818 research outputs found

    The neural correlates of emotion regulation by implementation intentions

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    Several studies have investigated the neural basis of effortful emotion regulation (ER) but the neural basis of automatic ER has been less comprehensively explored. The present study investigated the neural basis of automatic ER supported by ‘implementation intentions’. 40 healthy participants underwent fMRI while viewing emotion-eliciting images and used either a previously-taught effortful ER strategy, in the form of a goal intention (e.g., try to take a detached perspective), or a more automatic ER strategy, in the form of an implementation intention (e.g., “If I see something disgusting, then I will think these are just pixels on the screen!”), to regulate their emotional response. Whereas goal intention ER strategies were associated with activation of brain areas previously reported to be involved in effortful ER (including dorsolateral prefrontal cortex), ER strategies based on an implementation intention strategy were associated with activation of right inferior frontal gyrus and ventro-parietal cortex, which may reflect the attentional control processes automatically captured by the cue for action contained within the implementation intention. Goal intentions were also associated with less effective modulation of left amygdala, supporting the increased efficacy of ER under implementation intention instructions, which showed coupling of orbitofrontal cortex and amygdala. The findings support previous behavioural studies in suggesting that forming an implementation intention enables people to enact goal-directed responses with less effort and more efficiency

    Brain Circuitries Involved in Semantic Interference by Demands of Emotional and Non-Emotional Distractors

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    BACKGROUND: Previous studies have indicated that the processes leading to the resolution of emotional and non-emotional interference conflicts are unrelated, involving separate networks. It is also known that conflict resolution itself suggests a considerable overlap of the networks. Our study is an attempt to examine how these findings may be related. METHODOLOGY/PRINCIPAL FINDINGS: We used functional magnetic resonance imaging (fMRI) to study neural responses of 24 healthy subjects to emotional and non-emotional conflict paradigms involving the presentation of congruent and incongruent word-face pairs based on semantic incompatibility between targets and distractors. In the emotional task, the behavioral interference conflict was greater (compared to the non-emotional task) and was paralleled by involvement of the extrastriate visual and posterodorsal medial frontal cortices. In both tasks, we also observed a common network including the dorsal anterior cingulate, the supplemental motor area, the anterior insula and the inferior prefrontal cortex, indicating that these brain structures are markers of experienced conflict. However, the emotional task involved conflict-triggered networks to a considerably higher degree. CONCLUSIONS/SIGNIFICANCE: Our findings indicate that responses to emotional and non-emotional distractors involve the same systems, which are capable of flexible adjustments based on conflict demands. The function of systems related to conflict resolution is likely to be adjusted on the basis of an evaluation process that primarily involves the extrastriate visual cortex, with target playing a significant role

    Deficient prefrontal attentional control in late-life generalized anxiety disorder: an fMRI investigation

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    Younger adults with anxiety disorders are known to show an attentional bias toward negative information. Little is known regarding the role of biased attention in anxious older adults, and even less is known about the neural substrates of any such bias. Functional magnetic resonance imaging (fMRI) was used to assess the mechanisms of attentional bias in late life by contrasting predictions of a top-down model emphasizing deficient prefrontal cortex (PFC) control and a bottom-up model emphasizing amygdalar hyperreactivity. In all, 16 older generalized anxiety disorder (GAD) patients (mean age=66 years) and 12 non-anxious controls (NACs; mean age=67 years) completed the emotional Stroop task to assess selective attention to negative words. Task-related fMRI data were concurrently acquired. Consistent with hypotheses, GAD participants were slower to identify the color of negative words relative to neutral, whereas NACs showed the opposite bias, responding more quickly to negative words. During negative words (in comparison with neutral), the NAC group showed PFC activations, coupled with deactivation of task-irrelevant emotional processing regions such as the amygdala and hippocampus. By contrast, GAD participants showed PFC decreases during negative words and no differences in amygdalar activity across word types. Across all participants, greater attentional bias toward negative words was correlated with decreased PFC recruitment. A significant positive correlation between attentional bias and amygdala activation was also present, but this relationship was mediated by PFC activity. These results are consistent with reduced prefrontal attentional control in late-life GAD. Strategies to enhance top-down attentional control may be particularly relevant in late-life GAD treatment

    Prefrontal inhibition of threat processing reduces working memory interference

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    Bottom-up processes can interrupt ongoing cognitive processing in order to adaptively respond to emotional stimuli of high potential significance, such as those that threaten wellbeing. However it is vital that this interference can be modulated in certain contexts to focus on current tasks. Deficits in the ability to maintain the appropriate balance between cognitive and emotional demands can severely impact on day-to-day activities. This fMRI study examined this interaction between threat processing and cognition; 18 adult participants performed a visuospatial working memory (WM) task with two load conditions, in the presence and absence of anxiety induction by threat of electric shock. Threat of shock interfered with performance in the low cognitive load condition; however interference was eradicated under high load, consistent with engagement of emotion regulation mechanisms. Under low load the amygdala showed significant activation to threat of shock that was modulated by high cognitive load. A directed top-down control contrast identified two regions associated with top-down control; ventrolateral PFC and dorsal ACC. Dynamic causal modeling provided further evidence that under high cognitive load, top-down inhibition is exerted on the amygdala and its outputs to prefrontal regions. Additionally, we hypothesized that individual differences in a separate, non-emotional top-down control task would predict the recruitment of dorsal ACC and ventrolateral PFC during top-down control of threat. Consistent with this, performance on a separate dichotic listening task predicted dorsal ACC and ventrolateral PFC activation during high WM load under threat of shock, though activation in these regions did not directly correlate with WM performance. Together, the findings suggest that under high cognitive load and threat, top-down control is exerted by dACC and vlPFC to inhibit threat processing, thus enabling WM performance without threat-related interference

