Loss of brain inter-frequency hubs in Alzheimer's disease

Alzheimer's disease (AD) causes alterations of brain network structure and function. The latter consists of connectivity changes between oscillatory processes at different frequency channels. We proposed a multi-layer network approach to analyze multiple-frequency brain networks inferred from magnetoencephalographic recordings during resting-states in AD subjects and age-matched controls. Main results showed that brain networks tend to facilitate information propagation across different frequencies, as measured by the multi-participation coefficient (MPC). However, regional connectivity in AD subjects was abnormally distributed across frequency bands as compared to controls, causing significant decreases of MPC. This effect was mainly localized in association areas and in the cingulate cortex, which acted, in the healthy group, as a true inter-frequency hub. MPC values significantly correlated with memory impairment of AD subjects, as measured by the total recall score. Most predictive regions belonged to components of the default-mode network that are typically affected by atrophy, metabolism disruption and amyloid-beta deposition. We evaluated the diagnostic power of the MPC and we showed that it led to increased classification accuracy (78.39%) and sensitivity (91.11%). These findings shed new light on the brain functional alterations underlying AD and provide analytical tools for identifying multi-frequency neural mechanisms of brain diseases.Comment: 27 pages, 6 figures, 3 tables, 3 supplementary figure

CSP channels for CAN-bus connected embedded control systems

Closed loop control system typically contains multitude of sensors and actuators operated simultaneously. So they are parallel and distributed in its essence. But when mapping this parallelism to software, lot of obstacles concerning multithreading communication and synchronization issues arise. To overcome this problem, the CT kernel/library based on CSP algebra has been developed. This project (TES.5410) is about developing communication extension to the CT library to make it applicable in distributed systems. Since the library is tailored for control systems, properties and requirements of control systems are taken into special consideration. Applicability of existing middleware solutions is examined. A comparison of applicable fieldbus protocols is done in order to determine most suitable ones and CAN fieldbus is chosen to be first fieldbus used. Brief overview of CSP and existing CSP based libraries is given. Middleware architecture is proposed along with few novel ideas

Simple Random Sampling-Based Probe Station Selection for Fault Detection in Wireless Sensor Networks

Fault detection for wireless sensor networks (WSNs) has been studied intensively in recent years. Most existing works statically choose the manager nodes as probe stations and probe the network at a fixed frequency. This straightforward solution leads however to several deficiencies. Firstly, by only assigning the fault detection task to the manager node the whole network is out of balance, and this quickly overloads the already heavily burdened manager node, which in turn ultimately shortens the lifetime of the whole network. Secondly, probing with a fixed frequency often generates too much useless network traffic, which results in a waste of the limited network energy. Thirdly, the traditional algorithm for choosing a probing node is too complicated to be used in energy-critical wireless sensor networks. In this paper, we study the distribution characters of the fault nodes in wireless sensor networks, validate the Pareto principle that a small number of clusters contain most of the faults. We then present a Simple Random Sampling-based algorithm to dynamic choose sensor nodes as probe stations. A dynamic adjusting rule for probing frequency is also proposed to reduce the number of useless probing packets. The simulation experiments demonstrate that the algorithm and adjusting rule we present can effectively prolong the lifetime of a wireless sensor network without decreasing the fault detected rate

MEG sensor and source measures of visually induced gamma-band oscillations are highly reliable

