987 research outputs found
Multi-objective optimization based network control principles for identifying personalized drug targets with cancer
It is a big challenge to develop efficient models for identifying
personalized drug targets (PDTs) from high-dimensional personalized genomic
profile of individual patients. Recent structural network control principles
have introduced a new approach to discover PDTs by selecting an optimal set of
driver genes in personalized gene interaction network (PGIN). However, most of
current methods only focus on controlling the system through a minimum
driver-node set and ignore the existence of multiple candidate driver-node sets
for therapeutic drug target identification in PGIN. Therefore, this paper
proposed multi-objective optimization-based structural network control
principles (MONCP) by considering minimum driver nodes and maximum prior-known
drug-target information. To solve MONCP, a discrete multi-objective
optimization problem is formulated with many constrained variables, and a novel
evolutionary optimization model called LSCV-MCEA was developed by adapting a
multi-tasking framework and a rankings-based fitness function method. With
genomics data of patients with breast or lung cancer from The Cancer Genome
Atlas database, the effectiveness of LSCV-MCEA was validated. The experimental
results indicated that compared with other advanced methods, LSCV-MCEA can more
effectively identify PDTs with the highest Area Under the Curve score for
predicting clinically annotated combinatorial drugs. Meanwhile, LSCV-MCEA can
more effectively solve MONCP than other evolutionary optimization methods in
terms of algorithm convergence and diversity. Particularly, LSCV-MCEA can
efficiently detect disease signals for individual patients with BRCA cancer.
The study results show that multi-objective optimization can solve structural
network control principles effectively and offer a new perspective for
understanding tumor heterogeneity in cancer precision medicine.Comment: 15 pages, 8 figures; This work has been submitted to IEEE
Transactions on Evolutionary Computatio
Enhancing the predictive performance of ensemble models through novel multi-objective strategies: evidence from credit risk and business model innovation survey data
This paper proposes novel multi-objective optimization strategies to develop a weighted
ensemble model. The comparison of the performance of the proposed strategies against
simulated data suggests that the multi-objective strategy based on joint entropy is superior
to other proposed strategies. For the application, generalization, and practical implications
of the proposed approaches, we implemented the model on two real datasets related to the
prediction of credit risk default and the adoption of the innovative business model by firms.
The scope of this paper can be extended in ordering the solutions of the proposed multi-
objective strategies and can be generalized for other similar predictive task
GALAXY: A new hybrid MOEA for the Optimal Design of Water Distribution Systems
This is the final version of the article. Available from American Geophysical Union via the DOI in this record.The first author would like to appreciate the financial support given by both the University of Exeter and the China Scholarship Council (CSC) toward the PhD research. We also appreciate the three anonymous reviewers, who help improve the quality of this paper substantially. The source code of the latest versions of NSGA-II and ε-MOEA can be downloaded from the official website of Kanpur Genetic Algorithms Laboratory via http://www.iitk.ac.in/kangal/codes.shtml. The description of each benchmark problem used in this paper, including the input file of EPANET and the associated best-known Pareto front, can be accessed from the following link to the Centre for Water Systems (http://tinyurl.com/cwsbenchmarks/). GALAXY can be accessed via http://tinyurl.com/cws-galaxy
Multiobjective Optimization of Non-Smooth PDE-Constrained Problems
Multiobjective optimization plays an increasingly important role in modern
applications, where several criteria are often of equal importance. The task in
multiobjective optimization and multiobjective optimal control is therefore to
compute the set of optimal compromises (the Pareto set) between the conflicting
objectives. The advances in algorithms and the increasing interest in
Pareto-optimal solutions have led to a wide range of new applications related
to optimal and feedback control - potentially with non-smoothness both on the
level of the objectives or in the system dynamics. This results in new
challenges such as dealing with expensive models (e.g., governed by partial
differential equations (PDEs)) and developing dedicated algorithms handling the
non-smoothness. Since in contrast to single-objective optimization, the Pareto
set generally consists of an infinite number of solutions, the computational
effort can quickly become challenging, which is particularly problematic when
the objectives are costly to evaluate or when a solution has to be presented
very quickly. This article gives an overview of recent developments in the
field of multiobjective optimization of non-smooth PDE-constrained problems. In
particular we report on the advances achieved within Project 2 "Multiobjective
Optimization of Non-Smooth PDE-Constrained Problems - Switches, State
Constraints and Model Order Reduction" of the DFG Priority Programm 1962
"Non-smooth and Complementarity-based Distributed Parameter Systems: Simulation
and Hierarchical Optimization"
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