determined by its vector of distances to the vertices in $S$. The metric dimension of $G$ is the minimum cardinality of a resolving set of $G$. Let $\{G_1, G_2, \ldots, G_n\}$ be a finite collection of graphs and each $G_i$ has a fixed vertex $v_{0_i}$ or a fixed edge $e_{0_i}$ called a terminal vertex or edge, respectively. The \emph{vertex-amalgamation} of $G_1, G_2, \ldots, G_n$, denoted by $Vertex-Amal\{G_i;v_{0_i}\}$, is formed by taking all the $G_i$'s and identifying their terminal vertices. Similarly, the \emph{edge-amalgamation} of $G_1, G_2, \ldots, G_n$, denoted by $Edge-Amal\{G_i;e_{0_i}\}$, is formed by taking all the $G_i$'s and identifying their terminal edges. Here we study the metric dimensions of vertex-amalgamation and edge-amalgamation for finite collection of arbitrary graphs. We give lower and upper bounds for the dimensions, show that the bounds are tight, and construct infinitely many graphs for each possible value between the bounds.Comment: 9 pages, 2 figures, Seventh Czech-Slovak International Symposium on Graph Theory, Combinatorics, Algorithms and Applications (CSGT2013), revised version 21 December 201

Distances and Isomorphism between Networks and the Stability of Network Invariants

We develop the theoretical foundations of a network distance that has recently been applied to various subfields of topological data analysis, namely persistent homology and hierarchical clustering. While this network distance has previously appeared in the context of finite networks, we extend the setting to that of compact networks. The main challenge in this new setting is the lack of an easy notion of sampling from compact networks; we solve this problem in the process of obtaining our results. The generality of our setting means that we automatically establish results for exotic objects such as directed metric spaces and Finsler manifolds. We identify readily computable network invariants and establish their quantitative stability under this network distance. We also discuss the computational complexity involved in precisely computing this distance, and develop easily-computable lower bounds by using the identified invariants. By constructing a wide range of explicit examples, we show that these lower bounds are effective in distinguishing between networks. Finally, we provide a simple algorithm that computes a lower bound on the distance between two networks in polynomial time and illustrate our metric and invariant constructions on a database of random networks and a database of simulated hippocampal networks