High frequency brain oscillations are associated with numerous cognitive and behavioral processes. Non-invasive measurements using electro-/magnetoencephalography (EEG/MEG) have revealed that high frequency neural signals are heritable and manifest changes with age as well as in neuropsychiatric illnesses. Despite the extensive use of EEG/MEG-measured neural oscillations in basic and clinical research, studies demonstrating test–retest reliability of power and frequency measures of neural signals remain scarce. Here, we evaluated the test–retest reliability of visually induced gamma (30–100 Hz) oscillations derived from sensor and source signals acquired over two MEG sessions. The study required participants (N = 13) to detect the randomly occurring stimulus acceleration while viewing a moving concentric grating. Sensor and source MEG measures of gamma-band activity yielded comparably strong reliability (average intraclass correlation, ICC = 0.861). Peak stimulus-induced gamma frequency (53–72 Hz) yielded the highest measures of stability (ICCsensor = 0.940; ICCsource = 0.966) followed by spectral signal change (ICCsensor = 0.890; ICCsource = 0.893) and peak frequency bandwidth (ICCsensor = 0.856; ICCsource = 0.622). Furthermore, source-reconstruction significantly improved signal-to-noise for spectral amplitude of gamma activity compared to sensor estimates. Our assessments highlight that both sensor and source derived estimates of visually induced gamma-band oscillations from MEG signals are characterized by high test–retest reliability, with source derived oscillatory measures conferring an improvement in the stability of peak-frequency estimates. Importantly, our finding of high test–retest reliability supports the feasibility of pharma-MEG studies and longitudinal aging or clinical studies

Reliability of Graph Measures Derived from Resting-State MEG Data Using Source Space Functional Connectivity Analysis

The reliability of global graph measures derived from neuroimaging data is an important criterion for their use as biomarkers for neurological disorders. This study examined the reliability of the global efficiency (GE), characteristic path length (CPL), transitivity, and synchronizability of functional whole-brain and intra-hemispheric networks based on resting-state magnetoencephalography. Brain sources were reconstructed using atlas-based beamforming, and functional connectivity in six frequency bands was estimated using the debiased weighted phase lag index. An optimal threshold of 100% was chosen based on test-retest reliability of the measures. At this threshold, test-retest reliability of the GE, CPL, and transitivity was mostly fair to excellent except for in the delta band. However, test-retest reliability of the synchronizability was mostly poor to fair. There was no significant effect of gender on any graph measure. Overall, these results indicate that the GE, CPL, and transitivity in most of the frequency bands may be useful biomarkers

Wide-Area Synchrophasor Measurement Applications and Power System Dynamic Modeling

The use of synchrophasor measurements system-wide has been providing significant assistance for grid dynamic monitoring, situation awareness and reliability improvement. Frequency Monitoring Network (FNET), as an academia-run synchrophasor measurement system, utilizes a large number of Internet-connected low-cost Frequency Disturbance Recorders (FDRs) installed at the distribution level to measure power system dynamics and provide both online and off-line applications, such as event detection, oscillation modes estimation, event replay, etc. This work aims to further explore applications of the FNET measurements and utilize measurement-based method in dynamic modeling. Measurement-based dynamic reduction is an important application of synchrophasor measurement, especially considering the fact that when the system model is large, measurements provide a precise insight of system dynamics in order to determine equivalent regions. Another important application is to investigate Super Bowl games as an example to evaluate the influence of synchronized human activities on the power system. Featured characteristics drawn from the frequency data detected during the Super Bowl games are discussed. Increased penetration levels of wind generation and retirements of conventional plants have caused concerns about a decline of system inertia and primary frequency response. This work evaluates the impact of wind power on the system inertial response, simulation scenarios with different wind penetration levels are developed based on the U.S. Northeast Power Coordinating Council (NPCC) system. A user-defined electrical control model is also introduced to provide inertia and governor control to wind generations. Except for wind generation, frequency regulation can also be achieved by supplementary control of High Voltage Direct Current (HVDC) transmission line. A multi-terminal Voltage Source Converter (VSC) HVDC model is constructed to prove the effective control. In order to transmit large amount of intermittent and remote renewable energy over long distance to load centers, a potential solution is to upgrade the transmission system at a higher voltage by constructing an overlay HVDC grid on top of the original transmission system. The VSC HVDC model is utilized to build the HVDC overlay grid, and the overlay grid is tested with interconnection models. Conclusions and possible future research topics are given in the end

