Substructure Discovery Using Minimum Description Length and Background Knowledge

The ability to identify interesting and repetitive substructures is an essential component to discovering knowledge in structural data. We describe a new version of our SUBDUE substructure discovery system based on the minimum description length principle. The SUBDUE system discovers substructures that compress the original data and represent structural concepts in the data. By replacing previously-discovered substructures in the data, multiple passes of SUBDUE produce a hierarchical description of the structural regularities in the data. SUBDUE uses a computationally-bounded inexact graph match that identifies similar, but not identical, instances of a substructure and finds an approximate measure of closeness of two substructures when under computational constraints. In addition to the minimum description length principle, other background knowledge can be used by SUBDUE to guide the search towards more appropriate substructures. Experiments in a variety of domains demonstrate SUBDUE's ability to find substructures capable of compressing the original data and to discover structural concepts important to the domain. Description of Online Appendix: This is a compressed tar file containing the SUBDUE discovery system, written in C. The program accepts as input databases represented in graph form, and will output discovered substructures with their corresponding value.Comment: See http://www.jair.org/ for an online appendix and other files accompanying this articl

From data towards knowledge: Revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data

Genetic and pharmacological perturbation experiments, such as deleting a gene and monitoring gene expression responses, are powerful tools for studying cellular signal transduction pathways. However, it remains a challenge to automatically derive knowledge of a cellular signaling system at a conceptual level from systematic perturbation-response data. In this study, we explored a framework that unifies knowledge mining and data mining approaches towards the goal. The framework consists of the following automated processes: 1) applying an ontology-driven knowledge mining approach to identify functional modules among the genes responding to a perturbation in order to reveal potential signals affected by the perturbation; 2) applying a graph-based data mining approach to search for perturbations that affect a common signal with respect to a functional module, and 3) revealing the architecture of a signaling system organize signaling units into a hierarchy based on their relationships. Applying this framework to a compendium of yeast perturbation-response data, we have successfully recovered many well-known signal transduction pathways; in addition, our analysis have led to many hypotheses regarding the yeast signal transduction system; finally, our analysis automatically organized perturbed genes as a graph reflecting the architect of the yeast signaling system. Importantly, this framework transformed molecular findings from a gene level to a conceptual level, which readily can be translated into computable knowledge in the form of rules regarding the yeast signaling system, such as "if genes involved in MAPK signaling are perturbed, genes involved in pheromone responses will be differentially expressed"

Artifact Lifecycle Discovery

Artifact-centric modeling is a promising approach for modeling business processes based on the so-called business artifacts - key entities driving the company's operations and whose lifecycles define the overall business process. While artifact-centric modeling shows significant advantages, the overwhelming majority of existing process mining methods cannot be applied (directly) as they are tailored to discover monolithic process models. This paper addresses the problem by proposing a chain of methods that can be applied to discover artifact lifecycle models in Guard-Stage-Milestone notation. We decompose the problem in such a way that a wide range of existing (non-artifact-centric) process discovery and analysis methods can be reused in a flexible manner. The methods presented in this paper are implemented as software plug-ins for ProM, a generic open-source framework and architecture for implementing process mining tools

Structure induction by lossless graph compression

This work is motivated by the necessity to automate the discovery of structure in vast and evergrowing collection of relational data commonly represented as graphs, for example genomic networks. A novel algorithm, dubbed Graphitour, for structure induction by lossless graph compression is presented and illustrated by a clear and broadly known case of nested structure in a DNA molecule. This work extends to graphs some well established approaches to grammatical inference previously applied only to strings. The bottom-up graph compression problem is related to the maximum cardinality (non-bipartite) maximum cardinality matching problem. The algorithm accepts a variety of graph types including directed graphs and graphs with labeled nodes and arcs. The resulting structure could be used for representation and classification of graphs.Comment: 10 pages, 7 figures, 2 tables published in Proceedings of the Data Compression Conference, 200

Distributed Computation as Hierarchy

This paper presents a new distributed computational model of distributed systems called the phase web that extends V. Pratt's orthocurrence relation from 1986. The model uses mutual-exclusion to express sequence, and a new kind of hierarchy to replace event sequences, posets, and pomsets. The model explicitly connects computation to a discrete Clifford algebra that is in turn extended into homology and co-homology, wherein the recursive nature of objects and boundaries becomes apparent and itself subject to hierarchical recursion. Topsy, a programming environment embodying the phase web, is available from www.cs.auc.dk/topsy.Comment: 16 pages, 3 figure

Building XML data warehouse based on frequent patterns in user queries

[Abstract]: With the proliferation of XML-based data sources available across the Internet, it is increasingly important to provide users with a data warehouse of XML data sources to facilitate decision-making processes. Due to the extremely large amount of XML data available on web, unguided warehousing of XML data turns out to be highly costly and usually cannot well accommodate the users’ needs in XML data acquirement. In this paper, we propose an approach to materialize XML data warehouses based on frequent query patterns discovered from historical queries issued by users. The schemas of integrated XML documents in the warehouse are built using these frequent query patterns represented as Frequent Query Pattern Trees (FreqQPTs). Using hierarchical clustering technique, the integration approach in the data warehouse is flexible with respect to obtaining and maintaining XML documents. Experiments show that the overall processing of the same queries issued against the global schema become much efficient by using the XML data warehouse built than by directly searching the multiple data sources