Epidemiology of injuries in high-level youth sport in Luxembourg [Abstract]

peer reviewe

Osteoarthritis

Osteoarthritis is one of the most debilitating diseases affecting millions of people worldwide. However, there is no FDA approved disease modifying drug specifically for OA. Surgery remains an effective last resort to restore the function of the joints. As the aging populations increase worldwide, the number of OA patients increases dramatically in recent years and is expected to increase in many years to come. This is a book that summarizes recent advance in OA diagnosis, treatment, and surgery. It includes wide ranging topics from the cutting edge gene therapy to alternative medicine. Such multifaceted approaches are necessary to develop novel and effective therapy to cure OA in the future. In this book, different surgical methods are described to restore the function of the joints. In addition, various treatment options are presented, mainly to reduce the pain and enhance the life quality of the OA patients

Patient-Specific Implants in Musculoskeletal (Orthopedic) Surgery

Most of the treatments in medicine are patient specific, aren’t they? So why should we bother with individualizing implants if we adapt our therapy to patients anyway? Looking at the neighboring field of oncologic treatment, you would not question the fact that individualization of tumor therapy with personalized antibodies has led to the thriving of this field in terms of success in patient survival and positive responses to alternatives for conventional treatments. Regarding the latest cutting-edge developments in orthopedic surgery and biotechnology, including new imaging techniques and 3D-printing of bone substitutes as well as implants, we do have an armamentarium available to stimulate the race for innovation in medicine. This Special Issue of Journal of Personalized Medicine will gather all relevant new and developed techniques already in clinical practice. Examples include the developments in revision arthroplasty and tumor (pelvic replacement) surgery to recreate individual defects, individualized implants for primary arthroplasty to establish physiological joint kinematics, and personalized implants in fracture treatment, to name but a few

Musculoskeletal Diseases 2021-2024

This open access book focuses on imaging of the musculoskeletal diseases. Over the last few years, there have been considerable advances in this area, driven by clinical as well as technological developments. The authors are all internationally renowned experts in their field. They are also excellent teachers, and provide didactically outstanding chapters. The book is disease-oriented and covers all relevant imaging modalities, with particular emphasis on magnetic resonance imaging. Important aspects of pediatric imaging are also included. IDKD books are completely re-written every four years. As a result, they offer a comprehensive review of the state of the art in imaging. The book is clearly structured with learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers easily navigate through the text. As an IDKD book, it is particularly valuable for general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic knowledge, and for clinicians interested in imaging as it relates to their specialty

Musculoskeletal Diseases 2021-2024

This open access book focuses on imaging of the musculoskeletal diseases. Over the last few years, there have been considerable advances in this area, driven by clinical as well as technological developments. The authors are all internationally renowned experts in their field. They are also excellent teachers, and provide didactically outstanding chapters. The book is disease-oriented and covers all relevant imaging modalities, with particular emphasis on magnetic resonance imaging. Important aspects of pediatric imaging are also included. IDKD books are completely re-written every four years. As a result, they offer a comprehensive review of the state of the art in imaging. The book is clearly structured with learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers easily navigate through the text. As an IDKD book, it is particularly valuable for general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic knowledge, and for clinicians interested in imaging as it relates to their specialty

Imaging findings after meniscal repair with degradable polyurethane scaffold: preliminary results.

Purpose / Introduction: To date, there are no satisfactory solutions to the meniscal originated knee pain post meniscal tear repair. In this study a newly developed polyurethane material that has the intended properties of reducing pain and inducing tissue growth in a damaged meniscus is tested. Materials and Methods: All patients will be imaged using conventional and dynamic MR imaging techniques at 1 week and 3, 12 and 24 months after surgery. The influx of gadolinium contrast in a tissue during the first three minutes after injection gives a measure of the vascularisation, capillary permeability, perfusion and composition of the interstitial fluid. It can be measured using dynamic MRI and is represented as a Time Intensity Curve (TIC). This curve permits an evaluation of the healing process after surgery. Discussion / Conclusion: Thus far 11 patients have received meniscal implants. Eight medial and three lateral menisci were operated. All implants covered the posterior horn with 3 reaching halfway into the meniscal body and one extending into the anterior horn. The average length of the scaffold meniscus measured on MR imaging was 45mm. In the first week after surgery, the capsule and suture area display fast and intense enhancement typical for post-operative inflammation and the formation of early scar-tissue. There is no enhancement in the base or the tip of the scaffold meniscus. After three months the speed and intensity of enhancement in the capsule and suture area between the remnants of the native meniscus and the scaffold have decreased indicating maturation of scar-tissue. However, the base of the scaffold meniscus now shows enhancement. This can only be explained by proliferation of blood vessels from the capsule and theresidual meniscus wall into the scaffold meniscus. The tip of the matrix shows limited enhancement in some patients after three months. On anatomical MR images, the signal intensity (SI) of the implanted scaffold is close to that of water on both T1- and T2-weighted spin echo and turbo spin echo sequences in the first week. After three months the SI decreases but is still clearly higher than that of the native meniscus. The implants in the posterior horn all had a normal position and no loosening of the sutures or tears of the scaffold were found. After three months, one of the patients had slight expulsion of body of the scaffold meniscus but this is a common finding in transplanted menisci

