1,304 research outputs found
Registration of low-SNR high-resolution diffusion-weighted images
This paper introduces a novel, high-speed scheme for intrasubject registration and segmentation of high-resolution multi-shot diffusion-weighted images.
Compared to single-shot sequences, multi-shot have advantages in terms of improved spatial resolution and reduced eddy-current and susceptibility artifacts.
However, these sequences have prolonged scan times increasing the risk of subject motion, and, a lower signal to noise ratio (SNR) with smaller voxel volumes.
The proposed registration algorithm comprises a hybrid thresholding expectation-maximization segmentation method that can cope with the low-SNR, and registers diffusion-weighted to B0 images through fast detection and matching
of features found in edge images derived from floating and reference images.
We performed validations of the entire pipeline, including assessment of visual appearance by experts, consistency error computations, and analysis of the segmentation, using volunteer images, and found its performance to be comparable
with, or exceeding, that of established solutions
Three-dimensional echo-shifted EPI with simultaneous blip-up and blip-down acquisitions for correcting geometric distortion
Purpose: Echo-planar imaging (EPI) with blip-up/down acquisition (BUDA) can
provide high-quality images with minimal distortions by using two readout
trains with opposing phase-encoding gradients. Because of the need for two
separate acquisitions, BUDA doubles the scan time and degrades the temporal
resolution when compared to single-shot EPI, presenting a major challenge for
many applications, particularly functional MRI (fMRI). This study aims at
overcoming this challenge by developing an echo-shifted EPI BUDA (esEPI-BUDA)
technique to acquire both blip-up and blip-down datasets in a single shot.
Methods: A three-dimensional (3D) esEPI-BUDA pulse sequence was designed by
using an echo-shifting strategy to produce two EPI readout trains. These
readout trains produced a pair of k-space datasets whose k-space trajectories
were interleaved with opposite phase-encoding gradient directions. The two
k-space datasets were separately reconstructed using a 3D SENSE algorithm, from
which time-resolved B0-field maps were derived using TOPUP in FSL and then
input into a forward model of joint parallel imaging reconstruction to correct
for geometric distortion. In addition, Hankel structured low-rank constraint
was incorporated into the reconstruction framework to improve image quality by
mitigating the phase errors between the two interleaved k-space datasets.
Results: The 3D esEPI-BUDA technique was demonstrated in a phantom and an fMRI
study on healthy human subjects. Geometric distortions were effectively
corrected in both phantom and human brain images. In the fMRI study, the visual
activation volumes and their BOLD responses were comparable to those from
conventional 3D echo-planar images. Conclusion: The improved imaging efficiency
and dynamic distortion correction capability afforded by 3D esEPI-BUDA are
expected to benefit many EPI applications.Comment: 8 figures, peer-reviewed journal pape
Parcellation of Human Amygdala Subfields Using Orientation Distribution Function and Spectral K-means Clustering
Amygdala plays an important role in fear and emotional learning, which are critical for human survival. Despite the functional relevance and unique circuitry of each human amygdaloid subnuclei, there has yet to be an efficient imaging method for identifying these regions in vivo. A data-driven approach without prior knowledge provides advantages of efficient and objective assessments. The present study uses high angular and high spatial resolution diffusion magnetic resonance imaging to generate orientation distribution function, which bears distinctive microstructural features. The features were extracted using spherical harmonic decomposition to assess microstructural similarity within amygdala subfields are identified via similarity matrices using spectral k-mean clustering. The approach was tested on 32 healthy volunteers and three distinct amygdala subfields were identified including medial, posterior-superior lateral, and anterior-inferior lateral
Hybrid-space reconstruction with add-on distortion correction for simultaneous multi-slab diffusion MRI
Purpose: This study aims to propose a model-based reconstruction algorithm
for simultaneous multi-slab diffusion MRI acquired with blipped-CAIPI gradients
(blipped-SMSlab), which can also incorporate distortion correction.
Methods: We formulate blipped-SMSlab in a 4D k-space with kz gradients for
the intra-slab slice encoding and km (blipped-CAIPI) gradients for the
inter-slab encoding. Because kz and km gradients share the same physical axis,
the blipped-CAIPI gradients introduce phase interference in the z-km domain
while motion induces phase variations in the kz-m domain. Thus, our previous
k-space-based reconstruction would need multiple steps to transform data back
and forth between k-space and image space for phase correction. Here we propose
a model-based hybrid-space reconstruction algorithm to correct the phase errors
simultaneously. Moreover, the proposed algorithm is combined with distortion
correction, and jointly reconstructs data acquired with the blip-up/down
acquisition to reduce the g-factor penalty.
Results: The blipped-CAIPI-induced phase interference is corrected by the
hybrid-space reconstruction. Blipped-CAIPI can reduce the g-factor penalty
compared to the non-blipped acquisition in the basic reconstruction.
Additionally, the joint reconstruction simultaneously corrects the image
distortions and improves the 1/g-factors by around 50%. Furthermore, through
the joint reconstruction, SMSlab acquisitions without the blipped-CAIPI
gradients also show comparable correction performance with blipped-SMSlab.
