8,384 research outputs found
The ghost of the âYâ : paternal DNA, haunting and genealogy
Based on a personal family history experience, in this paper, I consider the way in which genealogical DNA testing is revealing family secrets, in particular paternity secrets, which would previously have remained unknown via âtraditionalâ methods of genealogical research. Reasons for the displacement of these invisible fathers from the records are discussed, and the power of genealogical DNA testing to bring them into focus is examined. Such discoveries may disrupt and unsettle, causing people to think differently about the fathers and grandfathers with whom they have grown up or have believed to be part of their personal histories and, for some people, may challenge their sense of identity. Beyond personal identity issues, in this paper, I draw upon ideas about âghost-workâ to suggest that these experiences have some of the features of hauntings and that the ghostly fathers who break through may speak to us about social realities and structures, beyond the confines of linear tim
W. M. Keck Foundation - 2008 Annual Report: Discovery
Contains board chair's message, program highlights, grantee profiles, grants list, financial statements, and lists of board members and committee members
Prospect patents, data markets, and the commons in data-driven medicine : openness and the political economy of intellectual property rights
Scholars who point to political influences and the regulatory function of patent courts in the USA have long questioned the courtsâ subjective interpretation of what âthingsâ can be claimed as inventions. The present article sheds light on a different but related facet: the role of the courts in regulating knowledge production. I argue that the recent cases decided by the US Supreme Court and the Federal Circuit, which made diagnostics and software very difficult to patent and which attracted criticism for a wealth of different reasons, are fine case studies of the current debate over the proper role of the state in regulating the marketplace and knowledge production in the emerging information economy. The article explains that these patents are prospect patents that may be used by a monopolist to collect data that everybody else needs in order to compete effectively. As such, they raise familiar concerns about failure of coordination emerging as a result of a monopolist controlling a resource such as datasets that others need and cannot replicate. In effect, the courts regulated the market, primarily focusing on ensuring the free flow of data in the emerging marketplace very much in the spirit of the âfree the dataâ language in various policy initiatives, yet at the same time with an eye to boost downstream innovation. In doing so, these decisions essentially endorse practices of personal information processing which constitute a new type of public domain: a source of raw materials which are there for the taking and which have become most important inputs to commercial activity. From this vantage point of view, the legal interpretation of the private and the shared legitimizes a model of data extraction from individuals, the raw material of information capitalism, that will fuel the next generation of data-intensive therapeutics in the field of data-driven medicine
Quantum fluctuations and life
There have been many claims that quantum mechanics plays a key role in the
origin and/or operation of biological organisms, beyond merely providing the
basis for the shapes and sizes of biological molecules and their chemical
affinities. These range from the suggestion by Schrodinger that quantum
fluctuations produce mutations, to the conjecture by Hameroff and Penrose that
quantum coherence in microtubules is linked to consciousness. I review some of
these claims in this paper, and discuss the serious problem of decoherence. I
advance some further conjectures about quantum information processing in
bio-systems. Some possible experiments are suggested.Comment: 10 pages, no figures, conference pape
Behavioral Genetics Research and Criminal DNA Databases
Kaye discusses DNA databanks and the potential use of such databanks for behavioral genetics research. He addresses the concern that DNA databanks serve as a limitless repository for future research and that the samples used in the databanks could be used for research into a crime gene
From metagenomics to the metagenome: Conceptual change and the rhetoric of translational genomic research
As the international genomic research community moves from the tool-making efforts of the Human Genome Project into biomedical applications of those tools, new metaphors are being suggested as useful to understanding how our genes work â and for understanding who we are as biological organisms. In this essay we focus on the Human Microbiome Project as one such translational initiative. The HMP is a new âmetagenomicâ research effort to sequence the genomes of human microbiological flora, in order to pursue the interesting hypothesis that our âmicrobiomeâ plays a vital and interactive role with our human genome in normal human physiology. Rather than describing the human genome as the âblueprintâ for human nature, the promoters of the HMP stress the ways in which our primate lineage DNA is interdependent with the genomes of our microbiological flora. They argue that the human body should be understood as an ecosystem with multiple ecological niches and habitats in which a variety of cellular species collaborate and compete, and that human beings should be understood as âsuperorganismsâ that incorporate multiple symbiotic cell species into a single individual with very blurry boundaries. These metaphors carry interesting philosophical messages, but their inspiration is not entirely ideological. Instead, part of their cachet within genome science stems from the ways in which they are rooted in genomic research techniques, in what philosophers of science have called a âtools-to-theoryâ heuristic. Their emergence within genome science illustrates the complexity of conceptual change in translational research, by showing how it reflects both aspirational and methodological influences
Manufacturing Barriers to Biologics Competition and Innovation
As finding breakthrough small-molecule drugs gets harder, drug companies are increasingly turning to âlarge moleculeâ biologics. Although biologics represent many of the most promising new therapies for previously intractable diseases, they are extremely expensive. Moreover, the pathway for generic-type competition set up by Congress in 2010 is unlikely to yield significant cost savings.
In this Article, we provide a fresh diagnosis of, and prescription for, this major public policy problem. We argue that the key cause is pervasive trade secrecy in the complex area of biologics manufacturing. Under the current regime, this trade secrecy, combined with certain features of FDA regulation, not only creates high barriers to entry of indefinite duration but also undermines efforts to advance fundamental knowledge.
In sharp contrast, offering incentives for information disclosure to originator manufacturers would leverage the existing interaction of trade secrecy and the regulatory state in a positive direction. Although trade secrecy, particularly in complex areas like biologics manufacturing, often involves tacit knowledge that is difficult to codify and thus transfer, in this case regulatory requirements that originator manufacturers submit manufacturing details have already codified the relevant tacit knowledge. Incentivizing disclosure of these regulatory submissions would not only spur competition but it would provide a rich source of information upon which additional research, including fundamental research into the science of manufacturing, could build.
In addition to provide fresh diagnosis and prescription in the specific area of biologics, the Article contributes to more general scholarship on trade secrecy and tacit knowledge. Prior scholarship has neglected the extent to which regulation can turn tacit knowledge not only into codified knowledge but into precisely the type of codified knowledge that is most likely to be useful and accurate. The Article also draws a link to the literature on adaptive regulation, arguing that greater regulatory flexibility is necessary and that more fundamental knowledge should spur flexibility.
A vastly shortened version of the central argument that manufacturing trade secrecy hampers biosimilar development was published at 348 Science 188 (2015), available online
Routes for breaching and protecting genetic privacy
We are entering the era of ubiquitous genetic information for research,
clinical care, and personal curiosity. Sharing these datasets is vital for
rapid progress in understanding the genetic basis of human diseases. However,
one growing concern is the ability to protect the genetic privacy of the data
originators. Here, we technically map threats to genetic privacy and discuss
potential mitigation strategies for privacy-preserving dissemination of genetic
data.Comment: Draft for comment
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