Three-dimensional computation of femoral canine morphological parameters: from the theory to the surgery application

The present research was envisioned as a project defined by multiple studies that are strictly correlated each other. The report of the birth, development and practical application to the diagnostic and surgery fields of a novel 3D approach for the computation of femoral measurements was the first aim. Moreover, in the authors’ purpose the description of the translational value of the proposed procedure enhanced with its plausible utility to the daily practice of orthopaedic surgeons, represented another focal point. In this sense, the research started from the validation of the 3D assessment of femoral morphometric parameters. Veterinary literature reports tons of papers describing several methodologies for obtaining femoral measurements through different diagnostic techniques. Furthermore, bibliography presents lot of angles values that are currently adopted and considered as reference parameters for most of the corrective osteotomies. Additionally, in the recent past an increased emphasis on 3D approach grown but little if any attention was devoted to 3D measurements. This trend represented in the authors’ mind the gap with the current knowledge and, thus, an area to be deeply investigated. Indeed, to the best of author knowledge, there were no papers documenting the assessment of 3D femoral axes and angles in veterinary medicine, with no 3D protocol described. In addition, currently available canine femoral measurements related to frontal, sagittal and transverse deformities have only been computed in bi-planar projections, whether acquired from 2D or 3D imaging models. Therefore, starting from the accepted human methods and from the features definition in veterinary literature, we proposed a new approach. The first study was designed to define a 3D methodology, introducing a consistent and quantitative method for the assessment of femoral morphometric parameters in 3D geometrical models. To validate the proposed approach, accurate geometric data were necessary and, therefore, we opted for meshes obtained by a 3D scanner, instead of CT images. Once the validation of the was stated, our focus was directed towards the evaluation of the precision of the proposed 3D protocol. The validation of a novel diagnostic test requires verification of the repeatability, defined as the strength of agreement between repeated measurements of the same samples performed from one examiner, and the reproducibility as well, that express the same variance but between a group of observers. Furthermore, the accuracy of the measurements indicates how close the measurements took with the investigated technique to a true value (gold standard). Therefore, a second project was designed to test the precision of three diagnostic techniques, two largely diffuse (Rx and TC) one recently introduced in veterinary (3D), for the measurement of femoral angles. The second purpose of this study was the investigation of the potential application of the algorithm implemented in a computer-aided-design (CAD) software, using CT data. Considering that for the first study we worked with 3D scanner data, the main aim at this point of the research was represented by the enhancement of the presented 3D protocol for diagnostic purposes. In the author opinion, changing the source of data was necessary because of the availability of CT and MRI equipment in veterinary practice. Finally, the last goal of this project was the translation of the application of 3D computation to the surgical field. The current research contemplates the fact that the augmented interest on 3D computation is not only relevant for diagnostic reasons, but also for surgery. Thus, the correlation between the diagnostic utility of the 3D approach and its plausible practice for surgery purposes was the object of the final study. The starting point was suggested by veterinary literature that reports in few papers the development and application of surgical devices used to perform assisted-correction of bone deformities. These surgical tools are designed through 3D geometrical models and act both as precise intraoperative localizers of osteotomy corrective landmarks and surgical saw guides. Three-dimensional assessment of a bone conformation may improve the understanding and evaluation of bone deformities and occurring joints malalignment. In this sense, the localization of the CORA as well as the accuracy of the orientation of the osteotomy-cutting plane may be significantly upgraded through a 3D approach