Perfect simulation, monotonicity and finite queueing networks

International audienceTutorial on perfect sampling with applications to queueing network

Synthesis and Stochastic Assessment of Cost-Optimal Schedules

We present a novel approach to synthesize good schedules for a class of scheduling problems that is slightly more general than the scheduling problem FJm,a|gpr,r_j,d_j|early/tardy. The idea is to prime the schedule synthesizer with stochastic information more meaningful than performance factors with the objective to minimize the expected cost caused by storage or delay. The priming information is obtained by stochastic simulation of the system environment. The generated schedules are assessed again by simulation. The approach is demonstrated by means of a non-trivial scheduling problem from lacquer production. The experimental results show that our approach achieves in all considered scenarios better results than the extended processing times approach

Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway as a Case Study

The last decade has seen an explosion in models that describe phenomena in systems medicine. Such models are especially useful for studying signaling pathways, such as the Wnt pathway. In this chapter we use the Wnt pathway to showcase current mathematical and statistical techniques that enable modelers to gain insight into (models of) gene regulation, and generate testable predictions. We introduce a range of modeling frameworks, but focus on ordinary differential equation (ODE) models since they remain the most widely used approach in systems biology and medicine and continue to offer great potential. We present methods for the analysis of a single model, comprising applications of standard dynamical systems approaches such as nondimensionalization, steady state, asymptotic and sensitivity analysis, and more recent statistical and algebraic approaches to compare models with data. We present parameter estimation and model comparison techniques, focusing on Bayesian analysis and coplanarity via algebraic geometry. Our intention is that this (non exhaustive) review may serve as a useful starting point for the analysis of models in systems medicine.Comment: Submitted to 'Systems Medicine' as a book chapte