    Emotional salience but not valence impacts anterior cingulate cortex conflict processing

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    Stimuli that evoke emotions are salient, draw attentional resources, and facilitate situationally appropriate behavior in complex or conflicting environments. However, negative and positive emotions may motivate different response strategies. For example, a threatening stimulus might evoke avoidant behavior, whereas a positive stimulus may prompt approaching behavior. Therefore, emotional stimuli might either elicit differential behavioral responses when a conflict arises or simply mark salience. The present study used functional magnetic resonance imaging to investigate valence-specific emotion effects on attentional control in conflict processing by employing an adapted flanker task with neutral, negative, and positive stimuli. Slower responses were observed for incongruent than congruent trials. Neural activity in the dorsal anterior cingulate cortex was associated with conflict processing regardless of emotional stimulus quality. These findings confirm that both negative and positive emotional stimuli mark salience in both low (congruent) and high (incongruent) conflict scenarios. Regardless of the conflict level, emotional stimuli deployed greater attentional resources in goal directed behavior

    Conscious perception of errors and its relation to the anterior insula

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    To detect erroneous action outcomes is necessary for flexible adjustments and therefore a prerequisite of adaptive, goal-directed behavior. While performance monitoring has been studied intensively over two decades and a vast amount of knowledge on its functional neuroanatomy has been gathered, much less is known about conscious error perception, often referred to as error awareness. Here, we review and discuss the conditions under which error awareness occurs, its neural correlates and underlying functional neuroanatomy. We focus specifically on the anterior insula, which has been shown to be (a) reliably activated during performance monitoring and (b) modulated by error awareness. Anterior insular activity appears to be closely related to autonomic responses associated with consciously perceived errors, although the causality and directions of these relationships still needs to be unraveled. We discuss the role of the anterior insula in generating versus perceiving autonomic responses and as a key player in balancing effortful task-related and resting-state activity. We suggest that errors elicit reactions highly reminiscent of an orienting response and may thus induce the autonomic arousal needed to recruit the required mental and physical resources. We discuss the role of norepinephrine activity in eliciting sufficiently strong central and autonomic nervous responses enabling the necessary adaptation as well as conscious error perception

    The impact of emotional distraction on cognition: from basic brain responses to large-scale network interactions

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    The goal of the current dissertation was to clarify the behavioral and neural mechanisms associated with the impact and control of emotional distraction by investigating the influences of the nature (positive vs. negative) and source (external vs. internal) of emotional distraction, the types of emotion regulation (spontaneous vs. instructed) engaged to cope with it, and the role of sex differences. The present dissertation comprises three studies, with the first two focusing on external emotional distraction, and the third focusing on internal emotional distraction. Study one investigated the roles of arousal and valence in the impact of external emotional distraction on working memory (WM) performance, and yielded four main findings. First, positive distraction had reduced impact on WM performance, compared with negative distraction. Second, fMRI results identified valence-specific effects in a dorsal executive system (DES) and overlapping arousal and valence effects in a ventral affective system (VAS), suggesting both increased impact of negative distraction and enhanced engagement of coping mechanisms for positive distraction. Third, a valence-related rostro-caudal dissociation was identified in medial frontal regions associated with the default-mode network (DMN). Finally, these DMN regions showed increased functional connectivity with DES regions for negative compared with positive distraction. Study two investigated sex differences in the response to external emotional distraction and yielded three main findings. First, an increased impact of emotional distraction among women was detected, in trials associated with high-confidence responses, in the context of overall similar WM performance in women and men. Second, regarding the fMRI results, women showed increased sensitivity to emotional distraction in VAS regions, whereas men showed increased sensitivity in DES regions, in the context of overall similar patterns of response to emotional distraction in women and men. Third, a sex-related dorsal-ventral hemispheric dissociation emerged in the lateral prefrontal cortex (PFC) related to coping with emotional distraction, with women showing a positive correlation with WM performance in left ventral PFC, and men showing similar effects in the right dorsal PFC. Study three investigated the impact and regulation of internal emotional distraction, and yielded four main findings. First, the instructed engagement of emotion regulation (ER) diminished both the subjective negative experience and the objective WM interference. Second, the overall response to internal emotional distraction was linked to deactivation in DES and increased activity in VAS regions, similar to the response to external emotional distraction, as well as with specific increased activity in DMN regions. Third, ER engagement was associated with both diminished activity in VAS regions part of the salience network, and increased activity in executive and memory-related regions. Finally, ER was also associated with increased functional connectivity between fronto-parietal regions. Supplementary, a behavioral pilot study investigated the role of valence and showed that negative but not positive internal distraction interfered with concurrent WM performance. Also, an exploratory analysis tested for sex differences and showed increased impact of internal emotional distraction in women for high-confidence WM performance, linked to increased sensitivity in a medial frontal region associated with the salience network. These findings contribute to a better understanding of healthy functioning under transient emotional distraction. In addition, they have implications for understanding factors linked to increased susceptibility to mood and anxiety disorders, which are afflictions characterized by increased distractibility and altered processing of negative and positive stimuli originating from the external and internal environments, and are more prevalent in women compared to men
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