Conclusion: The proposed model-based hybrid-space reconstruction can
reconstruct blipped-SMSlab diffusion MRI successfully. Its extension to a joint
reconstruction of the blip-up/down acquisition can correct EPI distortions and
further reduce the g-factor penalty compared with the separate reconstruction.Comment: 10 figures+tables, 8 supplementary figure
Texture analysis of multimodal magnetic resonance images in support of diagnostic classification of childhood brain tumours
Primary brain tumours are recognised as the most common form of solid tumours in children, with pilocytic astrocytoma, medulloblastoma and ependymoma being found most frequently. Despite their high mortality rate, early detection can be facilitated through the use of Magnetic Resonance Imaging (MRI), which is the preferred scanning technique for paediatric patients. MRI offers a variety of imaging sequences through structural and functional imaging, as well as providing complementary tissue information. However visual examination of MR images provides limited ability to characterise distinct histological types of brain tumours. In order to improve diagnostic classification, we explore the use of a computer-aided system based on texture analysis (TA) methods. TA has been applied on conventional MRI but has been less commonly studied on diffusion MRI of brain-related pathology. Furthermore, the combination of textural features derived from both imaging approaches has not yet been widely studied. In this thesis, the aim of the research is to investigate TA based on multi-centre multimodal MRI, in order to provide more comprehensive information and develop an automated processing framework for the classification of childhood brain tumours
Mapping hybrid functional-structural connectivity traits in the human connectome
One of the crucial questions in neuroscience is how a rich functional
repertoire of brain states relates to its underlying structural organization.
How to study the associations between these structural and functional layers is
an open problem that involves novel conceptual ways of tackling this question.
We here propose an extension of the Connectivity Independent Component Analysis
(connICA) framework, to identify joint structural-functional connectivity
traits. Here, we extend connICA to integrate structural and functional
connectomes by merging them into common hybrid connectivity patterns that
represent the connectivity fingerprint of a subject. We test this extended
approach on the 100 unrelated subjects from the Human Connectome Project. The
method is able to extract main independent structural-functional connectivity
patterns from the entire cohort that are sensitive to the realization of
different tasks. The hybrid connICA extracted two main task-sensitive hybrid
traits. The first, encompassing the within and between connections of dorsal
attentional and visual areas, as well as fronto-parietal circuits. The second,
mainly encompassing the connectivity between visual, attentional, DMN and
subcortical networks. Overall, these findings confirms the potential ofthe
hybrid connICA for the compression of structural/functional connectomes into
integrated patterns from a set of individual brain networks.Comment: article: 34 pages, 4 figures; supplementary material: 5 pages, 5
figure
The nonhuman primate neuroimaging and neuroanatomy project
Multi-modal neuroimaging projects such as the Human Connectome Project (HCP) and UK Biobank are advancing our understanding of human brain architecture, function, connectivity, and their variability across individuals using high-quality non-invasive data from many subjects. Such efforts depend upon the accuracy of non-invasive brain imaging measures. However, ‘ground truth’ validation of connectivity using invasive tracers is not feasible in humans. Studies using nonhuman primates (NHPs) enable comparisons between invasive and non-invasive measures, including exploration of how “functional connectivity” from fMRI and “tractographic connectivity” from diffusion MRI compare with long-distance connections measured using tract tracing. Our NonHuman Primate Neuroimaging & Neuroanatomy Project (NHP_NNP) is an international effort (6 laboratories in 5 countries) to: (i) acquire and analyze high-quality multi-modal brain imaging data of macaque and marmoset monkeys using protocols and methods adapted from the HCP; (ii) acquire quantitative invasive tract-tracing data for cortical and subcortical projections to cortical areas; and (iii) map the distributions of different brain cell types with immunocytochemical stains to better define brain areal boundaries. We are acquiring high-resolution structural, functional, and diffusion MRI data together with behavioral measures from over 100 individual macaques and marmosets in order to generate non-invasive measures of brain architecture such as myelin and cortical thickness maps, as well as functional and diffusion tractography-based connectomes. We are using classical and next-generation anatomical tracers to generate quantitative connectivity maps based on brain-wide counting of labeled cortical and subcortical neurons, providing ground truth measures of connectivity. Advanced statistical modeling techniques address the consistency of both kinds of data across individuals, allowing comparison of tracer-based and non-invasive MRI-based connectivity measures. We aim to develop improved cortical and subcortical areal atlases by combining histological and imaging methods. Finally, we are collecting genetic and sociality-associated behavioral data in all animals in an effort to understand how genetic variation shapes the connectome and behavior
MRI of the lung (3/3)-current applications and future perspectives
BACKGROUND: MRI of the lung is recommended in a number of clinical indications. Having a non-radiation alternative is particularly attractive in children and young subjects, or pregnant women. METHODS: Provided there is sufficient expertise, magnetic resonance imaging (MRI) may be considered as the preferential modality in specific clinical conditions such as cystic fibrosis and acute pulmonary embolism, since additional functional information on respiratory mechanics and regional lung perfusion is provided. In other cases, such as tumours and pneumonia in children, lung MRI may be considered an alternative or adjunct to other modalities with at least similar diagnostic value. RESULTS: In interstitial lung disease, the clinical utility of MRI remains to be proven, but it could provide additional information that will be beneficial in research, or at some stage in clinical practice. Customised protocols for chest imaging combine fast breath-hold acquisitions from a "buffet" of sequences. Having introduced details of imaging protocols in previous articles, the aim of this manuscript is to discuss the advantages and limitations of lung MRI in current clinical practice. CONCLUSION: New developments and future perspectives such as motion-compensated imaging with self-navigated sequences or fast Fourier decomposition MRI for non-contrast enhanced ventilation- and perfusion-weighted imaging of the lung are discussed. Main Messages • MRI evolves as a third lung imaging modality, combining morphological and functional information. • It may be considered first choice in cystic fibrosis and pulmonary embolism of young and pregnant patients. • In other cases (tumours, pneumonia in children), it is an alternative or adjunct to X-ray and CT. • In interstitial lung disease, it serves for research, but the clinical value remains to be proven. • New users are advised to make themselves familiar with the particular advantages and limitations
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