Improving High Resolution Histology Image Classification with Deep Spatial Fusion Network

Histology imaging is an essential diagnosis method to finalize the grade and stage of cancer of different tissues, especially for breast cancer diagnosis. Specialists often disagree on the final diagnosis on biopsy tissue due to the complex morphological variety. Although convolutional neural networks (CNN) have advantages in extracting discriminative features in image classification, directly training a CNN on high resolution histology images is computationally infeasible currently. Besides, inconsistent discriminative features often distribute over the whole histology image, which incurs challenges in patch-based CNN classification method. In this paper, we propose a novel architecture for automatic classification of high resolution histology images. First, an adapted residual network is employed to explore hierarchical features without attenuation. Second, we develop a robust deep fusion network to utilize the spatial relationship between patches and learn to correct the prediction bias generated from inconsistent discriminative feature distribution. The proposed method is evaluated using 10-fold cross-validation on 400 high resolution breast histology images with balanced labels and reports 95% accuracy on 4-class classification and 98.5% accuracy, 99.6% AUC on 2-class classification (carcinoma and non-carcinoma), which substantially outperforms previous methods and close to pathologist performance.Comment: 8 pages, MICCAI workshop preceeding

Learning Spatiotemporal Features for Infrared Action Recognition with 3D Convolutional Neural Networks

Infrared (IR) imaging has the potential to enable more robust action recognition systems compared to visible spectrum cameras due to lower sensitivity to lighting conditions and appearance variability. While the action recognition task on videos collected from visible spectrum imaging has received much attention, action recognition in IR videos is significantly less explored. Our objective is to exploit imaging data in this modality for the action recognition task. In this work, we propose a novel two-stream 3D convolutional neural network (CNN) architecture by introducing the discriminative code layer and the corresponding discriminative code loss function. The proposed network processes IR image and the IR-based optical flow field sequences. We pretrain the 3D CNN model on the visible spectrum Sports-1M action dataset and finetune it on the Infrared Action Recognition (InfAR) dataset. To our best knowledge, this is the first application of the 3D CNN to action recognition in the IR domain. We conduct an elaborate analysis of different fusion schemes (weighted average, single and double-layer neural nets) applied to different 3D CNN outputs. Experimental results demonstrate that our approach can achieve state-of-the-art average precision (AP) performances on the InfAR dataset: (1) the proposed two-stream 3D CNN achieves the best reported 77.5% AP, and (2) our 3D CNN model applied to the optical flow fields achieves the best reported single stream 75.42% AP

No Spare Parts: Sharing Part Detectors for Image Categorization

This work aims for image categorization using a representation of distinctive parts. Different from existing part-based work, we argue that parts are naturally shared between image categories and should be modeled as such. We motivate our approach with a quantitative and qualitative analysis by backtracking where selected parts come from. Our analysis shows that in addition to the category parts defining the class, the parts coming from the background context and parts from other image categories improve categorization performance. Part selection should not be done separately for each category, but instead be shared and optimized over all categories. To incorporate part sharing between categories, we present an algorithm based on AdaBoost to jointly optimize part sharing and selection, as well as fusion with the global image representation. We achieve results competitive to the state-of-the-art on object, scene, and action categories, further improving over deep convolutional neural networks

Patch-based Convolutional Neural Network for Whole Slide Tissue Image Classification

Convolutional Neural Networks (CNN) are state-of-the-art models for many image classification tasks. However, to recognize cancer subtypes automatically, training a CNN on gigapixel resolution Whole Slide Tissue Images (WSI) is currently computationally impossible. The differentiation of cancer subtypes is based on cellular-level visual features observed on image patch scale. Therefore, we argue that in this situation, training a patch-level classifier on image patches will perform better than or similar to an image-level classifier. The challenge becomes how to intelligently combine patch-level classification results and model the fact that not all patches will be discriminative. We propose to train a decision fusion model to aggregate patch-level predictions given by patch-level CNNs, which to the best of our knowledge has not been shown before. Furthermore, we formulate a novel Expectation-Maximization (EM) based method that automatically locates discriminative patches robustly by utilizing the spatial relationships of patches. We apply our method to the classification of glioma and non-small-cell lung carcinoma cases into subtypes. The classification accuracy of our method is similar to the inter-observer agreement between pathologists. Although it is impossible to train CNNs on WSIs, we experimentally demonstrate using a comparable non-cancer dataset of smaller images that a patch-based CNN can outperform an image-based CNN