Designer cell signal processing circuits for biotechnology

Microorganisms are able to respond effectively to diverse signals from their environment and internal metabolism owing to their inherent sophisticated information processing capacity. A central aim of synthetic biology is to control and reprogramme the signal processing pathways within living cells so as to realise repurposed, beneficial applications ranging from disease diagnosis and environmental sensing to chemical bioproduction. To date most examples of synthetic biological signal processing have been built based on digital information flow, though analogue computing is being developed to cope with more complex operations and larger sets of variables. Great progress has been made in expanding the categories of characterised biological components that can be used for cellular signal manipulation, thereby allowing synthetic biologists to more rationally programme increasingly complex behaviours into living cells. Here we present a current overview of the components and strategies that exist for designer cell signal processing and decision making, discuss how these have been implemented in prototype systems for therapeutic, environmental, and industrial biotechnological applications, and examine emerging challenges in this promising field

Signal processing for a laser-Doppler blood perfusion meter

Two signal processing methods for laser-Dopper perfusion velocimetry are presented. The methods are based on the calculation of the moments of the frequency power spectrum. The first uses Vω-filtering (ω is the frequency) with analogous electronics, the second uses signal autocorrelation with digital electronics. Comparison is made with a third instrument: a spectrum analyzer coupled to a computer, using Fourier transform tecniques. The performance of these setups (sensitivity, limit sensitivity and accuracy) are investigated. We propose a calibration standard for signal processors to be used for blood perfusion measurements. The analogous instrument proved to be the cheapest but the digital instrument had the best performance

An M-QAM Signal Modulation Recognition Algorithm in AWGN Channel

Computing the distinct features from input data, before the classification, is a part of complexity to the methods of Automatic Modulation Classification (AMC) which deals with modulation classification was a pattern recognition problem. Although the algorithms that focus on MultiLevel Quadrature Amplitude Modulation (M-QAM) which underneath different channel scenarios was well detailed. A search of the literature revealed indicates that few studies were done on the classification of high order M-QAM modulation schemes like128-QAM, 256-QAM, 512-QAM and1024-QAM. This work is focusing on the investigation of the powerful capability of the natural logarithmic properties and the possibility of extracting Higher-Order Cumulant's (HOC) features from input data received raw. The HOC signals were extracted under Additive White Gaussian Noise (AWGN) channel with four effective parameters which were defined to distinguished the types of modulation from the set; 4-QAM~1024-QAM. This approach makes the recognizer more intelligent and improves the success rate of classification. From simulation results, which was achieved under statistical models for noisy channels, manifest that recognized algorithm executes was recognizing in M-QAM, furthermore, most results were promising and showed that the logarithmic classifier works well over both AWGN and different fading channels, as well as it can achieve a reliable recognition rate even at a lower signal-to-noise ratio (less than zero), it can be considered as an Integrated Automatic Modulation Classification (AMC) system in order to identify high order of M-QAM signals that applied a unique logarithmic classifier, to represents higher versatility, hence it has a superior performance via all previous works in automatic modulation identification systemComment: 18 page

A Review of Atrial Fibrillation Detection Methods as a Service

Atrial Fibrillation (AF) is a common heart arrhythmia that often goes undetected, and even if it is detected, managing the condition may be challenging. In this paper, we review how the RR interval and Electrocardiogram (ECG) signals, incorporated into a monitoring system, can be useful to track AF events. Were such an automated system to be implemented, it could be used to help manage AF and thereby reduce patient morbidity and mortality. The main impetus behind the idea of developing a service is that a greater data volume analyzed can lead to better patient outcomes. Based on the literature review, which we present herein, we introduce the methods that can be used to detect AF efficiently and automatically via the RR interval and ECG signals. A cardiovascular disease monitoring service that incorporates one or multiple of these detection methods could extend event observation to all times, and could therefore become useful to establish any AF occurrence. The development of an automated and efficient method that monitors AF in real time would likely become a key component for meeting public health goals regarding the reduction of fatalities caused by the disease. Yet, at present, significant technological and regulatory obstacles remain, which prevent the development of any proposed system. Establishment of the scientific foundation for monitoring is important to provide effective service to patients and healthcare professionals

Mapping our Universe in 3D with MITEoR

Mapping our universe in 3D by imaging the redshifted 21 cm line from neutral hydrogen has the potential to overtake the cosmic microwave background as our most powerful cosmological probe, because it can map a much larger volume of our Universe, shedding new light on the epoch of reionization, inflation, dark matter, dark energy, and neutrino masses. We report on MITEoR, a pathfinder low-frequency radio interferometer whose goal is to test technologies that greatly reduce the cost of such 3D mapping for a given sensitivity. MITEoR accomplishes this by using massive baseline redundancy both to enable automated precision calibration and to cut the correlator cost scaling from N^2 to NlogN, where N is the number of antennas. The success of MITEoR with its 64 dual-polarization elements bodes well for the more ambitious HERA project, which would incorporate many identical or similar technologies using an order of magnitude more antennas, each with dramatically larger collecting area.Comment: To be published in proceedings of 2013 IEEE International Symposium on Phased Array Systems & Technolog

A Novel Adaptive Spectrum Noise Cancellation Approach for Enhancing Heartbeat Rate Monitoring in a Wearable Device

This paper presents a novel approach, Adaptive Spectrum Noise Cancellation (ASNC), for motion artifacts removal in Photoplethysmography (PPG) signals measured by an optical biosensor to obtain clean PPG waveforms for heartbeat rate calculation. One challenge faced by this optical sensing method is the inevitable noise induced by movement when the user is in motion, especially when the motion frequency is very close to the target heartbeat rate. The proposed ASNC utilizes the onboard accelerometer and gyroscope sensors to detect and remove the artifacts adaptively, thus obtaining accurate heartbeat rate measurement while in motion. The ASNC algorithm makes use of a commonly accepted spectrum analysis approaches in medical digital signal processing, discrete cosine transform, to carry out frequency domain analysis. Results obtained by the proposed ASNC have been compared to the classic algorithms, the adaptive threshold peak detection and adaptive noise cancellation. The mean (standard deviation) absolute error and mean relative error of heartbeat rate calculated by ASNC is 0.33 (0.57) beats·min-1 and 0.65%, by adaptive threshold peak detection algorithm is 2.29 (2.21) beats·min-1 and 8.38%, by adaptive noise cancellation algorithm is 1.70 (1.50) beats·min-1 and 2.02%. While all algorithms performed well with both simulated PPG data and clean PPG data collected from our Verity device in situations free of motion artifacts, ASNC provided better accuracy when motion artifacts increase, especially when motion frequency is very close to the heartbeat rate