Precision medicine and artificial intelligence : a pilot study on deep learning for hypoglycemic events detection based on ECG

Tracking the fluctuations in blood glucose levels is important for healthy subjects and crucial diabetic patients. Tight glucose monitoring reduces the risk of hypoglycemia, which can result in a series of complications, especially in diabetic patients, such as confusion, irritability, seizure and can even be fatal in specific conditions. Hypoglycemia affects the electrophysiology of the heart. However, due to strong inter-subject heterogeneity, previous studies based on a cohort of subjects failed to deploy electrocardiogram (ECG)-based hypoglycemic detection systems reliably. The current study used personalised medicine approach and Artificial Intelligence (AI) to automatically detect nocturnal hypoglycemia using a few heartbeats of raw ECG signal recorded with non-invasive, wearable devices, in healthy individuals, monitored 24 hours for 14 consecutive days. Additionally, we present a visualisation method enabling clinicians to visualise which part of the ECG signal (e.g., T-wave, ST-interval) is significantly associated with the hypoglycemic event in each subject, overcoming the intelligibility problem of deep-learning methods. These results advance the feasibility of a real-time, non-invasive hypoglycemia alarming system using short excerpts of ECG signal

Precision medicine and artificial intelligence : a pilot study on deep learning for hypoglycemic events detection based on ECG

Tracking the fluctuations in blood glucose levels is important for healthy subjects and crucial diabetic patients. Tight glucose monitoring reduces the risk of hypoglycemia, which can result in a series of complications, especially in diabetic patients, such as confusion, irritability, seizure and can even be fatal in specific conditions. Hypoglycemia affects the electrophysiology of the heart. However, due to strong inter-subject heterogeneity, previous studies based on a cohort of subjects failed to deploy electrocardiogram (ECG)-based hypoglycemic detection systems reliably. The current study used personalised medicine approach and Artificial Intelligence (AI) to automatically detect nocturnal hypoglycemia using a few heartbeats of raw ECG signal recorded with non-invasive, wearable devices, in healthy individuals, monitored 24 hours for 14 consecutive days. Additionally, we present a visualisation method enabling clinicians to visualise which part of the ECG signal (e.g., T-wave, ST-interval) is significantly associated with the hypoglycemic event in each subject, overcoming the intelligibility problem of deep-learning methods. These results advance the feasibility of a real-time, non-invasive hypoglycemia alarming system using short excerpts of ECG signal

Visual Concepts and Compositional Voting

It is very attractive to formulate vision in terms of pattern theory \cite{Mumford2010pattern}, where patterns are defined hierarchically by compositions of elementary building blocks. But applying pattern theory to real world images is currently less successful than discriminative methods such as deep networks. Deep networks, however, are black-boxes which are hard to interpret and can easily be fooled by adding occluding objects. It is natural to wonder whether by better understanding deep networks we can extract building blocks which can be used to develop pattern theoretic models. This motivates us to study the internal representations of a deep network using vehicle images from the PASCAL3D+ dataset. We use clustering algorithms to study the population activities of the features and extract a set of visual concepts which we show are visually tight and correspond to semantic parts of vehicles. To analyze this we annotate these vehicles by their semantic parts to create a new dataset, VehicleSemanticParts, and evaluate visual concepts as unsupervised part detectors. We show that visual concepts perform fairly well but are outperformed by supervised discriminative methods such as Support Vector Machines (SVM). We next give a more detailed analysis of visual concepts and how they relate to semantic parts. Following this, we use the visual concepts as building blocks for a simple pattern theoretical model, which we call compositional voting. In this model several visual concepts combine to detect semantic parts. We show that this approach is significantly better than discriminative methods like SVM and deep networks trained specifically for semantic part detection. Finally, we return to studying occlusion by creating an annotated dataset with occlusion, called VehicleOcclusion, and show that compositional voting outperforms even deep networks when the amount of occlusion becomes large.Comment: It is accepted by Annals of Mathematical Sciences and Application

Active learning of an action detector on untrimmed videos

textCollecting and annotating videos of realistic human actions is tedious, yet critical for training action recognition systems. We propose a method to actively request the most useful video annotations among a large set of unlabeled videos. Predicting the utility of annotating unlabeled video is not trivial, since any given clip may contain multiple actions of interest, and it need not be trimmed to temporal regions of interest. To deal with this problem, we propose a detection-based active learner to train action category models. We develop a voting-based framework to localize likely intervals of interest in an unlabeled clip, and use them to estimate the total reduction in uncertainty that annotating that clip would yield. On three datasets, we show our approach can learn accurate action detectors more efficiently than alternative active learning strategies that fail to accommodate the "untrimmed" nature of real video data.Computer Science

Two-Stream RNN/CNN for Action Recognition in 3D Videos

The recognition of actions from video sequences has many applications in health monitoring, assisted living, surveillance, and smart homes. Despite advances in sensing, in particular related to 3D video, the methodologies to process the data are still subject to research. We demonstrate superior results by a system which combines recurrent neural networks with convolutional neural networks in a voting approach. The gated-recurrent-unit-based neural networks are particularly well-suited to distinguish actions based on long-term information from optical tracking data; the 3D-CNNs focus more on detailed, recent information from video data. The resulting features are merged in an SVM which then classifies the movement. In this architecture, our method improves recognition rates of state-of-the-art methods by 14% on standard data sets.Comment: Published in 2017 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS

Increasing robustness of pairwise methods for effective connectivity in Magnetic Resonance Imaging by using fractional moment series of BOLD signal distributions

Estimating causal interactions in the brain from functional magnetic resonance imaging (fMRI) data remains a challenging task. Multiple studies have demonstrated that all current approaches to determine direction of connectivity perform poorly even when applied to synthetic fMRI datasets. Recent advances in this field include methods for pairwise inference, which involve creating a sparse connectome in the first step, and then using a classifier in order to determine the directionality of connection between of every pair of nodes in the second step. In this work, we introduce an advance to the second step of this procedure, by building a classifier based on fractional moments of the BOLD distribution combined into cumulants. The classifier is trained on datasets generated under the Dynamic Causal Modeling (DCM) generative model. The directionality is inferred based upon statistical dependencies between the two node time series, e.g. assigning a causal link from time series of low variance to time series of high variance. Our approach outperforms or performs as well as other methods for effective connectivity when applied to the benchmark datasets. Crucially, it is also more resilient to confounding effects such as differential noise level across different areas of the connectome.Comment: 41 pages, 12 figure

Detecting Semantic Parts on Partially Occluded Objects

In this paper, we address the task of detecting semantic parts on partially occluded objects. We consider a scenario where the model is trained using non-occluded images but tested on occluded images. The motivation is that there are infinite number of occlusion patterns in real world, which cannot be fully covered in the training data. So the models should be inherently robust and adaptive to occlusions instead of fitting / learning the occlusion patterns in the training data. Our approach detects semantic parts by accumulating the confidence of local visual cues. Specifically, the method uses a simple voting method, based on log-likelihood ratio tests and spatial constraints, to combine the evidence of local cues. These cues are called visual concepts, which are derived by clustering the internal states of deep networks. We evaluate our voting scheme on the VehicleSemanticPart dataset with dense part annotations. We randomly place two, three or four irrelevant objects onto the target object to generate testing images with various occlusions. Experiments show that our algorithm outperforms several competitors in semantic part detection when occlusions are present.Comment: Accepted to BMVC 2017 (13 pages, 3 figures