Ubiquitous Computing

The aim of this book is to give a treatment of the actively developed domain of Ubiquitous computing. Originally proposed by Mark D. Weiser, the concept of Ubiquitous computing enables a real-time global sensing, context-aware informational retrieval, multi-modal interaction with the user and enhanced visualization capabilities. In effect, Ubiquitous computing environments give extremely new and futuristic abilities to look at and interact with our habitat at any time and from anywhere. In that domain, researchers are confronted with many foundational, technological and engineering issues which were not known before. Detailed cross-disciplinary coverage of these issues is really needed today for further progress and widening of application range. This book collects twelve original works of researchers from eleven countries, which are clustered into four sections: Foundations, Security and Privacy, Integration and Middleware, Practical Applications

Dynamic Construction of Stimulus Values in the Ventromedial Prefrontal Cortex

Signals representing the value assigned to stimuli at the time of choice have been repeatedly observed in ventromedial prefrontal cortex (vmPFC). Yet it remains unknown how these value representations are computed from sensory and memory representations in more posterior brain regions. We used electroencephalography (EEG) while subjects evaluated appetitive and aversive food items to study how event-related responses modulated by stimulus value evolve over time. We found that value-related activity shifted from posterior to anterior, and from parietal to central to frontal sensors, across three major time windows after stimulus onset: 150–250 ms, 400–550 ms, and 700–800 ms. Exploratory localization of the EEG signal revealed a shifting network of activity moving from sensory and memory structures to areas associated with value coding, with stimulus value activity localized to vmPFC only from 400 ms onwards. Consistent with these results, functional connectivity analyses also showed a causal flow of information from temporal cortex to vmPFC. Thus, although value signals are present as early as 150 ms after stimulus onset, the value signals in vmPFC appear relatively late in the choice process, and seem to reflect the integration of incoming information from sensory and memory related regions

Reconfigurable AUV for Intervention Missions: A Case Study on Underwater Object Recovery

Starting in January 2009, the RAUVI (Reconfigurable Autonomous Underwater Vehicle for Intervention Missions) project is a 3-year coordinated research action funded by the Spanish Ministry of Research and Innovation. In this paper, the state of progress after 2 years of continuous research is reported. As a first experimental validation of the complete system, a search and recovery problem is addressed, consisting of finding and recovering a flight data recorder placed at an unknown position at the bottom of a water tank. An overview of the techniques used to successfully solve the problem in an autonomous way is provided. The obtained results are very promising and are the first step toward the final test in shallow water at the end of 2011

A Secure Healthcare 5.0 System Based on Blockchain Technology Entangled with Federated Learning Technique

In recent years, the global Internet of Medical Things (IoMT) industry has evolved at a tremendous speed. Security and privacy are key concerns on the IoMT, owing to the huge scale and deployment of IoMT networks. Machine learning (ML) and blockchain (BC) technologies have significantly enhanced the capabilities and facilities of healthcare 5.0, spawning a new area known as "Smart Healthcare." By identifying concerns early, a smart healthcare system can help avoid long-term damage. This will enhance the quality of life for patients while reducing their stress and healthcare costs. The IoMT enables a range of functionalities in the field of information technology, one of which is smart and interactive health care. However, combining medical data into a single storage location to train a powerful machine learning model raises concerns about privacy, ownership, and compliance with greater concentration. Federated learning (FL) overcomes the preceding difficulties by utilizing a centralized aggregate server to disseminate a global learning model. Simultaneously, the local participant keeps control of patient information, assuring data confidentiality and security. This article conducts a comprehensive analysis of the findings on blockchain technology entangled with federated learning in healthcare. 5.0. The purpose of this study is to construct a secure health monitoring system in healthcare 5.0 by utilizing a blockchain technology and Intrusion Detection System (IDS) to detect any malicious activity in a healthcare network and enables physicians to monitor patients through medical sensors and take necessary measures periodically by predicting diseases.Comment: 20 pages, 6 tables, 3 figure