The mathematical research of William Parry FRS

In this article we survey the mathematical research of the late William (Bill) Parry, FRS

A Polynomial Spectral Calculus for Analysis of DG Spectral Element Methods

We introduce a polynomial spectral calculus that follows from the summation by parts property of the Legendre-Gauss-Lobatto quadrature. We use the calculus to simplify the analysis of two multidimensional discontinuous Galerkin spectral element approximations

Covariance estimation using conjugate gradient for 3D classification in Cryo-EM

Classifying structural variability in noisy projections of biological macromolecules is a central problem in Cryo-EM. In this work, we build on a previous method for estimating the covariance matrix of the three-dimensional structure present in the molecules being imaged. Our proposed method allows for incorporation of contrast transfer function and non-uniform distribution of viewing angles, making it more suitable for real-world data. We evaluate its performance on a synthetic dataset and an experimental dataset obtained by imaging a 70S ribosome complex