Petuum: A New Platform for Distributed Machine Learning on Big Data

What is a systematic way to efficiently apply a wide spectrum of advanced ML programs to industrial scale problems, using Big Models (up to 100s of billions of parameters) on Big Data (up to terabytes or petabytes)? Modern parallelization strategies employ fine-grained operations and scheduling beyond the classic bulk-synchronous processing paradigm popularized by MapReduce, or even specialized graph-based execution that relies on graph representations of ML programs. The variety of approaches tends to pull systems and algorithms design in different directions, and it remains difficult to find a universal platform applicable to a wide range of ML programs at scale. We propose a general-purpose framework that systematically addresses data- and model-parallel challenges in large-scale ML, by observing that many ML programs are fundamentally optimization-centric and admit error-tolerant, iterative-convergent algorithmic solutions. This presents unique opportunities for an integrative system design, such as bounded-error network synchronization and dynamic scheduling based on ML program structure. We demonstrate the efficacy of these system designs versus well-known implementations of modern ML algorithms, allowing ML programs to run in much less time and at considerably larger model sizes, even on modestly-sized compute clusters.Comment: 15 pages, 10 figures, final version in KDD 2015 under the same titl

Clustering-Based Predictive Process Monitoring

Business process enactment is generally supported by information systems that record data about process executions, which can be extracted as event logs. Predictive process monitoring is concerned with exploiting such event logs to predict how running (uncompleted) cases will unfold up to their completion. In this paper, we propose a predictive process monitoring framework for estimating the probability that a given predicate will be fulfilled upon completion of a running case. The predicate can be, for example, a temporal logic constraint or a time constraint, or any predicate that can be evaluated over a completed trace. The framework takes into account both the sequence of events observed in the current trace, as well as data attributes associated to these events. The prediction problem is approached in two phases. First, prefixes of previous traces are clustered according to control flow information. Secondly, a classifier is built for each cluster using event data to discriminate between fulfillments and violations. At runtime, a prediction is made on a running case by mapping it to a cluster and applying the corresponding classifier. The framework has been implemented in the ProM toolset and validated on a log pertaining to the treatment of cancer patients in a large hospital

Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues